Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 2211831..2212420 Replicon chromosome
Accession NZ_AP024107
Organism Ralstonia solanacearum strain MAFF 241648

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag JK148_RS10220 Protein ID WP_197342763.1
Coordinates 2211831..2212085 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag JK148_RS10225 Protein ID WP_200763042.1
Coordinates 2212082..2212420 (+) Length 113 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JK148_RS10205 2207070..2207561 - 492 WP_200763039.1 glycoside hydrolase family protein -
JK148_RS10210 2207632..2208288 - 657 WP_200763040.1 hypothetical protein -
JK148_RS10215 2208625..2211780 - 3156 WP_200763041.1 host specificity protein J -
JK148_RS10220 2211831..2212085 + 255 WP_197342763.1 type II toxin-antitoxin system HicA family toxin Toxin
JK148_RS10225 2212082..2212420 + 339 WP_200763042.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
JK148_RS10230 2212490..2213092 - 603 WP_200763043.1 tail assembly protein -
JK148_RS10235 2213096..2213806 - 711 WP_087451244.1 C40 family peptidase -
JK148_RS10240 2213808..2214509 - 702 WP_071623768.1 phage minor tail protein L -
JK148_RS10245 2214506..2215102 - 597 WP_200763044.1 tail fiber assembly protein -
JK148_RS10250 2215108..2215785 - 678 WP_200763046.1 phage tail protein -
JK148_RS10255 2215782..2216120 - 339 WP_200763048.1 phage tail protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-75)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9488.05 Da        Isoelectric Point: 10.3121

>T37856 WP_197342763.1 NZ_AP024107:2211831-2212085 [Ralstonia solanacearum]
MKAKHQKTLELLFSRPTPAGIKWSDAVALMRELGAELEEREGSRVAVFLFGQVKVMHRPHPSPDMDKGAVASMRKWFEEN
GVKP

Download         Length: 255 bp

>T37856 NZ_AP024107:2211831-2212085 [Ralstonia solanacearum]
ATGAAAGCCAAACACCAGAAGACGCTGGAGCTGCTCTTTTCCCGCCCTACGCCAGCGGGCATTAAGTGGTCTGATGCCGT
CGCGCTCATGCGAGAACTGGGCGCGGAATTGGAGGAGCGCGAGGGTTCTCGCGTGGCCGTCTTCCTGTTTGGTCAAGTTA
AAGTGATGCATCGACCGCACCCATCGCCTGATATGGACAAGGGCGCTGTGGCCTCGATGCGTAAGTGGTTCGAGGAAAAC
GGAGTCAAGCCATGA

Antitoxin


Download         Length: 113 a.a.        Molecular weight: 11998.61 Da        Isoelectric Point: 5.1375

>AT37856 WP_200763042.1 NZ_AP024107:2212082-2212420 [Ralstonia solanacearum]
MINVMNISGHKAVIAYDPDIEMFRGEFVGLNGGADFYAADVTGLHREGELSLRVFLEECARRGVEPQKHFSGKFVLRVEG
KVHEAAAIAAAAQGVSLNQWAAGVLEQAAEAA

Download         Length: 339 bp

>AT37856 NZ_AP024107:2212082-2212420 [Ralstonia solanacearum]
ATGATCAACGTCATGAACATCAGCGGCCACAAGGCCGTCATCGCCTACGACCCGGATATCGAAATGTTCCGTGGCGAGTT
TGTTGGCCTGAACGGTGGCGCCGATTTCTACGCCGCCGATGTGACCGGCCTGCACCGCGAAGGTGAGTTGTCGCTGCGCG
TGTTTCTGGAAGAGTGCGCACGGCGTGGCGTTGAGCCGCAAAAGCACTTTTCCGGCAAGTTCGTGCTGCGCGTGGAGGGC
AAGGTGCACGAGGCCGCCGCCATCGCCGCTGCCGCGCAAGGCGTGAGCCTTAACCAGTGGGCAGCCGGCGTGCTGGAGCA
AGCCGCCGAGGCGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References