Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 2125519..2126108 Replicon chromosome
Accession NZ_AP024101
Organism Ralstonia solanacearum strain MAFF 211491

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag JK147_RS09700 Protein ID WP_197342763.1
Coordinates 2125519..2125773 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag JK147_RS09705 Protein ID WP_200763042.1
Coordinates 2125770..2126108 (+) Length 113 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JK147_RS09685 2120758..2121249 - 492 WP_200763039.1 glycoside hydrolase family protein -
JK147_RS09690 2121320..2121976 - 657 WP_200763040.1 hypothetical protein -
JK147_RS09695 2122313..2125468 - 3156 WP_200763041.1 host specificity protein J -
JK147_RS09700 2125519..2125773 + 255 WP_197342763.1 type II toxin-antitoxin system HicA family toxin Toxin
JK147_RS09705 2125770..2126108 + 339 WP_200763042.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
JK147_RS09710 2126178..2126780 - 603 WP_200763043.1 tail assembly protein -
JK147_RS09715 2126784..2127494 - 711 WP_087451244.1 C40 family peptidase -
JK147_RS09720 2127496..2128197 - 702 WP_071623768.1 phage minor tail protein L -
JK147_RS09725 2128194..2128790 - 597 WP_200763044.1 tail fiber assembly protein -
JK147_RS09730 2128796..2129473 - 678 WP_200763046.1 phage tail protein -
JK147_RS09735 2129470..2129808 - 339 WP_200763048.1 phage tail protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2116504..2157244 40740


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-75)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9488.05 Da        Isoelectric Point: 10.3121

>T37843 WP_197342763.1 NZ_AP024101:2125519-2125773 [Ralstonia solanacearum]
MKAKHQKTLELLFSRPTPAGIKWSDAVALMRELGAELEEREGSRVAVFLFGQVKVMHRPHPSPDMDKGAVASMRKWFEEN
GVKP

Download         Length: 255 bp

>T37843 NZ_AP024101:2125519-2125773 [Ralstonia solanacearum]
ATGAAAGCCAAACACCAGAAGACGCTGGAGCTGCTCTTTTCCCGCCCTACGCCAGCGGGCATTAAGTGGTCTGATGCCGT
CGCGCTCATGCGAGAACTGGGCGCGGAATTGGAGGAGCGCGAGGGTTCTCGCGTGGCCGTCTTCCTGTTTGGTCAAGTTA
AAGTGATGCATCGACCGCACCCATCGCCTGATATGGACAAGGGCGCTGTGGCCTCGATGCGTAAGTGGTTCGAGGAAAAC
GGAGTCAAGCCATGA

Antitoxin


Download         Length: 113 a.a.        Molecular weight: 11998.61 Da        Isoelectric Point: 5.1375

>AT37843 WP_200763042.1 NZ_AP024101:2125770-2126108 [Ralstonia solanacearum]
MINVMNISGHKAVIAYDPDIEMFRGEFVGLNGGADFYAADVTGLHREGELSLRVFLEECARRGVEPQKHFSGKFVLRVEG
KVHEAAAIAAAAQGVSLNQWAAGVLEQAAEAA

Download         Length: 339 bp

>AT37843 NZ_AP024101:2125770-2126108 [Ralstonia solanacearum]
ATGATCAACGTCATGAACATCAGCGGCCACAAGGCCGTCATCGCCTACGACCCGGATATCGAAATGTTCCGTGGCGAGTT
TGTTGGCCTGAACGGTGGCGCCGATTTCTACGCCGCCGATGTGACCGGCCTGCACCGCGAAGGTGAGTTGTCGCTGCGCG
TGTTTCTGGAAGAGTGCGCACGGCGTGGCGTTGAGCCGCAAAAGCACTTTTCCGGCAAGTTCGTGCTGCGCGTGGAGGGC
AAGGTGCACGAGGCCGCCGCCATCGCCGCTGCCGCGCAAGGCGTGAGCCTTAACCAGTGGGCAGCCGGCGTGCTGGAGCA
AGCCGCCGAGGCGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References