Detailed information of TA system TA037841

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN-MazE
• Location: 440752..441385
• Replicon: chromosome
• Accession: NZ_AP024101
• Organism: Ralstonia solanacearum strain MAFF 211491

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: JK147_RS01920
• Protein ID: WP_197369056.1
• Coordinates: 440972..441385 (+)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: Q8XUX7
• Locus tag: JK147_RS01915
• Protein ID: WP_011002949.1
• Coordinates: 440752..440985 (+)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JK147_RS01900	436340..437635	-	1296	WP_011002952.1	MFS transporter	-
JK147_RS01905	437643..438893	-	1251	WP_200763332.1	AGE family epimerase/isomerase	-
JK147_RS01910	439088..440695	+	1608	WP_020832850.1	glucan biosynthesis protein	-
JK147_RS01915	440752..440985	+	234	WP_011002949.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
JK147_RS01920	440972..441385	+	414	WP_197369056.1	PIN domain-containing protein	Toxin
JK147_RS01925	441360..441986	-	627	WP_016725173.1	DUF1415 domain-containing protein	-
JK147_RS01930	442177..442548	+	372	WP_165591128.1	hypothetical protein	-
JK147_RS01935	442576..443796	-	1221	WP_011002488.1	ISL3-like element ISRso15 family transposase	-
JK147_RS01940	443930..445882	-	1953	WP_197369209.1	lytic transglycosylase domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	442576..443796	1220

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (7-116)

Antitoxin

• SpoVT-AbrB domain (5-37)

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 15117.51 Da
• Isoelectric Point: 5.5348

>T37841 WP_197369056.1 NZ_AP024101:440972-441385 [Ralstonia solanacearum]
MPATEAFFDSNVVLYLLSADTAKADAAETLLMTGGVVSVQVLNETTHVMRRKLAMPWHAIEMVQEAVRAQCRVEPLTLET
HDLGRRIAERYGLSVYDALIVAAALLAGCNVLYSEDMQHGLVIEQHLRIVNPFPARA

Nucleotide

• Length: 414 bp

>T37841 NZ_AP024101:440972-441385 [Ralstonia solanacearum]
ATGCCCGCGACTGAGGCATTCTTCGACAGCAATGTCGTGCTGTACCTGCTGTCGGCCGACACCGCCAAGGCCGATGCGGC
GGAAACGCTGCTGATGACCGGCGGTGTCGTCAGCGTACAGGTACTGAACGAAACGACGCACGTGATGCGCCGCAAGCTGG
CCATGCCGTGGCACGCGATCGAAATGGTGCAGGAGGCCGTGCGTGCGCAATGCCGGGTCGAGCCGCTGACGCTCGAAACC
CATGATCTCGGACGGCGTATCGCAGAACGCTACGGATTGTCGGTCTATGACGCACTGATCGTCGCGGCGGCATTGCTTGC
CGGCTGCAACGTTCTGTATTCCGAGGATATGCAGCACGGCCTGGTGATCGAGCAGCATCTGCGCATCGTCAATCCTTTTC
CGGCACGGGCATGA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8790.98 Da
• Isoelectric Point: 8.7287

>AT37841 WP_011002949.1 NZ_AP024101:440752-440985 [Ralstonia solanacearum]
MQVSKWGNSLAIRLPAAVVEALQLHEGDDVEVVIAGERSFGVRRKRAARELFDRIHQYRGKLPADFIFERDQANARD

Nucleotide

• Length: 234 bp

>AT37841 NZ_AP024101:440752-440985 [Ralstonia solanacearum]
ATGCAAGTCTCGAAATGGGGCAACAGCCTCGCTATCCGGCTGCCGGCGGCCGTTGTGGAGGCGCTTCAGCTGCACGAAGG
CGACGACGTCGAGGTGGTGATCGCGGGCGAGCGCTCGTTTGGCGTCCGCCGCAAGCGCGCTGCGCGCGAGCTTTTCGACC
GGATCCACCAATATCGCGGCAAGCTGCCCGCCGATTTCATCTTCGAGCGCGACCAGGCCAATGCCCGCGACTGA

Structures

Antitoxin

• AlphaFold DB: A0A223GR76