Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1561106..1562664 Replicon chromosome
Accession NZ_AP024093
Organism Haemophilus haemolyticus strain 2019-19

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag Hhaem_RS07790 Protein ID WP_223893367.1
Coordinates 1561384..1562664 (+) Length 427 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag Hhaem_RS07785 Protein ID WP_223893365.1
Coordinates 1561106..1561384 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Hhaem_RS07760 (Hhaem_14750) 1556481..1557707 + 1227 WP_223893358.1 Ni/Fe-hydrogenase cytochrome b subunit -
Hhaem_RS07765 (Hhaem_14760) 1557707..1559416 + 1710 WP_223893359.1 hydrogenase 2 large subunit -
Hhaem_RS07770 (Hhaem_14770) 1559416..1559889 + 474 WP_223893361.1 HyaD/HybD family hydrogenase maturation endopeptidase -
Hhaem_RS07775 (Hhaem_14780) 1559981..1560490 + 510 WP_223893363.1 hydrogenase-2 assembly chaperone -
Hhaem_RS07780 (Hhaem_14790) 1560519..1560794 + 276 WP_046941998.1 hydrogenase maturation factor HybG -
Hhaem_RS07785 (Hhaem_14800) 1561106..1561384 + 279 WP_223893365.1 helix-turn-helix domain-containing protein Antitoxin
Hhaem_RS07790 (Hhaem_14810) 1561384..1562664 + 1281 WP_223893367.1 type II toxin-antitoxin system HipA family toxin Toxin
Hhaem_RS07795 (Hhaem_14820) 1562746..1565610 - 2865 WP_223893368.1 valine--tRNA ligase -
Hhaem_RS07800 (Hhaem_14830) 1565643..1566284 - 642 WP_106013250.1 hypothetical protein -
Hhaem_RS07805 (Hhaem_14840) 1566297..1566602 - 306 WP_118845389.1 N(4)-acetylcytidine aminohydrolase -
Hhaem_RS07810 (Hhaem_14850) 1566606..1567040 - 435 WP_118845391.1 DNA polymerase III subunit chi -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(6-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-63)


Sequences

Toxin        


Download         Length: 427 a.a.        Molecular weight: 49075.42 Da        Isoelectric Point: 8.9561

>T37830 WP_223893367.1 NZ_AP024093:1561384-1562664 [Haemophilus haemolyticus]
MSNSILNVAMNGLLVGEWRKLTSGATEFQYAEKWLESVRSRPISLSLPLSHKIYRGDSVYNFFDNLLPNNEQIRSRIQQR
FQASTKSPFDLLSAIGQDCIGAIQLYQGENRSVRQIYAEPLNDKELENVLKNYRTFPLGMEKSENFRISLAGAQEKTALL
YYQNQWQRPLHSTATSHIFKLPIGMVAQGQLDLSGSCENEWLCLNIMKAFGLPVPRSQIQYFGEMKVLIVERFDRRWSEN
RSWIIRLPQEDMCQALNIAPARKYENDGGPSVLQIMSLLNGSSNAQADRKQFFKAQIIFWLLCAIDGHGKNFSLFLEQEN
RYRLTPFYDVMSAYPLIKHNGLQKQKVKMAMAWHGENKHYLWDKIQLRHIFNTAKLTGLAKETVEDILHEISTLYPRVSE
INTHGLPNEIVEPILMGLEIQVKKIS

Download         Length: 1281 bp

>T37830 NZ_AP024093:1561384-1562664 [Haemophilus haemolyticus]
ATGAGTAACTCGATTCTAAATGTTGCCATGAATGGCTTGTTAGTCGGTGAATGGCGAAAACTCACCAGTGGCGCAACCGA
ATTTCAGTATGCGGAAAAATGGCTTGAATCTGTCCGCTCGCGCCCTATTTCATTGTCACTGCCCTTGTCACACAAAATTT
ATCGAGGAGATTCCGTTTACAATTTCTTCGATAATCTCCTCCCGAACAACGAACAGATCCGATCACGCATTCAACAACGT
TTCCAAGCCTCAACAAAATCCCCATTTGATTTACTTTCGGCGATTGGACAGGATTGTATCGGCGCAATTCAACTTTATCA
GGGCGAGAACCGCTCTGTACGTCAAATTTATGCAGAACCACTAAATGACAAAGAGCTGGAAAACGTGCTGAAAAACTACC
GCACTTTTCCTCTCGGCATGGAAAAAAGCGAGAATTTCCGAATTTCTTTGGCCGGCGCTCAGGAAAAAACAGCACTACTT
TATTATCAGAATCAATGGCAGCGCCCTTTGCATTCCACCGCGACCAGCCATATTTTTAAACTCCCGATAGGTATGGTGGC
ACAAGGGCAGCTTGATCTTTCCGGCAGCTGTGAAAATGAATGGCTTTGCTTGAATATTATGAAAGCCTTCGGTTTGCCGG
TTCCTCGAAGTCAAATTCAGTATTTCGGTGAAATGAAAGTGTTGATTGTGGAACGTTTTGATCGCCGTTGGTCTGAAAAC
AGGAGTTGGATAATTCGTTTACCACAAGAAGATATGTGCCAAGCACTTAATATCGCTCCTGCACGAAAATATGAAAATGA
CGGAGGGCCGAGTGTTCTGCAAATTATGTCGCTCCTCAACGGTTCATCCAACGCCCAAGCAGATCGCAAGCAGTTTTTCA
AAGCGCAAATTATTTTTTGGCTGCTTTGTGCCATTGACGGCCATGGCAAAAATTTCAGTTTGTTTTTAGAACAAGAGAAT
CGCTATCGTCTAACGCCTTTTTATGACGTGATGTCCGCCTATCCGCTCATCAAACACAACGGACTACAAAAGCAAAAAGT
CAAAATGGCAATGGCGTGGCACGGCGAAAATAAACATTATTTATGGGATAAAATACAACTCCGCCACATTTTCAACACCG
CCAAACTCACAGGCTTGGCAAAGGAAACAGTTGAAGACATTTTGCATGAGATCAGTACGCTATACCCAAGAGTCAGTGAA
ATAAATACCCATGGATTGCCTAATGAAATTGTCGAGCCAATTTTAATGGGACTGGAAATACAGGTGAAAAAGATAAGTTA
A

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10426.80 Da        Isoelectric Point: 5.1473

>AT37830 WP_223893365.1 NZ_AP024093:1561106-1561384 [Haemophilus haemolyticus]
MVITTAKMLSHVIREFRYQGDLSQTDVAKLAGTTQARISAFENEPERTKLETLFKILAGLELELIVQQRKKSSDTAHSIK
EPTATYDDDEAW

Download         Length: 279 bp

>AT37830 NZ_AP024093:1561106-1561384 [Haemophilus haemolyticus]
ATGGTTATCACCACCGCAAAAATGCTTTCTCATGTCATTCGGGAATTTCGCTATCAAGGCGATCTGTCACAAACTGATGT
TGCTAAACTCGCCGGAACGACCCAAGCCAGAATTTCAGCGTTTGAGAATGAGCCGGAGCGTACTAAATTAGAAACACTAT
TTAAAATTCTGGCAGGATTAGAATTAGAGCTTATTGTACAACAACGCAAAAAGTCATCTGATACTGCCCATTCAATCAAA
GAGCCAACAGCAACATACGATGACGATGAGGCGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References