Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 163138..164798 Replicon plasmid pVNTG1
Accession NZ_AP024089
Organism Vibrio nigripulchritudo strain TUMSAT-TG-2018

Toxin (Protein)


Gene name HipA3 Uniprot ID -
Locus tag VNTUMSATTG_RS29140 Protein ID WP_200769003.1
Coordinates 163482..164798 (+) Length 439 a.a.

Antitoxin (Protein)


Gene name HipB3 Uniprot ID -
Locus tag VNTUMSATTG_RS29135 Protein ID WP_200769002.1
Coordinates 163138..163488 (+) Length 117 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VNTUMSATTG_RS29110 159082..159315 + 234 WP_200768999.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
VNTUMSATTG_RS29115 159329..159730 + 402 WP_200769018.1 type II toxin-antitoxin system VapC family toxin -
VNTUMSATTG_RS29120 159744..159953 + 210 WP_200769000.1 hypothetical protein -
VNTUMSATTG_RS29125 160087..161316 - 1230 WP_200769001.1 MFS transporter -
VNTUMSATTG_RS29130 161591..162175 - 585 Protein_147 reverse transcriptase N-terminal domain-containing protein -
VNTUMSATTG_RS29135 163138..163488 + 351 WP_200769002.1 helix-turn-helix domain-containing protein Antitoxin
VNTUMSATTG_RS29140 163482..164798 + 1317 WP_200769003.1 type II toxin-antitoxin system HipA family toxin Toxin
VNTUMSATTG_RS29145 165312..165494 + 183 WP_022614239.1 YegP family protein -
VNTUMSATTG_RS29150 165946..167022 - 1077 WP_200769004.1 hypothetical protein -
VNTUMSATTG_RS29155 167407..168705 + 1299 WP_200769005.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..351712 351712


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(175-412)

Antitoxin

Cro/C1-type helix-turn-helix domain

(19-70)


Sequences

Toxin        


Download         Length: 439 a.a.        Molecular weight: 48889.25 Da        Isoelectric Point: 5.6631

>T37827 WP_200769003.1 NZ_AP024089:163482-164798 [Vibrio nigripulchritudo]
MVDKKYDTAKVRIFGKDVGALAEDTTTGIVSFEYFDEWLKTGFAISQRLPLEAGTFSFPTLNYPTYKGLPAAFADTLPDD
FGNAVINAWLARQGRDPQSFRSLERLLYTGLRGMGALEYTPALSDTIKKQDESITIDSLVTMAQLVLDKRNNLDETIANE
QEAEQALTGILQVGTSAGGARAKAVIAVNSDRTQIRSGQVNAPKGFEHFLLKFDGVVERSSTSEVFGDPKGFGLMEYAYY
LMAKKAGIDISHCELLKENGRAHFMTKRFDRVGNEKVHYQSLCAMDHADFKQPGGYSYEELFTLLRSLRLDRLSALEVFR
RMAFNVIARNHDDHTKNWGFVINSANKWELAPAFDLAYSYKPGSPWVDSHQMSINGKRDNFTKQDLLGVVPPSLQGEAEA
ILSEVHATVATWREIAKDVGVEPSFIDEIESNHRLSLL

Download         Length: 1317 bp

>T37827 NZ_AP024089:163482-164798 [Vibrio nigripulchritudo]
TTGGTAGACAAGAAATACGACACAGCAAAGGTACGTATATTTGGTAAAGATGTCGGCGCTCTGGCTGAAGATACAACGAC
CGGAATCGTTAGCTTTGAATATTTCGATGAGTGGCTAAAAACTGGGTTTGCCATTTCACAAAGGCTCCCTCTTGAGGCTG
GCACGTTTAGTTTCCCCACTCTGAATTATCCAACCTATAAAGGTCTACCTGCAGCCTTCGCAGATACTCTACCCGATGAC
TTTGGTAATGCCGTAATCAATGCCTGGCTTGCACGCCAGGGTCGAGACCCACAATCTTTCCGTTCATTGGAAAGACTGCT
TTATACCGGCTTACGAGGTATGGGAGCTCTTGAGTACACACCCGCATTATCTGACACAATTAAAAAACAAGATGAATCAA
TTACAATCGACTCACTTGTGACAATGGCGCAACTCGTCCTTGACAAAAGAAACAACCTAGATGAAACCATCGCCAATGAG
CAGGAAGCGGAGCAGGCCTTAACTGGCATCCTTCAAGTCGGCACCTCAGCTGGAGGTGCCAGAGCTAAAGCTGTCATCGC
AGTCAACTCAGATCGCACGCAAATACGCTCGGGTCAGGTAAATGCCCCCAAAGGCTTCGAACACTTCCTATTAAAGTTTG
ATGGCGTTGTTGAACGCTCATCCACTAGTGAGGTATTTGGTGACCCTAAGGGCTTCGGTTTAATGGAATATGCCTATTAC
TTAATGGCAAAAAAAGCCGGTATCGATATCTCACATTGCGAACTATTAAAGGAAAACGGACGTGCTCACTTCATGACAAA
ACGGTTTGACCGCGTAGGAAACGAAAAAGTGCATTACCAATCTCTATGCGCTATGGATCACGCAGATTTCAAACAACCAG
GCGGTTACAGTTATGAAGAACTCTTCACCCTATTGCGCTCATTGAGACTTGATCGACTATCAGCACTTGAAGTGTTTAGA
CGCATGGCTTTTAACGTGATTGCCCGCAACCACGATGACCACACAAAAAATTGGGGATTCGTTATCAATAGTGCGAACAA
GTGGGAACTCGCGCCAGCATTCGACTTAGCATATAGCTACAAACCAGGCTCGCCTTGGGTAGACAGCCATCAAATGTCGA
TCAACGGTAAGCGAGACAATTTTACAAAACAAGATTTACTAGGAGTCGTACCTCCGTCACTACAAGGTGAGGCAGAAGCC
ATTTTAAGTGAGGTTCATGCCACAGTGGCAACATGGCGAGAAATAGCAAAAGACGTAGGTGTCGAACCATCATTCATTGA
CGAAATAGAGTCCAACCACAGACTCAGCTTACTATGA

Antitoxin


Download         Length: 117 a.a.        Molecular weight: 13140.28 Da        Isoelectric Point: 10.6732

>AT37827 WP_200769002.1 NZ_AP024089:163138-163488 [Vibrio nigripulchritudo]
MIKSNIYAMSDEALSSELGRRIERRRLNHRSPLTQAQLAKKAGISRSTYQNMIEGKSTLINVIKVLRVLDSLEGIESFLP
EPGISPVQLLKMKGKVRQRVKPTSTPPQPKEEDLDW

Download         Length: 351 bp

>AT37827 NZ_AP024089:163138-163488 [Vibrio nigripulchritudo]
ATGATAAAGTCGAATATATACGCAATGTCAGATGAAGCACTAAGCAGTGAACTTGGTCGTCGAATCGAAAGACGAAGACT
CAATCACCGTTCACCACTTACTCAGGCGCAGCTAGCAAAAAAGGCAGGAATCAGCCGGTCAACATACCAGAATATGATCG
AGGGTAAATCAACCCTAATAAACGTCATCAAGGTACTCAGAGTGTTAGACTCATTGGAAGGTATTGAATCTTTCCTACCA
GAACCTGGAATTAGCCCAGTACAACTTCTCAAAATGAAAGGGAAAGTACGACAAAGGGTAAAACCGACCTCAACGCCACC
ACAGCCTAAAGAGGAGGACTTAGATTGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References