Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 159082..159730 Replicon plasmid pVNTG1
Accession NZ_AP024089
Organism Vibrio nigripulchritudo strain TUMSAT-TG-2018

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag VNTUMSATTG_RS29115 Protein ID WP_200769018.1
Coordinates 159329..159730 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag VNTUMSATTG_RS29110 Protein ID WP_200768999.1
Coordinates 159082..159315 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VNTUMSATTG_RS29085 154530..155078 + 549 WP_200768995.1 hypothetical protein -
VNTUMSATTG_RS29090 155075..155473 + 399 WP_200768996.1 hypothetical protein -
VNTUMSATTG_RS29095 155836..156444 - 609 WP_200768997.1 hypothetical protein -
VNTUMSATTG_RS29100 156708..157388 + 681 WP_200768998.1 hypothetical protein -
VNTUMSATTG_RS29105 157419..158771 + 1353 WP_200769017.1 hypothetical protein -
VNTUMSATTG_RS29110 159082..159315 + 234 WP_200768999.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
VNTUMSATTG_RS29115 159329..159730 + 402 WP_200769018.1 type II toxin-antitoxin system VapC family toxin Toxin
VNTUMSATTG_RS29120 159744..159953 + 210 WP_200769000.1 hypothetical protein -
VNTUMSATTG_RS29125 160087..161316 - 1230 WP_200769001.1 MFS transporter -
VNTUMSATTG_RS29130 161591..162175 - 585 Protein_147 reverse transcriptase N-terminal domain-containing protein -
VNTUMSATTG_RS29135 163138..163488 + 351 WP_200769002.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..351712 351712


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

SpoVT-AbrB domain

(7-54)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14801.22 Da        Isoelectric Point: 7.8047

>T37826 WP_200769018.1 NZ_AP024089:159329-159730 [Vibrio nigripulchritudo]
MLDTCICSFIMREQPITVLQKLQSVVGKQHRIVISAITYQEMQYGLLGKKASPKHAVLVAEFLKRVDEILPWDKAAVDAT
TEVKRDLMARGAPIGNNDTAIAGHAIATGCVLVTNNTREFQRVDSLKLEDWVH

Download         Length: 402 bp

>T37826 NZ_AP024089:159329-159730 [Vibrio nigripulchritudo]
ATGCTAGATACGTGCATTTGCTCGTTCATCATGAGAGAGCAACCTATTACTGTGTTGCAAAAGCTTCAATCTGTGGTCGG
TAAGCAGCACAGGATTGTTATTTCCGCTATCACCTACCAAGAGATGCAATACGGGCTATTAGGCAAAAAGGCTTCTCCTA
AACACGCAGTGCTTGTTGCAGAATTTCTCAAGCGAGTTGATGAGATCTTACCTTGGGATAAAGCGGCAGTTGATGCGACT
ACAGAAGTTAAACGCGACCTAATGGCTAGAGGTGCACCTATTGGTAATAACGATACCGCTATCGCAGGTCATGCTATTGC
AACAGGGTGTGTTCTAGTAACGAACAACACAAGAGAGTTTCAGCGCGTAGACAGCTTAAAACTCGAAGACTGGGTTCATT
AA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8934.89 Da        Isoelectric Point: 4.3217

>AT37826 WP_200768999.1 NZ_AP024089:159082-159315 [Vibrio nigripulchritudo]
MRTVSIFKNGKNQAVRLPKEFEFDGVNELEIHKEGDVITLRPARPDWLSFGEQNKADSDFMADREDVVTDEGRFDFE

Download         Length: 234 bp

>AT37826 NZ_AP024089:159082-159315 [Vibrio nigripulchritudo]
ATGAGAACGGTATCAATCTTTAAAAATGGGAAAAACCAAGCGGTTCGTCTGCCGAAAGAGTTTGAGTTCGACGGCGTGAA
CGAGCTGGAAATTCACAAAGAAGGAGACGTCATTACTTTACGACCAGCTAGACCAGACTGGTTGTCGTTTGGTGAGCAGA
ACAAGGCTGACAGCGATTTCATGGCTGATCGTGAAGATGTAGTGACAGATGAAGGGCGATTTGACTTTGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References