Detailed information of TA system TA037824

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 2143295..2143854
• Replicon: chromosome
• Accession: NZ_AP024088
• Organism: Vibrio nigripulchritudo strain TUMSAT-TG-2018

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: VNTUMSATTG_RS28315
• Protein ID: WP_200768106.1
• Coordinates: 2143576..2143854 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: U4DQE1
• Locus tag: VNTUMSATTG_RS28310
• Protein ID: WP_004404015.1
• Coordinates: 2143295..2143579 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
VNTUMSATTG_RS28290	2138900..2139934	+	1035	WP_200768102.1	iron ABC transporter permease	-
VNTUMSATTG_RS28295	2139931..2140908	+	978	WP_200768103.1	iron chelate uptake ABC transporter family permease subunit	-
VNTUMSATTG_RS28300	2140913..2141710	+	798	WP_200768104.1	ATP-binding cassette domain-containing protein	-
VNTUMSATTG_RS28305	2141957..2142790	+	834	WP_200768105.1	inositol monophosphatase	-
VNTUMSATTG_RS28310	2143295..2143579	+	285	WP_004404015.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
VNTUMSATTG_RS28315	2143576..2143854	+	279	WP_200768106.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
VNTUMSATTG_RS28320	2143904..2144188	-	285	Protein_1922	type II toxin-antitoxin system Phd/YefM family antitoxin	-
VNTUMSATTG_RS28325	2144269..2144913	-	645	WP_200768107.1	DUF998 domain-containing protein	-
VNTUMSATTG_RS28330	2145064..2145819	-	756	WP_200768108.1	uroporphyrinogen-III C-methyltransferase	-
VNTUMSATTG_RS28335	2145872..2146681	-	810	WP_200768109.1	formate/nitrite transporter family protein	-
VNTUMSATTG_RS28340	2146793..2147125	-	333	WP_200768110.1	nitrite reductase small subunit NirD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-72)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10823.51 Da
• Isoelectric Point: 4.4290

>T37824 WP_200768106.1 NZ_AP024088:2143576-2143854 [Vibrio nigripulchritudo]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDSLIEAKVENLLEQPLMGVQRNGIRGRLLIIPEVSIIVPYWVEGDIIRVL
RVLHQKQKFPTD

Nucleotide

• Length: 279 bp

>T37824 NZ_AP024088:2143576-2143854 [Vibrio nigripulchritudo]
ATGATTTTATGGGAAGAAGAGTCACTTAATGATCGTGAAAAGATCTTTGAGTTTCTCTATGACTTCAATCCTGATGCAGC
AGAGAAAACCGACAGCCTCATTGAAGCAAAAGTAGAAAACTTGCTTGAGCAACCTCTTATGGGCGTGCAAAGAAACGGAA
TCCGTGGACGTTTACTCATTATTCCTGAGGTATCAATAATCGTACCGTACTGGGTTGAAGGCGATATTATCCGCGTTTTG
CGTGTGCTCCACCAAAAACAAAAATTCCCTACGGATTGA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 11022.34 Da
• Isoelectric Point: 8.0517

>AT37824 WP_004404015.1 NZ_AP024088:2143295-2143579 [Vibrio nigripulchritudo]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKLDSGKSVFVEHESAKSR
MEERKARIRNRGKQ

Nucleotide

• Length: 285 bp

>AT37824 NZ_AP024088:2143295-2143579 [Vibrio nigripulchritudo]
ATGGACACTAGAATTCAGTTTCGTGTTGATGAGGAAACAAAACGCTTAGCTCAGCAAATGGCTGAAAGCCAGGGTCGTAC
ATTGAGTGATGCTTGCCGAGAACTTACTGAACAACTCGCTGAACAACAAAGAAAAACACTGTCTCACGATGCATGGCTAA
CTGAACAAGTAAACCTAGCATTTGAGAAGCTTGACTCAGGAAAATCGGTTTTCGTTGAACATGAATCGGCTAAATCTCGA
ATGGAAGAACGCAAAGCCAGAATCCGTAACCGAGGTAAGCAATGA

Structures

Antitoxin

• AlphaFold DB: U4DQE1