Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4238458..4239112 Replicon chromosome
Accession NZ_AP023452
Organism Citrobacter koseri strain MPUCK001

Toxin (Protein)


Gene name cptA Uniprot ID A0A078LNB4
Locus tag MPUCK001_RS19980 Protein ID WP_024130921.1
Coordinates 4238458..4238865 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A078LG12
Locus tag MPUCK001_RS19985 Protein ID WP_024130922.1
Coordinates 4238846..4239112 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MPUCK001_RS19960 4234363..4236096 - 1734 WP_049008966.1 single-stranded-DNA-specific exonuclease RecJ -
MPUCK001_RS19965 4236102..4236812 - 711 WP_104868222.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
MPUCK001_RS19970 4236836..4237732 - 897 WP_187305211.1 site-specific tyrosine recombinase XerD -
MPUCK001_RS19975 4237836..4238360 + 525 WP_012134999.1 flavodoxin FldB -
MPUCK001_RS19980 4238458..4238865 - 408 WP_024130921.1 protein YgfX Toxin
MPUCK001_RS19985 4238846..4239112 - 267 WP_024130922.1 FAD assembly factor SdhE Antitoxin
MPUCK001_RS19990 4239369..4240349 + 981 WP_104868221.1 tRNA-modifying protein YgfZ -
MPUCK001_RS19995 4240504..4241163 - 660 WP_012135004.1 hemolysin III family protein -
MPUCK001_RS20000 4241325..4241636 - 312 WP_047461422.1 N(4)-acetylcytidine aminohydrolase -
MPUCK001_RS20005 4241689..4242417 + 729 WP_012135006.1 MurR/RpiR family transcriptional regulator -
MPUCK001_RS20010 4242538..4243971 + 1434 WP_012135007.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15888.77 Da        Isoelectric Point: 11.2845

>T37798 WP_024130921.1 NZ_AP023452:c4238865-4238458 [Citrobacter koseri]
VVLWQSDLRVSWRAQWLSLLIHGLVAALVLLMPWPLSYTPLWLILLSLVVFDCVRSQRRINTRQGEIKLLMDGRLRWQGQ
DWTIQGPPWMLKTGMMLRLRADSGKRQHLWLAADSMDDAEWRDLRRLMLQQATQG

Download         Length: 408 bp

>T37798 NZ_AP023452:c4238865-4238458 [Citrobacter koseri]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCCTGGCGCGCACAATGGCTCTCTTTGCTCATTCATGGGCTTGTCGCCGC
ATTGGTTTTATTGATGCCCTGGCCATTGAGCTACACGCCGCTCTGGCTGATATTGCTTTCGCTGGTGGTGTTCGACTGTG
TGCGCAGTCAGCGGCGGATTAATACCCGGCAGGGCGAAATTAAACTGCTGATGGATGGGCGTTTACGTTGGCAAGGGCAA
GACTGGACGATTCAGGGCCCGCCCTGGATGCTTAAAACCGGCATGATGCTGCGTTTGCGCGCCGACAGCGGGAAGCGTCA
GCACTTGTGGCTGGCGGCGGACAGCATGGATGACGCCGAGTGGCGGGATTTACGGCGGTTAATGTTGCAACAGGCGACGC
AGGGGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10476.00 Da        Isoelectric Point: 4.8836

>AT37798 WP_024130922.1 NZ_AP023452:c4239112-4238846 [Citrobacter koseri]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDNLSDEEKCIFVRLLECDDPDLFNWLMNHGKPGDAELEQMVKLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT37798 NZ_AP023452:c4239112-4238846 [Citrobacter koseri]
ATGGATATTAATAACAAAGCACGTATTCATTGGGCATGCCGTCGCGGTATGCGTGAGCTCGACATTTCTATCATGCCGTT
TTTCGAACATGAGTACGATAACTTAAGCGATGAAGAAAAATGCATCTTTGTTCGTTTGCTGGAATGCGACGATCCTGATT
TATTTAACTGGTTGATGAACCACGGTAAACCGGGGGATGCAGAACTGGAACAAATGGTGAAACTCATCCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A078LNB4

Antitoxin

Source ID Structure
AlphaFold DB A0A078LG12

References