Detailed information of TA system TA037797

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yfjZ-ypjF/CbtA-CbeA
• Location: 4186619..4187280
• Replicon: chromosome
• Accession: NZ_AP023452
• Organism: Citrobacter koseri strain MPUCK001

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: -
• Locus tag: MPUCK001_RS19685
• Protein ID: WP_016239682.1
• Coordinates: 4186619..4186942 (-)
• Length: 108 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: MPUCK001_RS19690
• Protein ID: WP_190286833.1
• Coordinates: 4186963..4187280 (-)
• Length: 106 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MPUCK001_RS19670	4183469..4184188	+	720	WP_024130919.1	(Fe-S)-binding protein	-
MPUCK001_RS19675	4184199..4185626	+	1428	WP_101744090.1	iron-sulfur cluster-binding protein	-
MPUCK001_RS19680	4185619..4186314	+	696	WP_049011223.1	lactate utilization protein C	-
MPUCK001_RS19685	4186619..4186942	-	324	WP_016239682.1	TA system toxin CbtA family protein	Toxin
MPUCK001_RS19690	4186963..4187280	-	318	WP_190286833.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
MPUCK001_RS19695	4187298..4187519	-	222	WP_016239684.1	DUF987 domain-containing protein	-
MPUCK001_RS19700	4187528..4188004	-	477	WP_190286834.1	RadC family protein	-
MPUCK001_RS19705	4188020..4188478	-	459	WP_190286835.1	antirestriction protein	-
MPUCK001_RS19710	4188575..4188814	-	240	WP_151419914.1	DUF905 domain-containing protein	-
MPUCK001_RS19715	4188892..4189365	-	474	WP_190286836.1	hypothetical protein	-
MPUCK001_RS19720	4189387..4190226	-	840	WP_190286837.1	hypothetical protein	-
MPUCK001_RS19725	4190265..4190966	-	702	WP_050134901.1	WYL domain-containing protein	-
MPUCK001_RS19730	4191183..4192004	-	822	WP_182320417.1	DUF945 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-107)

Antitoxin

• Antitoxin CbeA (5-104)

Sequences

Toxin

Protein

• Length: 108 a.a.
• Molecular weight: 12359.39 Da
• Isoelectric Point: 6.4514

>T37797 WP_016239682.1 NZ_AP023452:c4186942-4186619 [Citrobacter koseri]
MKILPATISQAAKPCLSPVTIWQMLLSRLLEQHYGLTLNDTPFCDETVIQEHIDAGITLANAINFLVEKYELVRIDRRGF
SWQEQTPYLTIIDIMRARRDLGLMNRN

Nucleotide

• Length: 324 bp

>T37797 NZ_AP023452:c4186942-4186619 [Citrobacter koseri]
ATGAAAATTCTACCTGCTACAATTTCGCAGGCGGCGAAGCCATGCCTGTCGCCCGTGACTATCTGGCAAATGCTACTTAG
TCGTCTGCTGGAACAGCATTATGGCCTGACACTAAACGATACACCTTTCTGTGATGAAACCGTCATACAGGAACATATCG
ATGCCGGTATCACTCTCGCTAATGCCATTAACTTTCTAGTGGAAAAGTACGAACTGGTTCGTATCGATCGCAGAGGGTTT
AGCTGGCAAGAACAAACGCCATATCTCACGATTATTGATATCATGAGGGCCCGTCGCGATCTGGGTTTAATGAATCGTAA
TTAG

Antitoxin

Protein

• Length: 106 a.a.
• Molecular weight: 11780.36 Da
• Isoelectric Point: 7.2888

>AT37797 WP_190286833.1 NZ_AP023452:c4187280-4186963 [Citrobacter koseri]
MSNTIWGLQRDITPRLGARLVQEGNRLHYLADRASPTGKFSDAESLKLDVAFPHFISKMESMLTTGEMNPRHAHCVTLYY
NGFTCEADTLGSCGYVYVAVYSTQR

Nucleotide

• Length: 318 bp

>AT37797 NZ_AP023452:c4187280-4186963 [Citrobacter koseri]
ATGAGCAACACCATATGGGGCCTGCAGCGAGATATCACGCCGCGCCTGGGAGCACGTCTGGTGCAGGAGGGCAACCGGCT
GCACTACCTGGCTGACCGGGCCAGTCCCACCGGTAAGTTCAGTGATGCCGAATCTCTTAAGCTGGATGTGGCATTTCCGC
ATTTTATCAGCAAGATGGAATCCATGCTGACCACTGGTGAAATGAATCCTCGCCACGCCCACTGCGTCACCCTGTACTAC
AACGGTTTTACTTGCGAAGCCGATACCCTTGGCAGTTGCGGCTATGTATACGTCGCTGTTTATTCCACTCAACGCTAA