37788

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2497725..2498364 Replicon chromosome
Accession NZ_AP023452
Organism Citrobacter koseri strain MPUCK001

Toxin (Protein)


Gene name hicA Uniprot ID A0A381H3Z1
Locus tag MPUCK001_RS11690 Protein ID WP_071818852.1
Coordinates 2498188..2498364 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag MPUCK001_RS11685 Protein ID WP_146209171.1
Coordinates 2497725..2498141 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MPUCK001_RS11665 2493961..2494134 - 174 WP_047464087.1 GhoT/OrtT family toxin -
MPUCK001_RS11670 2494326..2494421 + 96 WP_071818853.1 stress response membrane protein YncL -
MPUCK001_RS11675 2494520..2495944 - 1425 WP_104868644.1 aminobutyraldehyde dehydrogenase -
MPUCK001_RS11680 2496265..2497674 - 1410 WP_104868643.1 PLP-dependent aminotransferase family protein -
MPUCK001_RS11685 2497725..2498141 - 417 WP_146209171.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
MPUCK001_RS11690 2498188..2498364 - 177 WP_071818852.1 type II toxin-antitoxin system HicA family toxin Toxin
MPUCK001_RS11695 2498586..2500547 - 1962 WP_104869133.1 U32 family peptidase -
MPUCK001_RS11700 2500626..2501162 - 537 WP_104868641.1 XRE family transcriptional regulator -
MPUCK001_RS11705 2501255..2502421 + 1167 WP_104868640.1 benzoate/H(+) symporter BenE family transporter -
MPUCK001_RS11710 2502398..2503273 - 876 WP_012132344.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(82-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6810.81 Da        Isoelectric Point: 10.8122

>T37788 WP_071818852.1 NZ_AP023452:c2498364-2498188 [Citrobacter koseri]
VKQSEFRRWLESQGVDVTNGTNHLKLRYHDKRSVMPRHPGDEIKDTLRKAILKQLGLN

Download         Length: 177 bp

>T37788 NZ_AP023452:c2498364-2498188 [Citrobacter koseri]
GTGAAGCAGAGCGAGTTCAGACGCTGGCTTGAATCTCAGGGAGTCGATGTAACAAATGGAACGAATCATTTGAAGTTGAG
ATATCACGACAAACGAAGCGTCATGCCCAGACATCCTGGTGATGAAATTAAAGACACCCTGCGTAAAGCAATACTAAAGC
AGCTTGGTTTGAATTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15312.59 Da        Isoelectric Point: 4.5129

>AT37788 WP_146209171.1 NZ_AP023452:c2498141-2497725 [Citrobacter koseri]
MRYPVNLIPAEEGGYVVSFPDIPEALTQGDTRHESLEAAQGALVTAFEFYFEDNQPIPLPSMVDAADDYVEIPLSIASKV
LLLNAFLESKITQQELARRIGRPKQEITRLFDLKHATKIDAVQIAARALGKELSLTML

Download         Length: 417 bp

>AT37788 NZ_AP023452:c2498141-2497725 [Citrobacter koseri]
ATGCGTTATCCCGTCAATCTCATTCCCGCAGAAGAAGGGGGTTATGTTGTGTCGTTCCCGGACATTCCAGAGGCGTTAAC
ACAAGGTGACACCCGCCATGAGTCTCTCGAAGCCGCGCAGGGCGCATTAGTCACCGCCTTTGAATTTTATTTTGAAGATA
ACCAGCCAATTCCTTTACCTTCAATGGTTGATGCAGCTGATGATTATGTGGAGATTCCTCTAAGCATTGCGTCTAAAGTC
CTTTTGTTGAATGCGTTCCTTGAATCAAAAATCACGCAGCAGGAGCTGGCGAGGCGCATTGGCAGACCCAAGCAGGAAAT
TACCCGACTATTCGACTTAAAACACGCAACGAAAATCGATGCTGTGCAGATTGCGGCCAGAGCATTGGGCAAAGAGTTAT
CGCTGACTATGCTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A381H3Z1

Antitoxin

Source ID Structure

References