Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Hha-TomB/- |
Location | 1436114..1436734 | Replicon | chromosome |
Accession | NZ_AP023452 | ||
Organism | Citrobacter koseri strain MPUCK001 |
Toxin (Protein)
Gene name | Hha | Uniprot ID | R8WYV2 |
Locus tag | MPUCK001_RS06625 | Protein ID | WP_002892050.1 |
Coordinates | 1436114..1436332 (-) | Length | 73 a.a. |
Antitoxin (Protein)
Gene name | TomB | Uniprot ID | A8AJY4 |
Locus tag | MPUCK001_RS06630 | Protein ID | WP_012133514.1 |
Coordinates | 1436360..1436734 (-) | Length | 125 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
MPUCK001_RS06590 | 1431452..1432066 | + | 615 | WP_104868983.1 | hypothetical protein | - |
MPUCK001_RS06595 | 1432146..1432499 | + | 354 | WP_012133521.1 | DUF1428 family protein | - |
MPUCK001_RS06600 | 1432539..1434089 | - | 1551 | WP_190286947.1 | EAL domain-containing protein | - |
MPUCK001_RS06605 | 1434315..1434575 | + | 261 | WP_012133519.1 | type B 50S ribosomal protein L31 | - |
MPUCK001_RS06610 | 1434577..1434717 | + | 141 | WP_003859006.1 | type B 50S ribosomal protein L36 | - |
MPUCK001_RS06615 | 1434795..1435265 | - | 471 | WP_024130587.1 | membrane protein | - |
MPUCK001_RS06620 | 1435379..1435930 | - | 552 | WP_049009805.1 | maltose O-acetyltransferase | - |
MPUCK001_RS06625 | 1436114..1436332 | - | 219 | WP_002892050.1 | hemolysin expression modulator Hha | Toxin |
MPUCK001_RS06630 | 1436360..1436734 | - | 375 | WP_012133514.1 | Hha toxicity modulator TomB | Antitoxin |
MPUCK001_RS06635 | 1437148..1438164 | + | 1017 | WP_190286622.1 | IS5-like element IS5 family transposase | - |
MPUCK001_RS06640 | 1438435..1441581 | - | 3147 | WP_012133513.1 | efflux RND transporter permease AcrB | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | flank | IS/Tn | - | - | 1437184..1438164 | 980 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 73 a.a. Molecular weight: 8628.00 Da Isoelectric Point: 8.9008
>T37785 WP_002892050.1 NZ_AP023452:c1436332-1436114 [Citrobacter koseri]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR
Download Length: 219 bp
>T37785 NZ_AP023452:c1436332-1436114 [Citrobacter koseri]
ATGTCCGATAAACCATTAACGAAAACAGATTATTTGATGCGTTTACGACGCTGCCAGACAATAGACACGCTGGAACGTGT
AATAGAGAAAAATAAATATGAATTGTCTGACAATGAATTGGCTGTATTTTACTCAGCAGCAGATCACCGTCTTGCAGAAT
TGACGATGAATAAGCTCTACGACAAGATTCCCACCTCCGTGTGGAAATTCATTCGCTAA
ATGTCCGATAAACCATTAACGAAAACAGATTATTTGATGCGTTTACGACGCTGCCAGACAATAGACACGCTGGAACGTGT
AATAGAGAAAAATAAATATGAATTGTCTGACAATGAATTGGCTGTATTTTACTCAGCAGCAGATCACCGTCTTGCAGAAT
TGACGATGAATAAGCTCTACGACAAGATTCCCACCTCCGTGTGGAAATTCATTCGCTAA
Antitoxin
Download Length: 125 a.a. Molecular weight: 14437.27 Da Isoelectric Point: 5.1444
>AT37785 WP_012133514.1 NZ_AP023452:c1436734-1436360 [Citrobacter koseri]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNATRANPVSLSC
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNATRANPVSLSC
Download Length: 375 bp
>AT37785 NZ_AP023452:c1436734-1436360 [Citrobacter koseri]
ATGGATGAGTACTCACCCAAAAGACATGATATCGCACAGCTTAAATTTCTCTGTGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCACGGTTGGGTTAATGACCCTACTTCGGCAATCAATCTTCAGCTCAATGAACTGATAGAGC
ATATTGCAACCTTCGCACTTAATTATAAAATTAAGTATAATGAGGACAATAAGCTGATTGCACAGATAGATGAATATCTG
GATGACACCTTTATGTTGTTCAGCAGTTACGGCATTAATGCGCAGGATCTGCAAAAATGGCGAAAATCAGGAAACCGCCT
GTTTCGCTGCTTCGTCAATGCCACAAGGGCGAATCCTGTTAGCTTGTCATGTTAA
ATGGATGAGTACTCACCCAAAAGACATGATATCGCACAGCTTAAATTTCTCTGTGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCACGGTTGGGTTAATGACCCTACTTCGGCAATCAATCTTCAGCTCAATGAACTGATAGAGC
ATATTGCAACCTTCGCACTTAATTATAAAATTAAGTATAATGAGGACAATAAGCTGATTGCACAGATAGATGAATATCTG
GATGACACCTTTATGTTGTTCAGCAGTTACGGCATTAATGCGCAGGATCTGCAAAAATGGCGAAAATCAGGAAACCGCCT
GTTTCGCTGCTTCGTCAATGCCACAAGGGCGAATCCTGTTAGCTTGTCATGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2P8K6F2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A8AJY4 |