Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 185888..186414 Replicon plasmid pN260-2
Accession NZ_AP023449
Organism Enterobacter roggenkampii strain OIPH-N260

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag OIPHN260_RS26015 Protein ID WP_000323025.1
Coordinates 185888..186175 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag OIPHN260_RS26020 Protein ID WP_000534858.1
Coordinates 186175..186414 (-) Length 80 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OIPHN260_RS25975 181199..181492 - 294 WP_045620738.1 hypothetical protein -
OIPHN260_RS25980 182181..182509 - 329 Protein_167 hypothetical protein -
OIPHN260_RS25985 182551..183342 - 792 WP_045620736.1 N-6 DNA methylase -
OIPHN260_RS25990 183383..183583 - 201 WP_013087182.1 hypothetical protein -
OIPHN260_RS25995 183671..184121 - 451 Protein_170 hypothetical protein -
OIPHN260_RS26000 184199..184405 - 207 WP_045337189.1 hypothetical protein -
OIPHN260_RS26005 184467..184781 - 315 WP_045337198.1 hypothetical protein -
OIPHN260_RS26010 185658..185816 - 159 WP_008325141.1 type I toxin-antitoxin system Hok family toxin -
OIPHN260_RS26015 185888..186175 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
OIPHN260_RS26020 186175..186414 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
OIPHN260_RS26025 186677..187600 - 924 WP_000167917.1 cation diffusion facilitator family transporter -
OIPHN260_RS26030 187800..188375 - 576 Protein_177 cytochrome b/b6 domain-containing protein -
OIPHN260_RS26035 189018..190360 - 1343 Protein_178 ISNCY family transposase -
OIPHN260_RS26040 190394..190495 - 102 WP_159106190.1 DUF5431 family protein -
- 190481..190605 - 125 NuclAT_0 - -
- 190481..190605 - 125 NuclAT_0 - -
- 190481..190605 - 125 NuclAT_0 - -
- 190481..190605 - 125 NuclAT_0 - -
OIPHN260_RS26045 190665..191039 - 375 WP_045337335.1 hypothetical protein -
OIPHN260_RS26050 191095..191271 - 177 WP_165322137.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid mcr-10 mrkA / mrkB / mrkC / mrkF / mrkJ 1..244996 244996


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T37783 WP_000323025.1 NZ_AP023449:c186175-185888 [Enterobacter roggenkampii]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T37783 NZ_AP023449:c186175-185888 [Enterobacter roggenkampii]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT37783 WP_000534858.1 NZ_AP023449:c186414-186175 [Enterobacter roggenkampii]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT37783 NZ_AP023449:c186414-186175 [Enterobacter roggenkampii]
ATGGGTAGCATTAACCTACGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGCGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGACTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9


Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References