Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 44102..44628 Replicon plasmid pN260-1
Accession NZ_AP023448
Organism Enterobacter roggenkampii strain OIPH-N260

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag OIPHN260_RS23965 Protein ID WP_000323025.1
Coordinates 44341..44628 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag OIPHN260_RS23960 Protein ID WP_000534858.1
Coordinates 44102..44341 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OIPHN260_RS23945 40429..41667 + 1239 WP_000219087.1 IS110 family transposase -
OIPHN260_RS23950 42143..42715 + 573 WP_001515348.1 cytochrome b/b6 domain-containing protein -
OIPHN260_RS23955 42915..43838 + 924 WP_000167917.1 cation diffusion facilitator family transporter -
OIPHN260_RS23960 44102..44341 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
OIPHN260_RS23965 44341..44628 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
OIPHN260_RS23970 44700..44858 + 159 WP_001447866.1 type I toxin-antitoxin system Hok family toxin -
OIPHN260_RS23975 45467..45787 - 321 WP_000332796.1 hypothetical protein -
OIPHN260_RS23980 46069..46272 - 204 WP_001015183.1 hypothetical protein -
OIPHN260_RS23985 46319..46669 - 351 WP_000743059.1 hypothetical protein -
OIPHN260_RS23990 46729..47328 - 600 WP_001031420.1 hypothetical protein -
OIPHN260_RS23995 47427..48371 - 945 WP_000778029.1 DUF5417 domain-containing protein -
OIPHN260_RS24000 48882..49058 + 177 WP_001371930.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid mcr-9 / blaCTX-M-9 / sul1 / aadA2 / dfrA16 / qnrA1 - 1..272108 272108


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T37779 WP_000323025.1 NZ_AP023448:44341-44628 [Enterobacter roggenkampii]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T37779 NZ_AP023448:44341-44628 [Enterobacter roggenkampii]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT37779 WP_000534858.1 NZ_AP023448:44102-44341 [Enterobacter roggenkampii]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT37779 NZ_AP023448:44102-44341 [Enterobacter roggenkampii]
ATGGGTAGCATTAACCTACGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGCGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGACTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References