Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3978797..3979454 Replicon chromosome
Accession NZ_AP023447
Organism Enterobacter roggenkampii strain OIPH-N260

Toxin (Protein)


Gene name cptA Uniprot ID A0A1H8U0Q4
Locus tag OIPHN260_RS19205 Protein ID WP_021242050.1
Coordinates 3978797..3979207 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W7NX65
Locus tag OIPHN260_RS19210 Protein ID WP_006178375.1
Coordinates 3979188..3979454 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OIPHN260_RS19185 3974790..3976523 - 1734 WP_045415651.1 single-stranded-DNA-specific exonuclease RecJ -
OIPHN260_RS19190 3976529..3977242 - 714 WP_008499708.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
OIPHN260_RS19195 3977271..3978167 - 897 WP_008499709.1 site-specific tyrosine recombinase XerD -
OIPHN260_RS19200 3978269..3978790 + 522 WP_008499710.1 flavodoxin FldB -
OIPHN260_RS19205 3978797..3979207 - 411 WP_021242050.1 protein YgfX Toxin
OIPHN260_RS19210 3979188..3979454 - 267 WP_006178375.1 FAD assembly factor SdhE Antitoxin
OIPHN260_RS19215 3979749..3980729 + 981 WP_047745992.1 tRNA-modifying protein YgfZ -
OIPHN260_RS19220 3980814..3981473 - 660 WP_047745991.1 hemolysin III family protein -
OIPHN260_RS19225 3981739..3982470 + 732 WP_021242053.1 MurR/RpiR family transcriptional regulator -
OIPHN260_RS19230 3982695..3983711 - 1017 WP_202324206.1 IS5 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3982695..3983675 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16097.08 Da        Isoelectric Point: 10.9468

>T37778 WP_021242050.1 NZ_AP023447:c3979207-3978797 [Enterobacter roggenkampii]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNCGMMLRLRKVDGGRCQHLWLAADSMDAAEWRDLRRMLLQQTTQG

Download         Length: 411 bp

>T37778 NZ_AP023447:c3979207-3978797 [Enterobacter roggenkampii]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCGCAGTGGATGTCTTTATTGCTCCACGGTCTGGTTGCGGC
CTTTGTGTTACTGATGCCGTGGCCGCTGAGCTATACGCCGCTGTGGCTGCTGTTACTGTCGTTTGTCGTTTTTGACAGCG
TACGCAGCCAGCGTCGCATTAATGCCCGTCAGGGAGAGATCAAGTTACTGATGGATTCCCGCCTGCGCTGGCAGGGTAAA
GAGTGGGATATTCTCGGTATGCCCTGGATGCTCAACTGCGGCATGATGTTACGGCTACGCAAGGTGGACGGCGGGCGTTG
CCAGCATCTTTGGCTGGCGGCTGACAGTATGGATGCTGCCGAGTGGCGAGACCTGCGCCGGATGCTATTGCAACAGACGA
CGCAGGGGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10569.05 Da        Isoelectric Point: 5.1340

>AT37778 WP_006178375.1 NZ_AP023447:c3979454-3979188 [Enterobacter roggenkampii]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT37778 NZ_AP023447:c3979454-3979188 [Enterobacter roggenkampii]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATTTCCATCATGCCTTT
CTTCGAATATGAGTATGACACCTTAAGCGACGACGATAAGCGTCTGTTTGTTCGCCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAACCACGGCAAACCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8U0Q4

Antitoxin

Source ID Structure
AlphaFold DB W7NX65

References