Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1200510..1201130 Replicon chromosome
Accession NZ_AP023447
Organism Enterobacter roggenkampii strain OIPH-N260

Toxin (Protein)


Gene name Hha Uniprot ID A0A1H8SI38
Locus tag OIPHN260_RS05790 Protein ID WP_008499287.1
Coordinates 1200510..1200728 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V3PBI9
Locus tag OIPHN260_RS05795 Protein ID WP_008499288.1
Coordinates 1200756..1201130 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OIPHN260_RS05760 1196523..1196783 + 261 WP_006176933.1 type B 50S ribosomal protein L31 -
OIPHN260_RS05765 1196786..1196926 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
OIPHN260_RS05770 1196923..1197633 - 711 WP_045416683.1 GNAT family N-acetyltransferase -
OIPHN260_RS05775 1197735..1199195 + 1461 WP_039265854.1 PLP-dependent aminotransferase family protein -
OIPHN260_RS05780 1199167..1199634 - 468 WP_008499285.1 membrane protein -
OIPHN260_RS05785 1199752..1200303 - 552 WP_047745410.1 maltose O-acetyltransferase -
OIPHN260_RS05790 1200510..1200728 - 219 WP_008499287.1 hemolysin expression modulator Hha Toxin
OIPHN260_RS05795 1200756..1201130 - 375 WP_008499288.1 Hha toxicity modulator TomB Antitoxin
OIPHN260_RS05800 1201640..1204786 - 3147 WP_008499289.1 multidrug efflux RND transporter permease subunit -
OIPHN260_RS05805 1204809..1206002 - 1194 WP_021241633.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8612.00 Da        Isoelectric Point: 8.9008

>T37767 WP_008499287.1 NZ_AP023447:c1200728-1200510 [Enterobacter roggenkampii]
MSDKPLTKIDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFVR

Download         Length: 219 bp

>T37767 NZ_AP023447:c1200728-1200510 [Enterobacter roggenkampii]
ATGTCTGATAAACCACTCACAAAAATCGATTATTTGATGCGCTTACGACGTTGTCAGTCAATTGACACCCTCGAACGCGT
GATTGAAAAGAATAAATACGAGCTTTCTGATAATGAACTGGCCGTATTTTATTCAGCCGCTGACCATCGTCTTGCTGAGC
TGACCATGAATAAGTTGTATGACAAAATCCCTACTTCTGTATGGAAATTTGTCCGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14481.28 Da        Isoelectric Point: 4.8886

>AT37767 WP_008499288.1 NZ_AP023447:c1201130-1200756 [Enterobacter roggenkampii]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNVSRANPVSLSC

Download         Length: 375 bp

>AT37767 NZ_AP023447:c1201130-1200756 [Enterobacter roggenkampii]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAACCTTGATGAAAGCAACCATGGCTGGGTAAACGACCCAACGTCTGCCATCAATTTACAGTTGAATGAGCTGATAGAGC
ATATCGCAACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGCTCATTGAGCAAATTGATGAATACCTG
GACGACACCTTTATGTTGTTCAGTAGTTACGGCATTAACGCCCAGGATTTGCAAAAATGGCGTAAATCGGGAAACCGGCT
ATTCCGCTGTTTCGTCAACGTGAGCAGAGCTAACCCGGTTAGCCTTTCCTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8SI38

Antitoxin

Source ID Structure
AlphaFold DB V3PBI9

References