Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type VII Classification (family/domain) HepT-MntA/HepT(toxin)
Location 5666703..5667595 Replicon chromosome
Accession NZ_AP023441
Organism Nostoc sp. MS1

Toxin (Protein)


Gene name hepT Uniprot ID -
Locus tag NSMS1_RS24380 Protein ID WP_224087272.1
Coordinates 5667152..5667595 (+) Length 148 a.a.

Antitoxin (Protein)


Gene name mntA Uniprot ID -
Locus tag NSMS1_RS24375 Protein ID WP_224087271.1
Coordinates 5666703..5667155 (+) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NSMS1_RS24355 (NSMS1_47770) 5662296..5664476 + 2181 WP_224087267.1 type I-D CRISPR-associated helicase Cas3' -
NSMS1_RS24360 (NSMS1_47780) 5664985..5665224 + 240 WP_224087268.1 hypothetical protein -
NSMS1_RS24365 (NSMS1_47790) 5665399..5665617 + 219 WP_224087269.1 DUF433 domain-containing protein -
NSMS1_RS24370 (NSMS1_47800) 5665635..5666654 + 1020 WP_224087270.1 PDDEXK nuclease domain-containing protein -
NSMS1_RS24375 (NSMS1_47810) 5666703..5667155 + 453 WP_224087271.1 nucleotidyltransferase domain-containing protein Antitoxin
NSMS1_RS24380 (NSMS1_47820) 5667152..5667595 + 444 WP_224087272.1 DUF86 domain-containing protein Toxin
NSMS1_RS24385 (NSMS1_47830) 5667588..5670917 + 3330 WP_224087273.1 type I-D CRISPR-associated protein Cas10d/Csc3 -
NSMS1_RS24390 (NSMS1_47840) 5670963..5671979 + 1017 WP_224087274.1 type I-D CRISPR-associated protein Cas7/Csc2 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease HepT-like

(17-133)

Antitoxin

Polymerase beta, nucleotidyltransferase

(20-113)


Sequences

Toxin        


Download         Length: 148 a.a.        Molecular weight: 17035.41 Da        Isoelectric Point: 4.8029

>T37761 WP_224087272.1 NZ_AP023441:5667152-5667595 [Nostoc sp. MS1]
MSNIEPEIVLVRLRLITKYYNTLEKFRSTSPDEFLNDFEKQLVVERLLQLMTQAAIDINEHILSRLNPGNSATNFEGFIE
VGKYQVITPELARQIAPSSGLRNRLVHEYDEIDPQEVFKAIRFALQQYPLYVRQVSSYLISLSQEDG

Download         Length: 444 bp

>T37761 NZ_AP023441:5667152-5667595 [Nostoc sp. MS1]
ATGAGCAACATAGAACCAGAAATAGTTTTGGTTAGGCTAAGGTTAATTACCAAATATTACAATACTTTAGAAAAGTTTCG
CTCCACTAGTCCTGATGAATTTCTCAATGATTTTGAAAAACAACTTGTTGTAGAAAGACTGCTGCAATTAATGACTCAAG
CAGCAATAGATATTAATGAACATATATTATCAAGATTAAATCCTGGCAATTCTGCTACAAATTTTGAAGGATTTATTGAA
GTTGGCAAATATCAAGTGATCACACCAGAACTAGCAAGACAAATCGCACCGTCATCGGGATTAAGGAACCGTCTTGTGCA
TGAATATGACGAGATAGATCCGCAAGAAGTTTTTAAAGCTATTCGTTTTGCATTGCAACAATATCCGCTTTACGTGCGCC
AAGTTAGCTCTTATTTAATTTCTTTGAGTCAAGAAGATGGTTAA

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 17691.26 Da        Isoelectric Point: 5.3316

>AT37761 WP_224087271.1 NZ_AP023441:5666703-5667155 [Nostoc sp. MS1]
MQNNTPTIRELQELSLQIPEKIPYLKMLVLFGSRATGNINAKSDWDFAVLYDQEQREAYVKDNSFRLFELPLIIGEVFKV
NSDQIDVVDLDHCSELISHFIARDGIMLFEKDNGEFEKFRLRSLKSESELKHFRKEQHKIIEMELKRWGA

Download         Length: 453 bp

>AT37761 NZ_AP023441:5666703-5667155 [Nostoc sp. MS1]
ATGCAAAACAATACTCCAACAATCAGAGAACTGCAAGAACTTTCTTTACAAATACCTGAAAAAATTCCTTACTTAAAAAT
GTTAGTTTTGTTTGGTTCTAGGGCTACTGGTAACATCAACGCTAAGAGTGACTGGGATTTTGCTGTTCTGTATGATCAAG
AACAACGTGAGGCTTATGTAAAAGATAATAGTTTCCGTTTATTTGAATTACCTCTAATAATTGGCGAAGTATTCAAAGTA
AATTCAGATCAAATTGACGTTGTAGACCTTGATCATTGTTCAGAACTTATATCACATTTTATTGCTCGTGATGGAATTAT
GTTATTTGAAAAAGATAACGGAGAATTTGAAAAGTTTAGATTAAGGTCACTTAAATCTGAATCTGAGTTAAAACATTTCC
GTAAAGAACAACATAAAATTATTGAAATGGAATTGAAAAGGTGGGGTGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References