Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/YoeB-RelB
Location 4524388..4524901 Replicon chromosome
Accession NZ_AP023441
Organism Nostoc sp. MS1

Toxin (Protein)


Gene name relB Uniprot ID -
Locus tag NSMS1_RS19630 Protein ID WP_224086445.1
Coordinates 4524388..4524654 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag NSMS1_RS19635 Protein ID WP_224086446.1
Coordinates 4524647..4524901 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NSMS1_RS19610 (NSMS1_38550) 4519466..4520986 + 1521 WP_224086442.1 F0F1 ATP synthase subunit alpha -
NSMS1_RS19615 (NSMS1_38560) 4521107..4522054 + 948 WP_224095283.1 F0F1 ATP synthase subunit gamma -
NSMS1_RS19620 (NSMS1_38570) 4522242..4523759 + 1518 WP_224086443.1 GNAT family N-acetyltransferase -
NSMS1_RS19625 (NSMS1_38580) 4523749..4524246 + 498 WP_224086444.1 hypothetical protein -
NSMS1_RS19630 (NSMS1_38590) 4524388..4524654 - 267 WP_224086445.1 Txe/YoeB family addiction module toxin Toxin
NSMS1_RS19635 (NSMS1_38600) 4524647..4524901 - 255 WP_224086446.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
NSMS1_RS19640 (NSMS1_38610) 4525039..4525317 + 279 WP_224086447.1 DUF1778 domain-containing protein -
NSMS1_RS19645 (NSMS1_38620) 4525323..4525820 + 498 WP_224086448.1 GNAT family N-acetyltransferase -
NSMS1_RS19655 (NSMS1_38630) 4527249..4527926 + 678 WP_224086449.1 hypothetical protein -
NSMS1_RS19660 (NSMS1_38640) 4528028..4529254 + 1227 WP_224086450.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(7-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10622.09 Da        Isoelectric Point: 6.9766

>T37760 WP_224086445.1 NZ_AP023441:c4524654-4524388 [Nostoc sp. MS1]
MSRKLVWTDEAWSDYLYWQEQDKKTLKRINKLIEATMRLPFEGIGKPEALKENLASFWSRRIDDTNRLVYAVDDQYLTII
ACRYHYSD

Download         Length: 267 bp

>T37760 NZ_AP023441:c4524654-4524388 [Nostoc sp. MS1]
ATGAGTAGAAAGTTAGTATGGACAGATGAGGCTTGGAGCGATTATTTATATTGGCAAGAGCAAGACAAGAAAACATTAAA
ACGAATTAACAAGCTGATTGAGGCGACAATGCGACTACCGTTTGAGGGGATAGGTAAGCCAGAAGCCTTGAAAGAAAACC
TAGCTAGCTTTTGGTCGCGGCGCATTGATGATACTAATCGGTTAGTTTATGCGGTGGATGATCAGTACTTAACGATTATT
GCTTGCCGTTACCACTATTCTGATTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9498.88 Da        Isoelectric Point: 5.1133

>AT37760 WP_224086446.1 NZ_AP023441:c4524901-4524647 [Nostoc sp. MS1]
MKVVSFSEARNNLKAVLDQVVEDADYTIITRRDAEDAVVMSLELFNSLLETVHLLKSPANAAHLERSITQFKQGKVVERK
LLDE

Download         Length: 255 bp

>AT37760 NZ_AP023441:c4524901-4524647 [Nostoc sp. MS1]
ATGAAAGTTGTCTCTTTTAGCGAAGCGAGAAATAACCTCAAGGCTGTTTTAGACCAAGTGGTGGAAGATGCAGACTATAC
CATCATTACTAGACGGGATGCGGAGGATGCTGTTGTGATGTCGCTAGAGTTATTTAATAGTTTGCTGGAGACTGTTCATT
TACTCAAGTCACCCGCTAATGCTGCTCATTTGGAGCGTTCTATTACTCAGTTTAAGCAGGGGAAAGTGGTGGAGCGCAAA
TTGTTAGATGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References