Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2617791..2618340 Replicon chromosome
Accession NZ_AP023441
Organism Nostoc sp. MS1

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag NSMS1_RS11345 Protein ID WP_224093221.1
Coordinates 2618002..2618340 (+) Length 113 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag NSMS1_RS11340 Protein ID WP_224093220.1
Coordinates 2617791..2618015 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NSMS1_RS11320 (NSMS1_22260) 2614140..2615198 - 1059 Protein_2250 IS701 family transposase -
NSMS1_RS11325 2615254..2616365 + 1112 WP_224087799.1 IS630 family transposase -
NSMS1_RS11330 2616389..2616610 - 222 Protein_2252 transposase -
NSMS1_RS11335 2617270..2617271 - 2 WP_263432538.1 IS630 family transposase -
NSMS1_RS11340 (NSMS1_22310) 2617791..2618015 + 225 WP_224093220.1 ribbon-helix-helix domain-containing protein Antitoxin
NSMS1_RS11345 (NSMS1_22320) 2618002..2618340 + 339 WP_224093221.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
NSMS1_RS11350 (NSMS1_22330) 2618539..2619906 + 1368 WP_224093222.1 NAD-dependent succinate-semialdehyde dehydrogenase -
NSMS1_RS11355 (NSMS1_22340) 2620010..2621656 + 1647 WP_224093223.1 acetolactate synthase large subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 12327.42 Da        Isoelectric Point: 8.5046

>T37759 WP_224093221.1 NZ_AP023441:2618002-2618340 [Nostoc sp. MS1]
MKRGDIYYADLSPTLGSEMGKRRPVLVVSNNISNRVATTVTILPLTSNVNRVYPFEVLLNPEVSGLTKPSKVQAQQVRTI
SKERIMGEVVGSLDEEMMVLIDAALMLHLGLT

Download         Length: 339 bp

>T37759 NZ_AP023441:2618002-2618340 [Nostoc sp. MS1]
ATGAAACGTGGTGATATTTACTACGCAGACCTTAGTCCTACCCTTGGTTCAGAAATGGGTAAACGCCGTCCAGTGCTGGT
AGTGAGTAATAACATTAGTAATCGTGTTGCTACGACAGTAACGATTTTACCTCTTACTTCTAACGTTAATCGTGTTTATC
CTTTTGAAGTGCTGCTAAATCCAGAGGTGAGTGGTTTAACAAAACCTTCTAAAGTCCAGGCGCAACAGGTAAGAACAATT
TCTAAGGAACGAATTATGGGCGAAGTAGTGGGTAGTTTAGATGAAGAGATGATGGTACTAATTGATGCTGCCTTGATGTT
GCATTTGGGATTGACTTGA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8463.45 Da        Isoelectric Point: 4.1835

>AT37759 WP_224093220.1 NZ_AP023441:2617791-2618015 [Nostoc sp. MS1]
MKAEKLSISLPPSLVEFIENYKFNKGCKSRSQVIEEALELLRNRELEEAYREASAEVDSDWNVTVADGLADETW

Download         Length: 225 bp

>AT37759 NZ_AP023441:2617791-2618015 [Nostoc sp. MS1]
ATGAAAGCAGAAAAATTATCTATTTCTTTACCACCATCCTTAGTGGAGTTTATCGAAAACTATAAGTTTAATAAAGGATG
TAAATCTCGTTCTCAAGTAATTGAAGAAGCGTTAGAGTTACTGCGAAATCGAGAACTAGAAGAGGCTTATCGAGAAGCCT
CTGCGGAAGTTGACAGTGATTGGAATGTAACAGTAGCAGATGGACTAGCAGATGAAACGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References