Detailed information of TA system TA037758

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 1643908..1644514
• Replicon: chromosome
• Accession: NZ_AP023441
• Organism: Nostoc sp. MS1

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: NSMS1_RS07245
• Protein ID: WP_224092187.1
• Coordinates: 1643908..1644204 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: NSMS1_RS07250
• Protein ID: WP_224092188.1
• Coordinates: 1644194..1644514 (+)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NSMS1_RS07210 (NSMS1_14270)	1639043..1639357	-	315	WP_224092180.1	50S ribosomal protein L23	-
NSMS1_RS07215 (NSMS1_14280)	1639350..1639982	-	633	WP_224092181.1	50S ribosomal protein L4	-
NSMS1_RS07220 (NSMS1_14290)	1640047..1640682	-	636	WP_224092182.1	50S ribosomal protein L3	-
NSMS1_RS35035	1640759..1640881	+	123	WP_263432563.1	hypothetical protein	-
NSMS1_RS07225 (NSMS1_14300)	1641504..1641992	+	489	WP_224092183.1	NAD(P)H-quinone oxidoreductase subunit N	-
NSMS1_RS07230 (NSMS1_14310)	1642124..1642600	-	477	WP_224092184.1	GNAT family N-acetyltransferase	-
NSMS1_RS07235	1642685..1642855	-	171	WP_224092185.1	hypothetical protein	-
NSMS1_RS07240 (NSMS1_14320)	1642886..1643713	-	828	WP_224092186.1	ABC transporter permease	-
NSMS1_RS07245 (NSMS1_14330)	1643908..1644204	+	297	WP_224092187.1	type II toxin-antitoxin system HicA family toxin	Toxin
NSMS1_RS07250 (NSMS1_14340)	1644194..1644514	+	321	WP_224092188.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
NSMS1_RS07255 (NSMS1_14350)	1644757..1645212	-	456	WP_224092189.1	pentapeptide repeat-containing protein	-
NSMS1_RS07260 (NSMS1_14360)	1645524..1646387	-	864	WP_224092190.1	alpha/beta hydrolase	-
NSMS1_RS07265 (NSMS1_14370)	1646509..1647348	+	840	WP_224092191.1	endonuclease/exonuclease/phosphatase family protein	-
NSMS1_RS07270 (NSMS1_14380)	1647358..1648800	+	1443	WP_224092192.1	cardiolipin synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (25-83)

Antitoxin

• Uncharacterised protein family HicB (51-101)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 10941.40 Da
• Isoelectric Point: 6.8814

>T37758 WP_224092187.1 NZ_AP023441:1643908-1644204 [Nostoc sp. MS1]
MVLNSKHQKTLDDVFESPVRANILWSDIESLLIALGAEVSEGRGSRVRIALSSVRAIFHRPHPQKETDKGAVKSMRHFLT
EAGFKEDISTGELNNNEI

Nucleotide

• Length: 297 bp

>T37758 NZ_AP023441:1643908-1644204 [Nostoc sp. MS1]
ATGGTACTAAACAGCAAACATCAAAAAACCCTAGATGACGTTTTTGAAAGTCCGGTTAGAGCCAATATCCTGTGGAGTGA
TATTGAGTCTTTGTTGATTGCGCTTGGTGCGGAAGTGTCAGAAGGAAGGGGGTCAAGAGTGAGGATAGCTCTTAGTAGTG
TCAGAGCAATTTTCCACCGACCACACCCACAAAAAGAAACTGATAAAGGTGCTGTTAAGTCTATGCGGCACTTTTTGACA
GAAGCCGGGTTTAAAGAAGACATAAGCACAGGGGAGCTAAATAACAATGAGATATAA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 12300.00 Da
• Isoelectric Point: 5.0049

>AT37758 WP_224092188.1 NZ_AP023441:1644194-1644514 [Nostoc sp. MS1]
MRYKGYEAVVEFDDEAEIFHGEVINIRDVITFQADNVKELKQAFHDSVDDYLEFCKERGEEPEKPFSGKLMLRINPELHK
TIAVKAKKEGKSLNSWIEKCLCQYAG

Nucleotide

• Length: 321 bp

>AT37758 NZ_AP023441:1644194-1644514 [Nostoc sp. MS1]
ATGAGATATAAAGGATATGAAGCCGTTGTTGAGTTTGATGATGAAGCTGAAATCTTTCATGGCGAAGTGATCAACATTCG
AGATGTGATTACATTTCAGGCTGATAACGTAAAAGAGCTAAAGCAAGCCTTTCACGACTCAGTTGATGATTATTTAGAAT
TTTGCAAAGAACGTGGTGAAGAACCTGAAAAGCCATTTTCAGGTAAGCTAATGCTCAGAATTAACCCGGAGTTACATAAA
ACAATTGCTGTCAAGGCAAAGAAAGAGGGTAAAAGCCTTAACTCTTGGATAGAAAAATGCTTGTGCCAGTATGCTGGTTA
A