Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/VapC-MazE |
Location | 1268200..1268826 | Replicon | chromosome |
Accession | NZ_AP023441 | ||
Organism | Nostoc sp. MS1 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | - |
Locus tag | NSMS1_RS05575 | Protein ID | WP_224091795.1 |
Coordinates | 1268428..1268826 (+) | Length | 133 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | - |
Locus tag | NSMS1_RS05570 | Protein ID | WP_224091794.1 |
Coordinates | 1268200..1268427 (+) | Length | 76 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
NSMS1_RS05540 (NSMS1_10980) | 1264580..1264852 | - | 273 | WP_224091788.1 | hypothetical protein | - |
NSMS1_RS05545 (NSMS1_10990) | 1265097..1265261 | + | 165 | WP_224091789.1 | hypothetical protein | - |
NSMS1_RS05550 (NSMS1_11000) | 1265409..1265747 | - | 339 | WP_224091790.1 | metalloregulator ArsR/SmtB family transcription factor | - |
NSMS1_RS05555 (NSMS1_11010) | 1265824..1266156 | + | 333 | WP_224091791.1 | thioredoxin | - |
NSMS1_RS05560 (NSMS1_11020) | 1266217..1267314 | + | 1098 | WP_224091792.1 | alkene reductase | - |
NSMS1_RS05565 (NSMS1_11030) | 1267395..1268060 | + | 666 | WP_224091793.1 | nitroreductase family protein | - |
NSMS1_RS05570 (NSMS1_11040) | 1268200..1268427 | + | 228 | WP_224091794.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
NSMS1_RS05575 (NSMS1_11050) | 1268428..1268826 | + | 399 | WP_224091795.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
NSMS1_RS05580 (NSMS1_11060) | 1269033..1269350 | - | 318 | WP_224091796.1 | DUF2973 domain-containing protein | - |
NSMS1_RS05585 | 1269595..1269912 | - | 318 | WP_224091797.1 | DUF2605 domain-containing protein | - |
NSMS1_RS05590 (NSMS1_11080) | 1270355..1272202 | + | 1848 | WP_224091798.1 | threonine--tRNA ligase | - |
NSMS1_RS05595 (NSMS1_11090) | 1272633..1273124 | + | 492 | WP_224091799.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 133 a.a. Molecular weight: 14765.25 Da Isoelectric Point: 6.9763
>T37757 WP_224091795.1 NZ_AP023441:1268428-1268826 [Nostoc sp. MS1]
MQYLLDTNICIYLIKQKPQKVLDKFQTLSIFEIGISSITVAELEYGVAKSQQKEKNRTALLQFLLPLEIVEFNQASATIY
GSIRSYLESQGSVIGAMGMLIAAHALSLGVTLVSNNIREFSRIPNLLLENWV
MQYLLDTNICIYLIKQKPQKVLDKFQTLSIFEIGISSITVAELEYGVAKSQQKEKNRTALLQFLLPLEIVEFNQASATIY
GSIRSYLESQGSVIGAMGMLIAAHALSLGVTLVSNNIREFSRIPNLLLENWV
Download Length: 399 bp
>T37757 NZ_AP023441:1268428-1268826 [Nostoc sp. MS1]
ATGCAATACCTGCTTGATACCAATATTTGCATTTACCTCATCAAGCAAAAACCTCAAAAAGTACTGGATAAATTTCAAAC
CTTAAGTATTTTTGAGATAGGTATTTCCTCTATTACTGTTGCTGAACTTGAGTACGGAGTTGCTAAAAGCCAACAAAAAG
AGAAAAACCGTACAGCTTTGCTACAATTTTTGCTACCTCTAGAAATTGTCGAATTTAATCAAGCATCTGCAACGATTTAC
GGCAGCATTAGAAGTTATCTTGAAAGTCAAGGGAGCGTTATTGGTGCAATGGGTATGCTCATCGCCGCTCATGCCTTAAG
TTTAGGAGTAACTCTTGTCAGCAATAATATTAGAGAATTTTCTCGCATTCCTAATTTGTTATTAGAAAATTGGGTTTAA
ATGCAATACCTGCTTGATACCAATATTTGCATTTACCTCATCAAGCAAAAACCTCAAAAAGTACTGGATAAATTTCAAAC
CTTAAGTATTTTTGAGATAGGTATTTCCTCTATTACTGTTGCTGAACTTGAGTACGGAGTTGCTAAAAGCCAACAAAAAG
AGAAAAACCGTACAGCTTTGCTACAATTTTTGCTACCTCTAGAAATTGTCGAATTTAATCAAGCATCTGCAACGATTTAC
GGCAGCATTAGAAGTTATCTTGAAAGTCAAGGGAGCGTTATTGGTGCAATGGGTATGCTCATCGCCGCTCATGCCTTAAG
TTTAGGAGTAACTCTTGTCAGCAATAATATTAGAGAATTTTCTCGCATTCCTAATTTGTTATTAGAAAATTGGGTTTAA
Antitoxin
Download Length: 76 a.a. Molecular weight: 8523.63 Da Isoelectric Point: 4.5026
>AT37757 WP_224091794.1 NZ_AP023441:1268200-1268427 [Nostoc sp. MS1]
MNIAKLSTDGTHQVVILPEDFQLTGTEVYVKKIGNAIVLIAKDNPWESLIESLDKFSDDFMTNRNQPLTETRESR
MNIAKLSTDGTHQVVILPEDFQLTGTEVYVKKIGNAIVLIAKDNPWESLIESLDKFSDDFMTNRNQPLTETRESR
Download Length: 228 bp
>AT37757 NZ_AP023441:1268200-1268427 [Nostoc sp. MS1]
ATGAATATTGCCAAACTCAGCACTGATGGCACTCATCAAGTCGTTATTTTACCTGAAGATTTTCAACTCACAGGCACAGA
AGTTTATGTTAAAAAAATCGGTAATGCAATTGTTCTTATTGCCAAAGATAATCCTTGGGAATCTCTAATTGAGAGTTTAG
ACAAATTTTCCGATGATTTCATGACTAATAGAAATCAGCCATTAACAGAAACTAGAGAGAGTAGGTAA
ATGAATATTGCCAAACTCAGCACTGATGGCACTCATCAAGTCGTTATTTTACCTGAAGATTTTCAACTCACAGGCACAGA
AGTTTATGTTAAAAAAATCGGTAATGCAATTGTTCTTATTGCCAAAGATAATCCTTGGGAATCTCTAATTGAGAGTTTAG
ACAAATTTTCCGATGATTTCATGACTAATAGAAATCAGCCATTAACAGAAACTAGAGAGAGTAGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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