Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-MazE
Location 1268200..1268826 Replicon chromosome
Accession NZ_AP023441
Organism Nostoc sp. MS1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NSMS1_RS05575 Protein ID WP_224091795.1
Coordinates 1268428..1268826 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag NSMS1_RS05570 Protein ID WP_224091794.1
Coordinates 1268200..1268427 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NSMS1_RS05540 (NSMS1_10980) 1264580..1264852 - 273 WP_224091788.1 hypothetical protein -
NSMS1_RS05545 (NSMS1_10990) 1265097..1265261 + 165 WP_224091789.1 hypothetical protein -
NSMS1_RS05550 (NSMS1_11000) 1265409..1265747 - 339 WP_224091790.1 metalloregulator ArsR/SmtB family transcription factor -
NSMS1_RS05555 (NSMS1_11010) 1265824..1266156 + 333 WP_224091791.1 thioredoxin -
NSMS1_RS05560 (NSMS1_11020) 1266217..1267314 + 1098 WP_224091792.1 alkene reductase -
NSMS1_RS05565 (NSMS1_11030) 1267395..1268060 + 666 WP_224091793.1 nitroreductase family protein -
NSMS1_RS05570 (NSMS1_11040) 1268200..1268427 + 228 WP_224091794.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
NSMS1_RS05575 (NSMS1_11050) 1268428..1268826 + 399 WP_224091795.1 type II toxin-antitoxin system VapC family toxin Toxin
NSMS1_RS05580 (NSMS1_11060) 1269033..1269350 - 318 WP_224091796.1 DUF2973 domain-containing protein -
NSMS1_RS05585 1269595..1269912 - 318 WP_224091797.1 DUF2605 domain-containing protein -
NSMS1_RS05590 (NSMS1_11080) 1270355..1272202 + 1848 WP_224091798.1 threonine--tRNA ligase -
NSMS1_RS05595 (NSMS1_11090) 1272633..1273124 + 492 WP_224091799.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14765.25 Da        Isoelectric Point: 6.9763

>T37757 WP_224091795.1 NZ_AP023441:1268428-1268826 [Nostoc sp. MS1]
MQYLLDTNICIYLIKQKPQKVLDKFQTLSIFEIGISSITVAELEYGVAKSQQKEKNRTALLQFLLPLEIVEFNQASATIY
GSIRSYLESQGSVIGAMGMLIAAHALSLGVTLVSNNIREFSRIPNLLLENWV

Download         Length: 399 bp

>T37757 NZ_AP023441:1268428-1268826 [Nostoc sp. MS1]
ATGCAATACCTGCTTGATACCAATATTTGCATTTACCTCATCAAGCAAAAACCTCAAAAAGTACTGGATAAATTTCAAAC
CTTAAGTATTTTTGAGATAGGTATTTCCTCTATTACTGTTGCTGAACTTGAGTACGGAGTTGCTAAAAGCCAACAAAAAG
AGAAAAACCGTACAGCTTTGCTACAATTTTTGCTACCTCTAGAAATTGTCGAATTTAATCAAGCATCTGCAACGATTTAC
GGCAGCATTAGAAGTTATCTTGAAAGTCAAGGGAGCGTTATTGGTGCAATGGGTATGCTCATCGCCGCTCATGCCTTAAG
TTTAGGAGTAACTCTTGTCAGCAATAATATTAGAGAATTTTCTCGCATTCCTAATTTGTTATTAGAAAATTGGGTTTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8523.63 Da        Isoelectric Point: 4.5026

>AT37757 WP_224091794.1 NZ_AP023441:1268200-1268427 [Nostoc sp. MS1]
MNIAKLSTDGTHQVVILPEDFQLTGTEVYVKKIGNAIVLIAKDNPWESLIESLDKFSDDFMTNRNQPLTETRESR

Download         Length: 228 bp

>AT37757 NZ_AP023441:1268200-1268427 [Nostoc sp. MS1]
ATGAATATTGCCAAACTCAGCACTGATGGCACTCATCAAGTCGTTATTTTACCTGAAGATTTTCAACTCACAGGCACAGA
AGTTTATGTTAAAAAAATCGGTAATGCAATTGTTCTTATTGCCAAAGATAATCCTTGGGAATCTCTAATTGAGAGTTTAG
ACAAATTTTCCGATGATTTCATGACTAATAGAAATCAGCCATTAACAGAAACTAGAGAGAGTAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References