Detailed information of TA system TA037756

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Fic(toxin)
• Location: 5916446..5917011
• Replicon: chromosome
• Accession: NZ_AP023440
• Organism: Streptomyces glomeroaurantiacus strain JCM 4677

Toxin (Protein)

• Gene name: doc
• Uniprot ID: -
• Locus tag: IGS71_RS25145
• Protein ID: WP_055513931.1
• Coordinates: 5916643..5917011 (+)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: -
• Locus tag: IGS71_RS25140
• Protein ID: WP_055513929.1
• Coordinates: 5916446..5916643 (+)
• Length: 66 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IGS71_RS25125	5913194..5914417	+	1224	WP_190852250.1	SUKH-4 family immunity protein	-
IGS71_RS25135	5914935..5916413	+	1479	WP_190852252.1	MFS transporter	-
IGS71_RS25140	5916446..5916643	+	198	WP_055513929.1	hypothetical protein	Antitoxin
IGS71_RS25145	5916643..5917011	+	369	WP_055513931.1	type II toxin-antitoxin system death-on-curing family toxin	Toxin
IGS71_RS25150	5917159..5918970	+	1812	WP_190852254.1	DEAD/DEAH box helicase	-
IGS71_RS25155	5919414..5920061	+	648	WP_055513935.1	helix-turn-helix domain-containing protein	-
IGS71_RS25160	5920225..5921043	+	819	WP_190852256.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Fido domain (12-80)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13711.62 Da
• Isoelectric Point: 4.8675

>T37756 WP_055513931.1 NZ_AP023440:5916643-5917011 [Streptomyces glomeroaurantiacus]
MHYLTLPEVLNLAKRLGADEVRDYGLLDSALVRPQSSVFGQDAYPDVWEKAAALMESLARNHALVDGNKRIAWYATWVFL
HMNGHPLDADFDVDEAETFVLDVCQGALDVPKIATRLPRFAR

Nucleotide

• Length: 369 bp

>T37756 NZ_AP023440:5916643-5917011 [Streptomyces glomeroaurantiacus]
ATGCACTACCTCACGCTGCCCGAGGTGCTGAACCTCGCGAAGCGGCTCGGGGCGGACGAGGTCCGCGACTACGGGCTCCT
GGACTCGGCGTTGGTCCGGCCGCAGTCGAGCGTGTTCGGACAGGACGCCTATCCGGACGTCTGGGAGAAGGCGGCGGCCC
TGATGGAGTCGCTCGCCCGGAACCACGCCCTCGTGGACGGCAACAAGCGCATCGCCTGGTACGCGACCTGGGTCTTCCTG
CACATGAACGGACACCCGCTGGACGCGGACTTCGACGTGGACGAGGCCGAGACCTTCGTACTCGACGTCTGCCAGGGCGC
CTTGGACGTGCCGAAGATCGCGACACGGCTGCCGCGCTTCGCGCGCTGA

Antitoxin

Protein

• Length: 66 a.a.
• Molecular weight: 7208.03 Da
• Isoelectric Point: 5.5760

>AT37756 WP_055513929.1 NZ_AP023440:5916446-5916643 [Streptomyces glomeroaurantiacus]
MSGLNLRFTDEELDALRERAGAEGRSMQAFAHDAVISAINEHSRLFNEAAEHVLKASAELNRRLA

Nucleotide

• Length: 198 bp

>AT37756 NZ_AP023440:5916446-5916643 [Streptomyces glomeroaurantiacus]
ATGTCTGGATTGAACCTGCGGTTTACGGACGAAGAGCTCGACGCGTTGCGCGAGCGTGCGGGAGCGGAGGGGCGCAGCAT
GCAGGCCTTCGCCCACGACGCCGTGATCTCGGCCATAAACGAGCATTCGAGGCTGTTCAACGAAGCGGCCGAGCACGTCC
TGAAGGCGAGTGCCGAGCTGAACCGGAGGCTCGCCTGA