Detailed information of TA system TA037755

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 3577383..3577950
• Replicon: chromosome
• Accession: NZ_AP023440
• Organism: Streptomyces glomeroaurantiacus strain JCM 4677

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: IGS71_RS14720
• Protein ID: WP_190855281.1
• Coordinates: 3577687..3577950 (+)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: IGS71_RS14715
• Protein ID: WP_190850495.1
• Coordinates: 3577383..3577649 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IGS71_RS14695	3572604..3573254	-	651	WP_190850488.1	TetR/AcrR family transcriptional regulator	-
IGS71_RS14700	3573327..3574814	+	1488	WP_190850490.1	FAD-dependent oxidoreductase	-
IGS71_RS14705	3575026..3576339	-	1314	WP_190850492.1	hypothetical protein	-
IGS71_RS14710	3576339..3577013	-	675	WP_190850494.1	RNA polymerase sigma factor	-
IGS71_RS14715	3577383..3577649	+	267	WP_190850495.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
IGS71_RS14720	3577687..3577950	+	264	WP_190855281.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
IGS71_RS14725	3578040..3578948	-	909	WP_190850497.1	hypothetical protein	-
IGS71_RS14730	3578988..3579605	-	618	WP_190850498.1	RNA polymerase sigma factor	-
IGS71_RS14735	3579711..3580136	-	426	WP_190855283.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (6-59)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10049.53 Da
• Isoelectric Point: 8.4828

>T37755 WP_190855281.1 NZ_AP023440:3577687-3577950 [Streptomyces glomeroaurantiacus]
VSEYRTVFRPEAQAELRKIPRDMALRLLTKLTELESDPLGFSTTALVSQPDRRRLRVGDYRVIYTVDNGELVVWVVLVGH
RSTVYET

Nucleotide

• Length: 264 bp

>T37755 NZ_AP023440:3577687-3577950 [Streptomyces glomeroaurantiacus]
GTGAGTGAGTACCGCACCGTCTTCCGGCCCGAGGCACAGGCCGAACTCCGGAAGATCCCCCGCGACATGGCGCTGCGCCT
CCTGACCAAACTGACGGAGCTGGAGAGCGACCCGCTCGGATTCAGCACCACGGCACTCGTGTCCCAACCCGATCGCCGGC
GCCTCCGAGTCGGCGACTACCGCGTCATCTACACCGTCGACAACGGCGAACTGGTCGTATGGGTCGTTCTCGTCGGACAC
CGCTCCACCGTCTACGAGACGTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10187.58 Da
• Isoelectric Point: 4.9372

>AT37755 WP_190850495.1 NZ_AP023440:3577383-3577649 [Streptomyces glomeroaurantiacus]
MTQMPIESIRDVRAHLAEVVERADRDDQPTVITRRGKEVAAVVSIDVLRKYQQWEEREINRIIDERMANRSAGVPIEDVM
KETLARGE

Nucleotide

• Length: 267 bp

>AT37755 NZ_AP023440:3577383-3577649 [Streptomyces glomeroaurantiacus]
ATGACACAGATGCCCATAGAGTCCATCCGCGACGTCCGCGCGCACCTGGCCGAAGTCGTCGAGCGAGCCGATCGCGACGA
CCAGCCCACCGTGATCACGCGACGCGGAAAGGAAGTCGCCGCCGTCGTCTCGATCGACGTCCTGCGCAAGTACCAGCAGT
GGGAGGAGCGCGAGATCAATCGCATCATCGACGAACGGATGGCGAACCGCTCGGCCGGCGTCCCCATCGAGGACGTCATG
AAGGAAACGCTGGCACGCGGTGAATGA