Detailed information of TA system TA037754

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 3456598..3457139
• Replicon: chromosome
• Accession: NZ_AP023440
• Organism: Streptomyces glomeroaurantiacus strain JCM 4677

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: IGS71_RS14210
• Protein ID: WP_190850397.1
• Coordinates: 3456861..3457139 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: IGS71_RS14205
• Protein ID: WP_190855265.1
• Coordinates: 3456598..3456855 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IGS71_RS14190	3453430..3454143	+	714	WP_055510091.1	hemolysin III family protein	-
IGS71_RS14195	3454302..3455885	+	1584	WP_190850394.1	MFS transporter	-
IGS71_RS14200	3455890..3456510	+	621	WP_190850396.1	TetR family transcriptional regulator	-
IGS71_RS14205	3456598..3456855	+	258	WP_190855265.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
IGS71_RS14210	3456861..3457139	+	279	WP_190850397.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
IGS71_RS14215	3457231..3459705	-	2475	WP_190850399.1	DUF1929 domain-containing protein	-
IGS71_RS14220	3459705..3461021	-	1317	WP_190850401.1	glycosyltransferase family 2 protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-89)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-64)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10595.22 Da
• Isoelectric Point: 10.6656

>T37754 WP_190850397.1 NZ_AP023440:3456861-3457139 [Streptomyces glomeroaurantiacus]
VGHVTRFTPHAQRDMLKIPRPDALRILHRLSELQKAMDAHDTTAFDIKALQGHSARMRLRVGDFRVVYTVEDGQLVVWVF
TVGNRRDVYQGL

Nucleotide

• Length: 279 bp

>T37754 NZ_AP023440:3456861-3457139 [Streptomyces glomeroaurantiacus]
GTGGGTCACGTCACGCGGTTCACACCGCACGCCCAGCGGGACATGCTCAAGATTCCCCGGCCCGACGCCCTGCGGATCCT
CCACCGGCTCTCAGAACTCCAGAAGGCCATGGACGCGCATGACACCACCGCCTTCGACATCAAGGCGCTCCAAGGGCACA
GCGCCCGAATGCGCCTCCGGGTCGGCGACTTCCGCGTCGTGTACACGGTCGAGGACGGCCAACTCGTCGTATGGGTGTTC
ACGGTCGGGAACCGGCGAGACGTGTACCAAGGTCTGTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9561.65 Da
• Isoelectric Point: 4.9094

>AT37754 WP_190855265.1 NZ_AP023440:3456598-3456855 [Streptomyces glomeroaurantiacus]
MADVRRHLADVIDRAHRDETPTIITRRGKQEAVVIDIDEYRHLRALAEKTEDAWLNQLADEAEAEGVSGSVSLEEMAAAL
RTRHA

Nucleotide

• Length: 258 bp

>AT37754 NZ_AP023440:3456598-3456855 [Streptomyces glomeroaurantiacus]
ATGGCAGACGTCCGCAGGCATCTGGCGGACGTCATCGACCGCGCCCACCGGGACGAGACACCGACAATCATCACGCGTCG
CGGCAAGCAAGAGGCCGTGGTCATCGACATCGACGAGTACCGGCACCTGCGTGCACTCGCCGAGAAGACCGAGGACGCGT
GGCTGAACCAACTGGCCGACGAGGCGGAGGCCGAGGGAGTCTCCGGGTCCGTCTCCCTTGAGGAGATGGCCGCCGCGCTC
CGCACCCGTCACGCCTGA