Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 4919784..4920309 Replicon chromosome
Accession NZ_AP023439
Organism Streptomyces tuirus strain JCM 4255

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag IGS69_RS22760 Protein ID WP_190902387.1
Coordinates 4919784..4920047 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag IGS69_RS22765 Protein ID WP_190902388.1
Coordinates 4920040..4920309 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IGS69_RS22740 4915925..4916950 + 1026 WP_190902384.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -
IGS69_RS22745 4917019..4917765 + 747 WP_190902385.1 ROK family protein -
IGS69_RS22750 4917795..4918388 - 594 WP_190902386.1 hypothetical protein -
IGS69_RS22755 4918557..4919645 + 1089 WP_030842729.1 redox-regulated ATPase YchF -
IGS69_RS22760 4919784..4920047 - 264 WP_190902387.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IGS69_RS22765 4920040..4920309 - 270 WP_190902388.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IGS69_RS22770 4920392..4920793 - 402 WP_190902389.1 hypothetical protein -
IGS69_RS22775 4920781..4921407 - 627 WP_190904604.1 class F sortase -
IGS69_RS22780 4921433..4922260 - 828 WP_190902390.1 DUF4397 domain-containing protein -
IGS69_RS22785 4922358..4922981 - 624 WP_190902391.1 sigma-70 family RNA polymerase sigma factor -
IGS69_RS22790 4923144..4924241 + 1098 WP_190902392.1 MerR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-59)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10023.40 Da        Isoelectric Point: 9.5559

>T37753 WP_190902387.1 NZ_AP023439:c4920047-4919784 [Streptomyces tuirus]
VSEYRTVFRPEAQAELRKVPRDTALRILAKLAELESDPLGFNTTALVSQPDRRRLRVGDYRVIYTIDNGELVVWAVHVGH
RSRVYDT

Download         Length: 264 bp

>T37753 NZ_AP023439:c4920047-4919784 [Streptomyces tuirus]
GTGAGTGAGTACCGCACCGTCTTCCGTCCCGAGGCTCAGGCCGAGCTCCGCAAGGTGCCGCGGGACACGGCCCTCCGCAT
TCTGGCCAAGCTGGCCGAGCTGGAGAGCGACCCATTGGGGTTCAACACCACGGCCCTCGTCTCCCAGCCCGACCGACGCC
GCCTGCGGGTAGGCGACTACCGCGTGATCTACACGATCGACAACGGGGAGCTGGTGGTCTGGGCCGTGCACGTCGGGCAC
CGCTCCCGCGTCTACGACACCTGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10320.71 Da        Isoelectric Point: 4.7777

>AT37753 WP_190902388.1 NZ_AP023439:c4920309-4920040 [Streptomyces tuirus]
MTQPLPTESIRDVRAHLAEVVERADRDDVPTVITRRGKEVAAVVSIDVLRKYQEWEEREINRIIDERMANPAPGIPIEEI
MRETRARSE

Download         Length: 270 bp

>AT37753 NZ_AP023439:c4920309-4920040 [Streptomyces tuirus]
ATGACACAGCCGCTGCCCACAGAGTCAATCCGCGATGTCCGGGCACACCTGGCCGAGGTCGTGGAGCGGGCTGACCGCGA
CGACGTACCCACGGTGATCACGCGCAGAGGCAAGGAGGTGGCTGCCGTGGTGTCCATCGACGTGCTCCGGAAGTACCAGG
AGTGGGAAGAGCGCGAGATCAACCGGATCATCGACGAGCGCATGGCCAACCCGGCACCCGGCATCCCGATCGAAGAGATC
ATGAGGGAGACGCGGGCACGCAGTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References