Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-RelB
Location 3940435..3940970 Replicon chromosome
Accession NZ_AP023438
Organism Micromonospora sagamiensis strain JCM 3310

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag IGA62_RS17440 Protein ID WP_145819871.1
Coordinates 3940716..3940970 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag IGA62_RS17435 Protein ID WP_145819873.1
Coordinates 3940435..3940719 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IGA62_RS17410 3935947..3936750 - 804 WP_145819884.1 SGNH/GDSL hydrolase family protein -
IGA62_RS17415 3936747..3937916 - 1170 WP_145819882.1 SGNH/GDSL hydrolase family protein -
IGA62_RS17420 3938091..3938447 + 357 WP_145819879.1 DUF1232 domain-containing protein -
IGA62_RS17425 3938522..3939892 + 1371 WP_145819877.1 cystathionine beta-synthase -
IGA62_RS17430 3940037..3940267 - 231 WP_145819875.1 HIT domain-containing protein -
IGA62_RS17435 3940435..3940719 + 285 WP_145819873.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
IGA62_RS17440 3940716..3940970 + 255 WP_145819871.1 Txe/YoeB family addiction module toxin Toxin
IGA62_RS17445 3941208..3941726 - 519 WP_145819869.1 GNAT family N-acetyltransferase -
IGA62_RS17450 3941723..3942655 - 933 WP_145822163.1 ribonuclease Z -
IGA62_RS17455 3942974..3944179 - 1206 WP_145819867.1 osmoprotectant NAGGN system M42 family peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10273.58 Da        Isoelectric Point: 9.9423

>T37752 WP_145819871.1 NZ_AP023438:3940716-3940970 [Micromonospora sagamiensis]
VKVQFASRGWEDYLTWQRDRQMLKRVNALIEDIRRNGHQGIGKPEQLRGNWSGFWSRRIDQEHRLVYRIVDDTVQIAQCR
YHYE

Download         Length: 255 bp

>T37752 NZ_AP023438:3940716-3940970 [Micromonospora sagamiensis]
GTGAAGGTCCAGTTCGCCAGCCGGGGCTGGGAGGACTATCTGACCTGGCAACGGGATCGCCAGATGCTCAAGCGGGTGAA
CGCCCTGATCGAGGACATTCGACGCAACGGCCACCAGGGCATCGGCAAACCGGAGCAACTCCGCGGCAACTGGTCGGGAT
TCTGGTCGAGACGAATCGACCAGGAACACCGCCTGGTGTACCGGATCGTCGATGACACGGTGCAGATAGCGCAGTGCCGC
TATCACTACGAATGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10269.50 Da        Isoelectric Point: 4.4389

>AT37752 WP_145819873.1 NZ_AP023438:3940435-3940719 [Micromonospora sagamiensis]
MRIVPYSEVRQNLAKMLDHVVDDAEEIVVTRSGREAAVIISLREYESLKETAYLMASPANARRLNEAVEELRNGGGEMHD
LIDPNAGSGEASAA

Download         Length: 285 bp

>AT37752 NZ_AP023438:3940435-3940719 [Micromonospora sagamiensis]
ATGCGCATCGTTCCCTACTCAGAAGTCCGGCAGAACCTGGCAAAGATGCTTGACCATGTCGTGGACGATGCCGAGGAAAT
CGTGGTCACCCGCTCCGGCCGTGAGGCCGCCGTCATCATCTCGCTACGTGAGTACGAGTCGCTGAAGGAGACGGCATACC
TGATGGCCAGCCCCGCCAACGCGCGCCGTCTGAACGAAGCCGTCGAAGAGTTGCGCAACGGGGGTGGGGAGATGCACGAC
CTGATCGATCCCAACGCCGGCTCGGGCGAGGCGTCGGCAGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References