Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 3338161..3338786 Replicon chromosome
Accession NZ_AP023438
Organism Micromonospora sagamiensis strain JCM 3310

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag IGA62_RS14675 Protein ID WP_145820775.1
Coordinates 3338367..3338786 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag IGA62_RS14670 Protein ID WP_145820778.1
Coordinates 3338161..3338370 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IGA62_RS14645 3333270..3334733 + 1464 WP_145820787.1 menaquinone biosynthesis decarboxylase -
IGA62_RS14650 3334730..3335632 + 903 WP_145820784.1 4-hydroxybenzoate octaprenyltransferase -
IGA62_RS14655 3335682..3336638 - 957 WP_145820782.1 terpene synthase -
IGA62_RS14660 3336833..3337462 + 630 WP_145820780.1 UbiX family flavin prenyltransferase -
IGA62_RS14665 3337532..3337801 - 270 WP_088981116.1 BldC family transcriptional regulator -
IGA62_RS14670 3338161..3338370 + 210 WP_145820778.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
IGA62_RS14675 3338367..3338786 + 420 WP_145820775.1 PIN domain nuclease Toxin
IGA62_RS14680 3338705..3339472 - 768 WP_145820773.1 hypothetical protein -
IGA62_RS14685 3339757..3340215 + 459 WP_091455030.1 Lrp/AsnC family transcriptional regulator -
IGA62_RS14690 3340257..3341081 + 825 WP_145820771.1 SDR family NAD(P)-dependent oxidoreductase -
IGA62_RS14695 3341126..3342220 + 1095 WP_145820769.1 pyridoxal-phosphate dependent enzyme -
IGA62_RS14700 3342217..3342840 - 624 WP_145822223.1 putative glycolipid-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-119)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-44)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15345.53 Da        Isoelectric Point: 6.2163

>T37751 WP_145820775.1 NZ_AP023438:3338367-3338786 [Micromonospora sagamiensis]
VNHEHYLLDKSALARWPKPRVAPVLEELSECGLLAVCGAVEVEVIRSARTAKEAQRARWLLSGFRWLSMPDEVWDRAIDI
QVQALHKGNHRALSMADLLIAATAERHGATVLHYDGDFDLITAITGQPTTWVVPAGTAD

Download         Length: 420 bp

>T37751 NZ_AP023438:3338367-3338786 [Micromonospora sagamiensis]
GTGAACCACGAGCACTACCTGCTCGACAAGTCAGCCCTCGCCCGCTGGCCGAAGCCCCGTGTGGCTCCGGTGCTCGAAGA
ACTCTCCGAGTGTGGCCTGCTCGCGGTGTGCGGGGCGGTCGAGGTCGAGGTCATCCGCAGCGCCCGCACCGCCAAGGAGG
CCCAGCGTGCCCGGTGGCTGCTCAGCGGCTTCCGGTGGCTGTCGATGCCCGACGAAGTCTGGGATCGGGCGATCGACATC
CAGGTGCAGGCGCTTCACAAGGGCAACCACCGTGCGCTCTCCATGGCGGATCTGCTGATCGCGGCCACGGCCGAGCGGCA
TGGAGCCACCGTCCTGCACTACGACGGCGACTTCGACCTGATCACCGCGATCACCGGCCAGCCCACCACCTGGGTCGTTC
CGGCCGGGACCGCCGACTGA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 7333.37 Da        Isoelectric Point: 6.2813

>AT37751 WP_145820778.1 NZ_AP023438:3338161-3338370 [Micromonospora sagamiensis]
VSRTILDVDDELLAEAGKILGTTTKKATVNAALKAVVDREKRRQFADWLKSGGLPDLTGPVEATKPDAA

Download         Length: 210 bp

>AT37751 NZ_AP023438:3338161-3338370 [Micromonospora sagamiensis]
GTGAGCCGGACCATCCTTGACGTCGATGACGAGCTACTTGCCGAGGCCGGAAAGATCCTCGGCACCACCACGAAGAAGGC
CACCGTCAACGCTGCCCTCAAGGCGGTCGTCGACCGGGAGAAACGGCGGCAGTTCGCGGACTGGCTGAAGAGTGGAGGGC
TGCCCGATCTGACCGGCCCGGTCGAGGCGACCAAGCCGGACGCGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References