Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/Doc-Phd |
| Location | 65866..66467 | Replicon | plasmid pM71903 |
| Accession | NZ_AP023436 | ||
| Organism | Escherichia coli strain M719 | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | U9YA20 |
| Locus tag | M2043_RS25120 | Protein ID | WP_001216045.1 |
| Coordinates | 65866..66246 (-) | Length | 127 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | U9YQH9 |
| Locus tag | M2043_RS25125 | Protein ID | WP_001190712.1 |
| Coordinates | 66246..66467 (-) | Length | 74 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| M2043_RS25090 (MYEC719_p30062) | 61309..62109 | - | 801 | WP_248537786.1 | hypothetical protein | - |
| M2043_RS25095 (MYEC719_p30063) | 62433..62792 | - | 360 | WP_248537788.1 | hypothetical protein | - |
| M2043_RS25100 | 62792..63983 | - | 1192 | Protein_60 | terminase | - |
| M2043_RS25105 (MYEC719_p30066) | 64070..64522 | - | 453 | WP_001369802.1 | hypothetical protein | - |
| M2043_RS25110 (MYEC719_p30067) | 64611..65654 | - | 1044 | WP_000648823.1 | DUF968 domain-containing protein | - |
| M2043_RS25115 (MYEC719_p30068) | 65682..65861 | - | 180 | WP_000113019.1 | hypothetical protein | - |
| M2043_RS25120 (MYEC719_p30069) | 65866..66246 | - | 381 | WP_001216045.1 | type II toxin-antitoxin system death-on-curing family toxin | Toxin |
| M2043_RS25125 (MYEC719_p30070) | 66246..66467 | - | 222 | WP_001190712.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| M2043_RS25130 (MYEC719_p30071) | 66540..66927 | - | 388 | Protein_66 | S24 family peptidase | - |
| M2043_RS25135 | 66988..68203 | - | 1216 | Protein_67 | ISL3-like element ISKox3 family transposase | - |
| M2043_RS25140 (MYEC719_p30075) | 68370..68621 | - | 252 | WP_001377386.1 | DNA polymerase III subunit theta | - |
| M2043_RS25145 (MYEC719_p30077) | 69066..69203 | + | 138 | WP_000123562.1 | hypothetical protein | - |
| M2043_RS25150 (MYEC719_p30078) | 69278..69424 | - | 147 | WP_001345500.1 | hypothetical protein | - |
| M2043_RS25155 (MYEC719_p30080) | 69636..70289 | - | 654 | WP_248537790.1 | hypothetical protein | - |
| M2043_RS25160 (MYEC719_p30081) | 70352..70543 | - | 192 | WP_248537792.1 | hypothetical protein | - |
| M2043_RS25165 (MYEC719_p30082) | 70525..70899 | - | 375 | WP_023154376.1 | hypothetical protein | - |
| M2043_RS25170 (MYEC719_p30083) | 70906..71199 | - | 294 | WP_001677496.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..118399 | 118399 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 127 a.a. Molecular weight: 13588.29 Da Isoelectric Point: 5.1514
>T37749 WP_001216045.1 NZ_AP023436:c66246-65866 [Escherichia coli]
MRHISPEELIALHDANISRYGGLPGMSDPGRAEAIIGRVQARVAYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELADLTVGAATGEISVSSVADTLRRLYGSAE
MRHISPEELIALHDANISRYGGLPGMSDPGRAEAIIGRVQARVAYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELADLTVGAATGEISVSSVADTLRRLYGSAE
Download Length: 381 bp
>T37749 NZ_AP023436:c66246-65866 [Escherichia coli]
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAGCCGCTACGGCGGCCTGCCGGGAATGTC
TGATCCGGGTAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTGGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGCTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACTGTAGGCGCTGCGACTGG
CGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCTGCGGAGTAG
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAGCCGCTACGGCGGCCTGCCGGGAATGTC
TGATCCGGGTAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTGGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGCTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACTGTAGGCGCTGCGACTGG
CGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCTGCGGAGTAG
Antitoxin
Download Length: 74 a.a. Molecular weight: 8133.10 Da Isoelectric Point: 4.7708
>AT37749 WP_001190712.1 NZ_AP023436:c66467-66246 [Escherichia coli]
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR
Download Length: 222 bp
>AT37749 NZ_AP023436:c66467-66246 [Escherichia coli]
ATGCAATCCATTAACTTCCGTACCGCGCGTGGCAACCTTTCTGAAGTGCTCAACAATGTTGAAGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA
ATGCAATCCATTAACTTCCGTACCGCGCGTGGCAACCTTTCTGAAGTGCTCAACAATGTTGAAGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A829CLP7 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A829CJB6 |