Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/YafQ-DinJ |
| Location | 2586039..2586604 | Replicon | chromosome |
| Accession | NZ_AP023420 | ||
| Organism | Pusillibacter faecalis strain MM59 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | C7H6P5 |
| Locus tag | KJS55_RS12960 | Protein ID | WP_002596328.1 |
| Coordinates | 2586314..2586604 (+) | Length | 97 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | C7H6P4 |
| Locus tag | KJS55_RS12955 | Protein ID | WP_005924829.1 |
| Coordinates | 2586039..2586317 (+) | Length | 93 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KJS55_RS12915 (MM59RIKEN_26130) | 2581127..2581648 | - | 522 | WP_003505403.1 | AAA family ATPase | - |
| KJS55_RS12920 (MM59RIKEN_26140) | 2581911..2582051 | - | 141 | WP_087214640.1 | Maff2 family protein | - |
| KJS55_RS12925 (MM59RIKEN_26150) | 2582137..2583015 | - | 879 | Protein_2541 | TraG/TraD/VirD4 family protein | - |
| KJS55_RS12930 (MM59RIKEN_26160) | 2583111..2583476 | - | 366 | WP_118280944.1 | hypothetical protein | - |
| KJS55_RS12935 (MM59RIKEN_26170) | 2583554..2583748 | - | 195 | WP_069432571.1 | transposon-encoded TnpW family protein | - |
| KJS55_RS12940 (MM59RIKEN_26180) | 2583792..2584655 | - | 864 | WP_213543463.1 | ATP-binding protein | - |
| KJS55_RS12945 (MM59RIKEN_26190) | 2584652..2585401 | - | 750 | WP_213543464.1 | phage replisome organizer N-terminal domain-containing protein | - |
| KJS55_RS12950 (MM59RIKEN_26200) | 2585514..2585912 | - | 399 | WP_031475896.1 | cysteine-rich VLP domain-containing protein | - |
| KJS55_RS12955 (MM59RIKEN_26210) | 2586039..2586317 | + | 279 | WP_005924829.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| KJS55_RS12960 (MM59RIKEN_26220) | 2586314..2586604 | + | 291 | WP_002596328.1 | type II toxin-antitoxin system YafQ family toxin | Toxin |
| KJS55_RS12965 (MM59RIKEN_26230) | 2586712..2588157 | - | 1446 | WP_213543465.1 | MobQ family relaxase | - |
| KJS55_RS12970 (MM59RIKEN_26240) | 2588344..2588634 | - | 291 | WP_107630807.1 | DUF3847 domain-containing protein | - |
| KJS55_RS12975 (MM59RIKEN_26250) | 2588663..2589124 | - | 462 | WP_118556432.1 | sigma factor-like helix-turn-helix DNA-binding protein | - |
| KJS55_RS12980 (MM59RIKEN_26260) | 2589135..2589587 | - | 453 | WP_176256120.1 | RNA polymerase subunit sigma-24 | - |
| KJS55_RS12985 (MM59RIKEN_26270) | 2589691..2590104 | - | 414 | WP_176256121.1 | sigma factor-like helix-turn-helix DNA-binding protein | - |
| KJS55_RS12990 | 2590628..2590813 | - | 186 | WP_117510411.1 | cysteine-rich KTR domain-containing protein | - |
| KJS55_RS12995 (MM59RIKEN_26280) | 2590815..2591237 | - | 423 | WP_176256122.1 | YjdF family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | tet(W) | - | 2577377..2609260 | 31883 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 97 a.a. Molecular weight: 11112.87 Da Isoelectric Point: 8.0630
>T37697 WP_002596328.1 NZ_AP023420:2586314-2586604 [Pusillibacter faecalis]
MKETKYTVKYTTSFKKDYKRAIKRGLKIELLEQVVALLAMGEPLPDKNRDHDLSGDWAGHRECHILPDWLLVYRIEDDVL
VLTLARTGTHSDLFGK
MKETKYTVKYTTSFKKDYKRAIKRGLKIELLEQVVALLAMGEPLPDKNRDHDLSGDWAGHRECHILPDWLLVYRIEDDVL
VLTLARTGTHSDLFGK
Download Length: 291 bp
>T37697 NZ_AP023420:2586314-2586604 [Pusillibacter faecalis]
ATGAAAGAAACCAAATATACCGTCAAGTACACGACCAGTTTCAAAAAAGACTACAAACGAGCCATAAAGCGTGGCTTGAA
GATTGAGCTGCTGGAGCAGGTCGTAGCATTGCTGGCAATGGGCGAACCGCTGCCGGATAAGAACCGCGACCATGACCTGT
CCGGCGATTGGGCGGGCCATCGGGAATGTCATATTCTCCCGGACTGGCTGCTTGTCTATCGCATAGAGGATGATGTTCTG
GTGCTGACGCTGGCCCGCACCGGCACACACAGCGACTTGTTCGGCAAATAA
ATGAAAGAAACCAAATATACCGTCAAGTACACGACCAGTTTCAAAAAAGACTACAAACGAGCCATAAAGCGTGGCTTGAA
GATTGAGCTGCTGGAGCAGGTCGTAGCATTGCTGGCAATGGGCGAACCGCTGCCGGATAAGAACCGCGACCATGACCTGT
CCGGCGATTGGGCGGGCCATCGGGAATGTCATATTCTCCCGGACTGGCTGCTTGTCTATCGCATAGAGGATGATGTTCTG
GTGCTGACGCTGGCCCGCACCGGCACACACAGCGACTTGTTCGGCAAATAA
Antitoxin
Download Length: 93 a.a. Molecular weight: 10247.66 Da Isoelectric Point: 4.4692
>AT37697 WP_005924829.1 NZ_AP023420:2586039-2586317 [Pusillibacter faecalis]
MAGNTTNISIRMDADLKAQADALFTELGMNLTTAFNIFVRQSLREGGIPFEVRLEQPNKETVAAMLEAERIAKDPSVKGY
NDLDELFADLKR
MAGNTTNISIRMDADLKAQADALFTELGMNLTTAFNIFVRQSLREGGIPFEVRLEQPNKETVAAMLEAERIAKDPSVKGY
NDLDELFADLKR
Download Length: 279 bp
>AT37697 NZ_AP023420:2586039-2586317 [Pusillibacter faecalis]
ATGGCTGGAAATACCACAAACATCAGTATCCGCATGGACGCAGATTTGAAAGCGCAGGCGGACGCACTGTTTACTGAACT
TGGCATGAACCTGACTACGGCGTTTAACATCTTTGTGCGCCAGTCGCTTCGTGAAGGCGGCATTCCCTTTGAGGTAAGGC
TGGAACAGCCGAACAAAGAAACGGTTGCTGCCATGCTGGAAGCGGAAAGGATTGCAAAAGACCCGTCTGTAAAGGGCTAC
AATGACCTTGACGAGTTGTTTGCTGACCTGAAAAGATGA
ATGGCTGGAAATACCACAAACATCAGTATCCGCATGGACGCAGATTTGAAAGCGCAGGCGGACGCACTGTTTACTGAACT
TGGCATGAACCTGACTACGGCGTTTAACATCTTTGTGCGCCAGTCGCTTCGTGAAGGCGGCATTCCCTTTGAGGTAAGGC
TGGAACAGCCGAACAAAGAAACGGTTGCTGCCATGCTGGAAGCGGAAAGGATTGCAAAAGACCCGTCTGTAAAGGGCTAC
AATGACCTTGACGAGTTGTTTGCTGACCTGAAAAGATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1M4XBM1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1M4XB19 |