Detailed information of TA system TA037696

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): paaR-paaA-parE/RelE(toxin)
• Location: 1182..1654
• Replicon: plasmid pAACEN3
• Accession: NZ_AP023413
• Organism: Acetobacter aceti NBRC 14818

Toxin (Protein)

• Gene name: parE_1
• Uniprot ID: A0A0D6MXE0
• Locus tag: EMQ_RS17000
• Protein ID: WP_010668485.1
• Coordinates: 1373..1654 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: paaA
• Uniprot ID: -
• Locus tag: EMQ_RS16995
• Protein ID: WP_010668484.1
• Coordinates: 1182..1373 (+)
• Length: 64 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EMQ_RS16985	270..737	+	468	WP_018308605.1	helix-turn-helix domain-containing protein	-
EMQ_RS16990	734..1135	+	402	WP_082066655.1	helix-turn-helix domain-containing protein	-
EMQ_RS16995	1182..1373	+	192	WP_010668484.1	hypothetical protein	Antitoxin
EMQ_RS17000	1373..1654	+	282	WP_010668485.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EMQ_RS17005	1659..1919	-	261	WP_132012125.1	hypothetical protein	-
EMQ_RS17010	1949..2398	+	450	WP_048874234.1	hypothetical protein	-
EMQ_RS17015	2530..3846	-	1317	WP_018308602.1	hypothetical protein	-
EMQ_RS17020	3966..4499	+	534	WP_018308601.1	RNA 2'-phosphotransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..4858	4858

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-110)

Antitoxin

• Antitoxin CbeA (5-103)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 12066.38 Da
• Isoelectric Point: 12.7685

>T37696 WP_010668485.1 NZ_AP023413:1373-1654 [Acetobacter aceti NBRC 14818]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKK

Nucleotide

• Length: 282 bp

>T37696 NZ_AP023413:1373-1654 [Acetobacter aceti NBRC 14818]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin

Protein

• Length: 64 a.a.
• Molecular weight: 8221.16 Da
• Isoelectric Point: 12.5993

>AT37696 WP_010668484.1 NZ_AP023413:1182-1373 [Acetobacter aceti NBRC 14818]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 192 bp

>AT37696 NZ_AP023413:1182-1373 [Acetobacter aceti NBRC 14818]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Structures

Toxin

• AlphaFold DB: A0A0D6MXE0