Detailed information of TA system TA037693

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 39492..40174
• Replicon: plasmid pFMUON74
• Accession: NZ_AP023397
• Organism: Nocardia wallacei strain FMUON74

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: NWFMUON74_RS35430
• Protein ID: WP_187689643.1
• Coordinates: 39492..39920 (-)
• Length: 143 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: NWFMUON74_RS35435
• Protein ID: WP_187689644.1
• Coordinates: 39917..40174 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NWFMUON74_RS35395	35159..35746	+	588	WP_187689636.1	HD domain-containing protein	-
NWFMUON74_RS35400	36001..36594	+	594	WP_187689637.1	GNAT family N-acetyltransferase	-
NWFMUON74_RS35405	36607..37041	+	435	WP_187689638.1	hypothetical protein	-
NWFMUON74_RS35410	37038..37274	-	237	WP_187689639.1	hypothetical protein	-
NWFMUON74_RS35415	37364..38383	-	1020	WP_187689640.1	site-specific integrase	-
NWFMUON74_RS35420	38449..38838	-	390	WP_187689641.1	hypothetical protein	-
NWFMUON74_RS35425	39025..39432	-	408	WP_187689642.1	hypothetical protein	-
NWFMUON74_RS35430	39492..39920	-	429	WP_187689643.1	PIN domain-containing protein	Toxin
NWFMUON74_RS35435	39917..40174	-	258	WP_187689644.1	hypothetical protein	Antitoxin
NWFMUON74_RS35440	40363..40707	-	345	WP_187689645.1	hypothetical protein	-
NWFMUON74_RS35445	40843..41025	+	183	WP_187689646.1	hypothetical protein	-
NWFMUON74_RS35450	41109..41282	-	174	WP_187689647.1	hypothetical protein	-
NWFMUON74_RS35455	41506..42069	-	564	WP_187689648.1	hypothetical protein	-
NWFMUON74_RS35460	42171..42596	-	426	WP_187689649.1	hypothetical protein	-
NWFMUON74_RS35465	42625..42861	-	237	WP_187689650.1	hypothetical protein	-
NWFMUON74_RS35470	43400..43684	+	285	WP_187689651.1	hypothetical protein	-
NWFMUON74_RS35475	43704..44009	-	306	WP_187689652.1	hypothetical protein	-
NWFMUON74_RS35480	44111..44536	-	426	WP_187689653.1	hypothetical protein	-
NWFMUON74_RS35485	44626..44847	-	222	WP_187689654.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..60434	60434

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-124)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 143 a.a.
• Molecular weight: 15182.09 Da
• Isoelectric Point: 4.5271

>T37693 WP_187689643.1 NZ_AP023397:c39920-39492 [Nocardia wallacei]
VIILDTNVISEPFAKNPDLRVAAWFDAQSAETLYLTTVTVGELRYGIAAMPAGRRRDEYAAWLEDRTLPAFSGRILSYDL
AATTEYARLRAAARAAGLAVATADGMIAATAAAAGFTVATRDTSPFEAAGVPTIDPWQSEQR

Nucleotide

• Length: 429 bp

>T37693 NZ_AP023397:c39920-39492 [Nocardia wallacei]
GTGATCATCCTGGACACCAACGTCATCAGCGAACCGTTCGCCAAGAACCCCGACCTGCGGGTAGCGGCATGGTTCGACGC
ACAGAGCGCCGAAACCCTCTACCTGACCACCGTCACCGTCGGCGAACTCCGCTACGGGATCGCGGCCATGCCCGCCGGCC
GACGCCGCGACGAATACGCCGCATGGCTCGAAGACCGCACCCTGCCCGCGTTCTCCGGCCGCATCCTCTCCTATGACCTG
GCCGCCACCACCGAATACGCGCGCCTGCGCGCCGCCGCCCGCGCCGCAGGGCTCGCCGTCGCCACCGCGGACGGCATGAT
CGCCGCCACGGCGGCCGCCGCAGGCTTCACCGTCGCCACCCGCGACACCTCGCCGTTCGAGGCCGCCGGAGTGCCCACCA
TCGACCCGTGGCAATCGGAGCAACGATGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9701.84 Da
• Isoelectric Point: 5.2082

>AT37693 WP_187689644.1 NZ_AP023397:c40174-39917 [Nocardia wallacei]
MKNVTIRNLSDEVHRAIRQRAAGNERSIEAEMRAILSDAVQPAERIKLGSLLFAGISEENRLTDDERETYFGRDRTPSEP
LEFGR

Nucleotide

• Length: 258 bp

>AT37693 NZ_AP023397:c40174-39917 [Nocardia wallacei]
ATGAAGAACGTGACGATCCGAAATCTGTCCGACGAAGTGCACCGCGCCATCCGCCAGCGCGCGGCCGGGAACGAACGCAG
CATCGAAGCCGAGATGCGCGCCATCCTCAGCGACGCCGTACAACCGGCCGAGCGGATCAAACTCGGCAGCCTCCTGTTCG
CGGGCATCAGCGAAGAGAACCGGCTCACCGACGACGAACGCGAAACCTACTTCGGCCGCGACCGCACCCCGTCCGAACCG
CTGGAGTTCGGCCGGTGA