Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 2059902..2060388 Replicon chromosome
Accession NZ_AP023394
Organism Streptococcus dysgalactiae subsp. equisimilis strain 159

Toxin (Protein)


Gene name relE Uniprot ID Q48QR0
Locus tag H7680_RS10035 Protein ID WP_014407961.1
Coordinates 2059902..2060171 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A660A1J7
Locus tag H7680_RS10040 Protein ID WP_014407962.1
Coordinates 2060161..2060388 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7680_RS10020 2055034..2057307 - 2274 WP_003059575.1 YhgE/Pip domain-containing protein -
H7680_RS10025 2057442..2057975 + 534 WP_003059589.1 TetR/AcrR family transcriptional regulator C-terminal domain-containing protein -
H7680_RS10030 2057972..2059474 - 1503 WP_184006747.1 IS1182 family transposase -
H7680_RS10035 2059902..2060171 - 270 WP_014407961.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H7680_RS10040 2060161..2060388 - 228 WP_014407962.1 hypothetical protein Antitoxin
H7680_RS10045 2060525..2060911 - 387 WP_012767655.1 DUF1492 domain-containing protein -
H7680_RS10050 2060886..2061248 - 363 WP_012767656.1 DUF1492 domain-containing protein -
H7680_RS10055 2061519..2061740 - 222 WP_012767657.1 hypothetical protein -
H7680_RS10060 2061717..2061988 - 272 Protein_1924 hypothetical protein -
H7680_RS10065 2061978..2062316 - 339 WP_012767659.1 hypothetical protein -
H7680_RS10070 2062399..2062647 - 249 WP_012767660.1 hypothetical protein -
H7680_RS10075 2062657..2063442 - 786 WP_012767661.1 hypothetical protein -
H7680_RS10080 2063531..2063680 - 150 WP_012767662.1 hypothetical protein -
H7680_RS10085 2063694..2063939 - 246 WP_012767663.1 hypothetical protein -
H7680_RS10090 2063935..2064261 - 327 Protein_1930 hypothetical protein -
H7680_RS10095 2064263..2064436 - 174 WP_012767665.1 hypothetical protein -
H7680_RS10100 2064442..2064615 - 174 WP_003045773.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2024220..2096722 72502
- flank IS/Tn - - 2057972..2059474 1502


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10497.50 Da        Isoelectric Point: 10.5027

>T37692 WP_014407961.1 NZ_AP023394:c2060171-2059902 [Streptococcus dysgalactiae subsp. equisimilis]
MTYKLVVSDEVKKQLKKMDKHVGLMLAKDMKKRLDGLNNPRQFGKALTGQYKGLWRYRVGNYRVICDIVDNEMIILALEV
GHRKEIYKR

Download         Length: 270 bp

>T37692 NZ_AP023394:c2060171-2059902 [Streptococcus dysgalactiae subsp. equisimilis]
ATGACTTATAAGCTAGTGGTGAGTGATGAAGTCAAGAAGCAACTCAAAAAGATGGATAAGCATGTAGGGCTTATGTTAGC
CAAAGACATGAAGAAACGACTTGACGGGTTAAATAATCCTAGACAATTTGGAAAAGCCCTCACAGGTCAATATAAAGGGC
TTTGGCGCTATCGTGTTGGTAATTATCGGGTGATTTGTGACATTGTGGATAATGAAATGATTATCCTTGCTTTGGAAGTT
GGACACAGGAAAGAGATATACAAGCGCTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8641.63 Da        Isoelectric Point: 3.9607

>AT37692 WP_014407962.1 NZ_AP023394:c2060388-2060161 [Streptococcus dysgalactiae subsp. equisimilis]
MAMVSLRLNSAEEELFRSYATHTGKTLSELFKTALAQQIEDQLDYETGIQALKRFEENPITYSIDDLIEELENDL

Download         Length: 228 bp

>AT37692 NZ_AP023394:c2060388-2060161 [Streptococcus dysgalactiae subsp. equisimilis]
ATGGCAATGGTATCATTAAGACTGAACAGTGCAGAGGAAGAGCTTTTCAGAAGCTACGCTACACATACAGGCAAAACATT
ATCTGAATTATTCAAGACAGCACTAGCGCAACAAATTGAAGATCAATTGGACTATGAAACAGGTATTCAAGCTTTAAAAC
GCTTTGAAGAAAATCCTATAACTTATTCTATCGATGATTTAATTGAGGAGTTGGAAAATGACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A660A202

Antitoxin

Source ID Structure
AlphaFold DB A0A660A1J7

References