Detailed information of TA system TA037691

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelB(antitoxin)
• Location: 587068..587686
• Replicon: chromosome
• Accession: NZ_AP023394
• Organism: Streptococcus dysgalactiae subsp. equisimilis strain 159

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: H7680_RS03085
• Protein ID: WP_003058081.1
• Coordinates: 587068..587409 (-)
• Length: 114 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: H7680_RS03090
• Protein ID: WP_003058067.1
• Coordinates: 587399..587686 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H7680_RS03065	582531..583775	-	1245	WP_014612120.1	site-specific integrase	-
H7680_RS03070	583786..583983	-	198	WP_003058094.1	transposase	-
H7680_RS03075	584003..585106	-	1104	WP_003058088.1	CHAP domain-containing protein	-
H7680_RS03080	585109..587010	-	1902	WP_184006803.1	hypothetical protein	-
H7680_RS03085	587068..587409	-	342	WP_003058081.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
H7680_RS03090	587399..587686	-	288	WP_003058067.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
H7680_RS03095	587757..590255	-	2499	WP_003058044.1	ATP-binding protein	-
H7680_RS03100	590239..590655	-	417	WP_003058056.1	conjugal transfer protein	-
H7680_RS03105	590664..590882	-	219	WP_003058071.1	hypothetical protein	-
H7680_RS03110	590879..591820	-	942	WP_003058075.1	conjugal transfer protein	-
H7680_RS03115	591833..592096	-	264	WP_003058063.1	hypothetical protein	-
H7680_RS03120	592106..592378	-	273	WP_003058046.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	tufA	540624..661411	120787

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-100)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (11-90)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 13438.41 Da
• Isoelectric Point: 7.0067

>T37691 WP_003058081.1 NZ_AP023394:c587409-587068 [Streptococcus dysgalactiae subsp. equisimilis]
MAYNVQITKSAERDLDSIYQFYLDEFSEQSALKVIKSLQDAISFLYVSPLGYTDFDSKINRKIYPQGNLRMIPSKQYLIF
YLIREERVDVLRIIHSRTDYLNNLENLFKNLNL

Nucleotide

• Length: 342 bp

>T37691 NZ_AP023394:c587409-587068 [Streptococcus dysgalactiae subsp. equisimilis]
ATGGCCTATAATGTACAAATTACCAAAAGTGCCGAGAGAGATCTAGACAGTATCTATCAGTTCTATCTAGATGAATTTTC
TGAACAAAGTGCTTTGAAAGTTATCAAAAGCCTTCAAGATGCTATCAGCTTTCTTTATGTTTCACCACTTGGCTACACCG
ACTTCGATTCTAAAATCAATCGAAAAATTTATCCACAAGGTAATCTAAGAATGATTCCTTCAAAGCAATACCTTATTTTT
TATCTTATCCGTGAAGAAAGGGTAGATGTTTTAAGAATTATTCATTCTAGAACAGATTATCTCAATAATTTAGAAAATCT
CTTTAAAAATCTAAACCTTTAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10869.33 Da
• Isoelectric Point: 4.3885

>AT37691 WP_003058067.1 NZ_AP023394:c587686-587399 [Streptococcus dysgalactiae subsp. equisimilis]
MNTLARDRQYNFRVNADMLNQAKEILEEKHMSLPDALNLFVEQVVVTKDLPIKTPEQVQAESFLNELISELDEGYQDVLK
GNTKPANEVFAKYGL

Nucleotide

• Length: 288 bp

>AT37691 NZ_AP023394:c587686-587399 [Streptococcus dysgalactiae subsp. equisimilis]
ATGAATACACTAGCAAGAGATCGCCAATATAATTTCCGTGTCAATGCGGATATGCTAAATCAGGCTAAGGAAATTTTGGA
GGAAAAACATATGTCTCTACCTGATGCTCTTAATTTATTTGTAGAGCAAGTGGTTGTCACTAAAGACCTCCCTATCAAAA
CACCTGAGCAAGTTCAAGCTGAATCTTTCTTAAATGAATTAATTTCAGAACTTGATGAAGGCTATCAAGATGTTCTAAAA
GGAAATACAAAACCAGCTAATGAGGTTTTTGCAAAATATGGCCTATAA