Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 2108918..2109404 Replicon chromosome
Accession NZ_AP023393
Organism Streptococcus dysgalactiae subsp. equisimilis strain 89

Toxin (Protein)


Gene name relE Uniprot ID Q48QR0
Locus tag H7678_RS10280 Protein ID WP_014407961.1
Coordinates 2108918..2109187 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A660A1J7
Locus tag H7678_RS10285 Protein ID WP_014407962.1
Coordinates 2109177..2109404 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7678_RS10265 2104257..2106530 - 2274 WP_046178065.1 YhgE/Pip domain-containing protein -
H7678_RS10270 2106665..2107198 + 534 WP_003059589.1 TetR/AcrR family transcriptional regulator C-terminal domain-containing protein -
H7678_RS10275 2107226..2108590 - 1365 Protein_1969 IS1182 family transposase -
H7678_RS10280 2108918..2109187 - 270 WP_014407961.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H7678_RS10285 2109177..2109404 - 228 WP_014407962.1 hypothetical protein Antitoxin
H7678_RS10290 2109541..2109927 - 387 WP_046177961.1 DUF1492 domain-containing protein -
H7678_RS10295 2109902..2110264 - 363 WP_046177962.1 DUF1492 domain-containing protein -
H7678_RS10300 2110503..2110724 - 222 WP_046177979.1 hypothetical protein -
H7678_RS10305 2110724..2110972 - 249 WP_100249571.1 hypothetical protein -
H7678_RS10310 2110962..2111300 - 339 WP_037580661.1 hypothetical protein -
H7678_RS10315 2111371..2111631 - 261 WP_046177963.1 hypothetical protein -
H7678_RS10320 2111641..2112426 - 786 WP_046177964.1 hypothetical protein -
H7678_RS10325 2112516..2112665 - 150 WP_162836006.1 hypothetical protein -
H7678_RS10330 2112679..2112924 - 246 WP_015058152.1 hypothetical protein -
H7678_RS10335 2112899..2113036 - 138 WP_158001818.1 hypothetical protein -
H7678_RS10340 2113038..2113211 - 174 WP_046177965.1 hypothetical protein -
H7678_RS10345 2113217..2113390 - 174 WP_046177966.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2087020..2138180 51160
- flank IS/Tn - - 2107607..2108623 1016


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10497.50 Da        Isoelectric Point: 10.5027

>T37690 WP_014407961.1 NZ_AP023393:c2109187-2108918 [Streptococcus dysgalactiae subsp. equisimilis]
MTYKLVVSDEVKKQLKKMDKHVGLMLAKDMKKRLDGLNNPRQFGKALTGQYKGLWRYRVGNYRVICDIVDNEMIILALEV
GHRKEIYKR

Download         Length: 270 bp

>T37690 NZ_AP023393:c2109187-2108918 [Streptococcus dysgalactiae subsp. equisimilis]
ATGACTTATAAGCTAGTGGTGAGTGATGAAGTCAAGAAGCAACTCAAAAAGATGGATAAGCATGTAGGGCTTATGTTAGC
CAAAGACATGAAGAAACGACTTGACGGGTTAAATAATCCTAGACAATTTGGAAAAGCCCTCACAGGTCAATATAAAGGGC
TTTGGCGCTATCGTGTTGGTAATTATCGGGTGATTTGTGACATTGTGGATAATGAAATGATTATCCTTGCTTTGGAAGTT
GGACACAGGAAAGAGATATACAAGCGCTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8641.63 Da        Isoelectric Point: 3.9607

>AT37690 WP_014407962.1 NZ_AP023393:c2109404-2109177 [Streptococcus dysgalactiae subsp. equisimilis]
MAMVSLRLNSAEEELFRSYATHTGKTLSELFKTALAQQIEDQLDYETGIQALKRFEENPITYSIDDLIEELENDL

Download         Length: 228 bp

>AT37690 NZ_AP023393:c2109404-2109177 [Streptococcus dysgalactiae subsp. equisimilis]
ATGGCAATGGTATCATTAAGACTGAACAGTGCAGAGGAAGAGCTTTTCAGAAGCTACGCTACACATACAGGCAAAACATT
ATCTGAATTATTCAAGACAGCACTAGCGCAACAAATTGAAGATCAATTGGACTATGAAACAGGTATTCAAGCTTTAAAAC
GCTTTGAAGAAAATCCTATAACTTATTCTATCGATGATTTAATTGAGGAGTTGGAAAATGACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A660A202

Antitoxin

Source ID Structure
AlphaFold DB A0A660A1J7

References