Detailed information of TA system TA037688

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelB(antitoxin)
• Location: 591550..592168
• Replicon: chromosome
• Accession: NZ_AP023393
• Organism: Streptococcus dysgalactiae subsp. equisimilis strain 89

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: H7678_RS03120
• Protein ID: WP_003058081.1
• Coordinates: 591550..591891 (-)
• Length: 114 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: H7678_RS03125
• Protein ID: WP_003058067.1
• Coordinates: 591881..592168 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H7678_RS03100	587013..588257	-	1245	WP_014612120.1	site-specific integrase	-
H7678_RS03105	588268..588465	-	198	WP_003058094.1	transposase	-
H7678_RS03110	588485..589588	-	1104	WP_014612121.1	CHAP domain-containing protein	-
H7678_RS03115	589591..591492	-	1902	WP_003058051.1	hypothetical protein	-
H7678_RS03120	591550..591891	-	342	WP_003058081.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
H7678_RS03125	591881..592168	-	288	WP_003058067.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
H7678_RS03130	592239..594737	-	2499	WP_065355266.1	ATP-binding protein	-
H7678_RS03135	594721..595137	-	417	WP_003058056.1	conjugal transfer protein	-
H7678_RS03140	595146..595364	-	219	WP_003058071.1	hypothetical protein	-
H7678_RS03145	595361..596302	-	942	WP_003058075.1	conjugal transfer protein	-
H7678_RS03150	596315..596578	-	264	WP_003058063.1	hypothetical protein	-
H7678_RS03155	596588..596860	-	273	WP_003058046.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	psaA / tufA	433454..674342	240888

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-100)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (11-90)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 13438.41 Da
• Isoelectric Point: 7.0067

>T37688 WP_003058081.1 NZ_AP023393:c591891-591550 [Streptococcus dysgalactiae subsp. equisimilis]
MAYNVQITKSAERDLDSIYQFYLDEFSEQSALKVIKSLQDAISFLYVSPLGYTDFDSKINRKIYPQGNLRMIPSKQYLIF
YLIREERVDVLRIIHSRTDYLNNLENLFKNLNL

Nucleotide

• Length: 342 bp

>T37688 NZ_AP023393:c591891-591550 [Streptococcus dysgalactiae subsp. equisimilis]
ATGGCCTATAATGTACAAATTACCAAAAGTGCCGAGAGAGATCTAGACAGTATCTATCAGTTCTATCTAGATGAATTTTC
TGAACAAAGTGCTTTGAAAGTTATCAAAAGCCTTCAAGATGCTATCAGCTTTCTTTATGTTTCACCACTTGGCTACACCG
ACTTCGATTCTAAAATCAATCGAAAAATTTATCCACAAGGTAATCTAAGAATGATTCCTTCAAAGCAATACCTTATTTTT
TATCTTATCCGTGAAGAAAGGGTAGATGTTTTAAGAATTATTCATTCTAGAACAGATTATCTCAATAATTTAGAAAATCT
CTTTAAAAATCTAAACCTTTAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10869.33 Da
• Isoelectric Point: 4.3885

>AT37688 WP_003058067.1 NZ_AP023393:c592168-591881 [Streptococcus dysgalactiae subsp. equisimilis]
MNTLARDRQYNFRVNADMLNQAKEILEEKHMSLPDALNLFVEQVVVTKDLPIKTPEQVQAESFLNELISELDEGYQDVLK
GNTKPANEVFAKYGL

Nucleotide

• Length: 288 bp

>AT37688 NZ_AP023393:c592168-591881 [Streptococcus dysgalactiae subsp. equisimilis]
ATGAATACACTAGCAAGAGATCGCCAATATAATTTCCGTGTCAATGCGGATATGCTAAATCAGGCTAAGGAAATTTTGGA
GGAAAAACATATGTCTCTACCTGATGCTCTTAATTTATTTGTAGAGCAAGTGGTTGTCACTAAAGACCTCCCTATCAAAA
CACCTGAGCAAGTTCAAGCTGAATCTTTCTTAAATGAATTAATTTCAGAACTTGATGAAGGCTATCAAGATGTTCTAAAA
GGAAATACAAAACCAGCTAATGAGGTTTTTGCAAAATATGGCCTATAA