Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 284541..285153 Replicon chromosome
Accession NZ_AP023393
Organism Streptococcus dysgalactiae subsp. equisimilis strain 89

Toxin (Protein)


Gene name parE Uniprot ID Q8E1X3
Locus tag H7678_RS01540 Protein ID WP_000384858.1
Coordinates 284541..284876 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q8E1X2
Locus tag H7678_RS01545 Protein ID WP_000255538.1
Coordinates 284866..285153 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7678_RS01510 279561..279887 + 327 WP_000384270.1 replication initiator protein A -
H7678_RS01515 279891..280520 + 630 WP_000591148.1 hypothetical protein -
H7678_RS01520 280833..281708 + 876 WP_000770113.1 hypothetical protein -
H7678_RS01525 281744..282178 + 435 WP_001220479.1 hypothetical protein -
H7678_RS01530 282494..283714 + 1221 Protein_253 plasmid recombination protein -
H7678_RS01535 283766..284236 + 471 WP_000130119.1 hypothetical protein -
H7678_RS01540 284541..284876 - 336 WP_000384858.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H7678_RS01545 284866..285153 - 288 WP_000255538.1 hypothetical protein Antitoxin
H7678_RS01550 285558..286169 - 612 WP_171842254.1 tyrosine-type recombinase/integrase -
H7678_RS01555 286301..287164 - 864 WP_046177583.1 IS982 family transposase -
H7678_RS01560 287960..289898 + 1939 Protein_259 PTS sugar transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 286301..287164 863


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13264.04 Da        Isoelectric Point: 5.2388

>T37687 WP_000384858.1 NZ_AP023393:c284876-284541 [Streptococcus dysgalactiae subsp. equisimilis]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQHKMEQIISDIEKLEVFPEVGFDADEKYGSKISKYHSTRGYTLSKD
YIVLYHIEEEENRVVIDYLLPTRSDYMKLFK

Download         Length: 336 bp

>T37687 NZ_AP023393:c284876-284541 [Streptococcus dysgalactiae subsp. equisimilis]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGTTAAAGGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCGACATCAGGTCAGCACAAAATGGAGCAAATCATTAGTGACATAGAAAAACTCGAGGTTTTCCCTGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCAGTAAGTACCACAGCACTAGAGGTTATACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGAGGAAGAGAATAGGGTCGTTATTGATTACTTGCTTCCTACTCGAAGCGACTATAT
GAAATTGTTTAAATAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10921.47 Da        Isoelectric Point: 4.7271

>AT37687 WP_000255538.1 NZ_AP023393:c285153-284866 [Streptococcus dysgalactiae subsp. equisimilis]
MVTAEKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRSELGL

Download         Length: 288 bp

>AT37687 NZ_AP023393:c285153-284866 [Streptococcus dysgalactiae subsp. equisimilis]
ATGGTTACAGCAGAAAAAAATAGAGCTGTCACATTCCAAGCTAACAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAGAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTTCAAAATGTCGTTGTCACAAATGAGGTTGACTTATTGA
CGGAAGAGGAGCTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAAGATGTTCGTCAA
GGGAAATTTTATACCTCTGAAGAAGTGAGGTCTGAACTTGGACTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1EF10

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1EFF9

References