Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1060652..1061153 Replicon chromosome
Accession NZ_AP023392
Organism Streptococcus suis strain DAT300

Toxin (Protein)


Gene name relE Uniprot ID A0A0Z8GZU5
Locus tag H7679_RS05290 Protein ID WP_024397888.1
Coordinates 1060887..1061153 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A3R8T0W2
Locus tag H7679_RS05285 Protein ID WP_044675807.1
Coordinates 1060652..1060903 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7679_RS05260 1055980..1057146 + 1167 WP_105114958.1 carbamoyl phosphate synthase large subunit -
H7679_RS05265 1057286..1057426 + 141 WP_032497540.1 hypothetical protein -
H7679_RS05270 1057439..1057828 + 390 WP_105114957.1 NisI/SpaI family lantibiotic immunity lipoprotein -
H7679_RS05275 1057837..1058589 + 753 WP_105114956.1 ABC transporter ATP-binding protein -
H7679_RS05280 1058590..1060560 + 1971 WP_105114955.1 FtsX-like permease family protein -
H7679_RS05285 1060652..1060903 + 252 WP_044675807.1 hypothetical protein Antitoxin
H7679_RS05290 1060887..1061153 + 267 WP_024397888.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H7679_RS05295 1061192..1061860 + 669 WP_024385714.1 response regulator transcription factor -
H7679_RS05300 1061857..1062798 + 942 WP_044674994.1 sensor histidine kinase -
H7679_RS05305 1062874..1064382 + 1509 WP_105114954.1 phosphomannomutase/phosphoglucomutase -
H7679_RS05310 1064452..1065522 - 1071 WP_105114953.1 tyrosine recombinase XerS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-87)

Antitoxin

Protein of unknown function DUF6290

(1-75)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10378.05 Da        Isoelectric Point: 10.6122

>T37685 WP_024397888.1 NZ_AP023392:1060887-1061153 [Streptococcus suis]
MKTCYKLVPTSRFIKQLKKLDKFTQKQITNYLSSHVTDNPRQYGKALTANRSGQWRYRIGNYRVIVSIEDDKLIVTALEV
GHRKEVYK

Download         Length: 267 bp

>T37685 NZ_AP023392:1060887-1061153 [Streptococcus suis]
ATGAAGACCTGTTATAAACTCGTACCGACCAGTCGTTTTATTAAACAGTTGAAAAAGTTGGACAAATTTACCCAAAAACA
GATTACCAACTACCTGTCTAGTCATGTGACCGACAACCCTAGACAATACGGAAAAGCCTTGACTGCTAATCGTTCTGGCC
AATGGCGCTATCGTATCGGCAACTACAGGGTTATCGTCAGCATTGAAGATGATAAATTGATTGTAACAGCCCTTGAAGTC
GGGCATCGAAAAGAAGTATATAAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9309.59 Da        Isoelectric Point: 3.7666

>AT37685 WP_044675807.1 NZ_AP023392:1060652-1060903 [Streptococcus suis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADIALAEYEADLAKGIEPISWEEMLEELGLTDE
DLL

Download         Length: 252 bp

>AT37685 NZ_AP023392:1060652-1060903 [Streptococcus suis]
ATGGCAGCTATCACATTGAAAGTGTCTGAGCAGGACAAGCTTTTTATGCAGGCTATGGCAAAATTTGAAGGTGTGAGTTT
GTCAGAACTCATTCGGACTAAGACCCTTGAGGCTCTCGAAGATGAATACGACGCCCGTGTGGCAGATATCGCTCTGGCTG
AATACGAGGCAGACTTGGCGAAAGGCATTGAACCGATTAGCTGGGAGGAAATGTTGGAAGAGTTGGGGTTGACGGATGAA
GACCTGTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8GZU5

Antitoxin

Source ID Structure
AlphaFold DB A0A3R8T0W2

References