Detailed information of TA system TA037682

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1415539..1416022
• Replicon: chromosome
• Accession: NZ_AP023391
• Organism: Streptococcus suis strain DAT299

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: H7677_RS06895
• Protein ID: WP_184493199.1
• Coordinates: 1415539..1415799 (-)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A0Z8BIX7
• Locus tag: H7677_RS06900
• Protein ID: WP_012775256.1
• Coordinates: 1415801..1416022 (-)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H7677_RS06870	1410924..1412153	-	1230	WP_184493193.1	tetratricopeptide repeat protein	-
H7677_RS06875	1412143..1413309	-	1167	WP_024387231.1	AI-2E family transporter	-
H7677_RS06880	1413445..1414449	+	1005	WP_184493195.1	lactonase family protein	-
H7677_RS06885	1414513..1414698	+	186	WP_024381988.1	hypothetical protein	-
H7677_RS06890	1414731..1415372	-	642	WP_184493197.1	HAD family hydrolase	-
H7677_RS06895	1415539..1415799	-	261	WP_184493199.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
H7677_RS06900	1415801..1416022	-	222	WP_012775256.1	hypothetical protein	Antitoxin
H7677_RS06905	1416418..1417725	-	1308	WP_002935704.1	phosphopyruvate hydratase	-
H7677_RS06910	1417875..1418327	+	453	WP_044678816.1	DUF1694 domain-containing protein	-
H7677_RS06915	1418520..1419647	-	1128	WP_184493201.1	glycerate kinase	-
H7677_RS06920	1419755..1420405	+	651	WP_184493203.1	HAD family hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-86)

Antitoxin

• Protein of unknown function DUF6290 (1-71)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10256.75 Da
• Isoelectric Point: 9.6925

>T37682 WP_184493199.1 NZ_AP023391:c1415799-1415539 [Streptococcus suis]
MYHLEYSKKAQKQIKKLDRQVQRLLFAWIDKHLEGTDNPRANGKGLTGNHANEWRYRIGDYRLICDIQDDKLVILALEFG
HRKDVY

Nucleotide

• Length: 261 bp

>T37682 NZ_AP023391:c1415799-1415539 [Streptococcus suis]
ATGTATCATTTAGAGTATTCTAAAAAGGCTCAAAAGCAAATTAAGAAATTAGATAGGCAAGTTCAGAGGTTGTTGTTTGC
TTGGATTGATAAACACTTAGAAGGGACTGATAATCCACGCGCCAATGGTAAAGGTTTGACAGGCAATCATGCTAACGAGT
GGCGTTATCGTATCGGAGATTACCGACTGATTTGCGATATTCAAGATGATAAGTTGGTTATTTTAGCACTTGAGTTTGGA
CATCGTAAAGATGTCTATTGA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8566.55 Da
• Isoelectric Point: 4.4791

>AT37682 WP_012775256.1 NZ_AP023391:c1416022-1415801 [Streptococcus suis]
MSTVTIRLNQEEEVFFKSYAQLTGQSLSSLFKKALERDIEDEYDLKIYHQAYDEYKADPETISHADFKKELGL

Nucleotide

• Length: 222 bp

>AT37682 NZ_AP023391:c1416022-1415801 [Streptococcus suis]
ATGAGTACAGTGACAATCAGATTAAATCAAGAAGAAGAAGTATTCTTTAAAAGCTATGCACAATTAACAGGTCAAAGTCT
TTCTAGCCTTTTTAAGAAAGCTTTGGAGCGTGATATTGAAGATGAGTATGATTTAAAAATCTATCATCAAGCTTATGATG
AGTACAAAGCAGATCCAGAAACAATTAGTCATGCTGATTTTAAGAAAGAGCTAGGATTATAG

Structures

Antitoxin

• AlphaFold DB: A0A0Z8BIX7