37681

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1033736..1034231 Replicon chromosome
Accession NZ_AP023391
Organism Streptococcus suis strain DAT299

Toxin (Protein)


Gene name relE Uniprot ID A0A0Z8F7Q7
Locus tag H7677_RS05115 Protein ID WP_024401228.1
Coordinates 1033965..1034231 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A123SEG2
Locus tag H7677_RS05110 Protein ID WP_015646833.1
Coordinates 1033736..1033975 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7677_RS05080 1029136..1029273 + 138 WP_002935027.1 hypothetical protein -
H7677_RS05085 1029286..1030020 + 735 WP_184494354.1 beta-carotene 15,15'-monooxygenase -
H7677_RS05090 1030119..1030259 + 141 WP_002935023.1 hypothetical protein -
H7677_RS05095 1030272..1030661 + 390 WP_184494356.1 NisI/SpaI family lantibiotic immunity lipoprotein -
H7677_RS05100 1030670..1031422 + 753 WP_015646831.1 ABC transporter ATP-binding protein -
H7677_RS05105 1031423..1033393 + 1971 WP_184494358.1 FtsX-like permease family protein -
H7677_RS05110 1033736..1033975 + 240 WP_015646833.1 hypothetical protein Antitoxin
H7677_RS05115 1033965..1034231 + 267 WP_024401228.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H7677_RS05120 1034270..1034938 + 669 WP_044667738.1 response regulator transcription factor -
H7677_RS05125 1034935..1035876 + 942 WP_184494360.1 sensor histidine kinase -
H7677_RS05130 1035952..1037460 + 1509 WP_184494362.1 phosphomannomutase/phosphoglucomutase -
H7677_RS05135 1037523..1038593 - 1071 WP_184494364.1 tyrosine recombinase XerS -
H7677_RS05140 1038762..1039155 - 394 Protein_978 adenylyl-sulfate kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Protein of unknown function DUF6290

(1-75)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10259.98 Da        Isoelectric Point: 10.4518

>T37681 WP_024401228.1 NZ_AP023391:1033965-1034231 [Streptococcus suis]
MSYKVILSAKAQKQIRKMDKTAASLILRYLYKHIDGCDNPRQYGKALTANRSGQWRYRIGNYRVIVSIEDDKLIVTALEV
GHRKEIYK

Download         Length: 267 bp

>T37681 NZ_AP023391:1033965-1034231 [Streptococcus suis]
TTGAGTTATAAGGTTATTTTGTCTGCTAAGGCCCAAAAGCAAATTCGAAAGATGGATAAAACCGCTGCAAGTTTGATTTT
GCGCTATCTCTACAAGCATATTGACGGTTGCGACAACCCTAGACAATACGGAAAAGCCTTGACTGCTAATCGTTCTGGCC
AATGGCGCTATCGTATCGGCAATTACAGGGTTATCGTCAGTATTGAAGATGACAAATTGATTGTAACGGCCCTTGAAGTC
GGGCATCGGAAAGAAATATATAAATAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8879.09 Da        Isoelectric Point: 3.7832

>AT37681 WP_015646833.1 NZ_AP023391:1033736-1033975 [Streptococcus suis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADIAWAEYQEDLANGIEPITLEQMAEELGIEL

Download         Length: 240 bp

>AT37681 NZ_AP023391:1033736-1033975 [Streptococcus suis]
ATGGCAGCTATTACATTGAAAGTTTCTGAGCAGGACAAGCTCTTTATGCAGGCTATGGCAAAGTTTGAAGGTGTCAGTTT
GTCAGAACTCATTCGGACTAAAACCCTTGAAGCACTTGAAGATGAGTACGATGCGCGTGTGGCAGATATTGCTTGGGCAG
AATACCAAGAAGACTTGGCGAATGGAATTGAGCCGATAACATTAGAACAAATGGCTGAGGAGTTGGGCATTGAGTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8F7Q7

Antitoxin

Source ID Structure
AlphaFold DB A0A123SEG2

References