Detailed information of TA system TA037679

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 1512987..1513599
• Replicon: chromosome
• Accession: NZ_AP023390
• Organism: Streptococcus pyogenes strain KUN-0014944

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: H7676_RS07370
• Protein ID: WP_002994716.1
• Coordinates: 1513264..1513599 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q5X9X9
• Locus tag: H7676_RS07365
• Protein ID: WP_002988079.1
• Coordinates: 1512987..1513274 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H7676_RS07340	1508177..1509160	-	984	WP_031488719.1	tagatose-bisphosphate aldolase	-
H7676_RS07345	1509164..1510093	-	930	WP_031488720.1	tagatose-6-phosphate kinase	-
H7676_RS07350	1510141..1510656	-	516	WP_002991700.1	galactose-6-phosphate isomerase subunit LacB	-
H7676_RS07355	1510691..1511119	-	429	WP_014635709.1	galactose-6-phosphate isomerase subunit LacA	-
H7676_RS07360	1511564..1512337	+	774	WP_002982738.1	DeoR/GlpR family DNA-binding transcription regulator	-
H7676_RS07365	1512987..1513274	+	288	WP_002988079.1	DNA-damage-inducible protein J	Antitoxin
H7676_RS07370	1513264..1513599	+	336	WP_002994716.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
H7676_RS07375	1513751..1514221	+	471	WP_021733374.1	site-specific integrase	-
H7676_RS07380	1514184..1514732	+	549	WP_180372715.1	site-specific integrase	-
H7676_RS07385	1514864..1515256	-	393	WP_002982716.1	30S ribosomal protein S9	-
H7676_RS07390	1515277..1515723	-	447	WP_002982710.1	50S ribosomal protein L13	-
H7676_RS07395	1515941..1516147	-	207	WP_002982695.1	helix-turn-helix transcriptional regulator	-
H7676_RS07400	1516144..1516650	-	507	WP_002988070.1	hypothetical protein	-
H7676_RS07405	1516786..1517646	-	861	WP_011529009.1	DegV family protein	-
H7676_RS07410	1517743..1518261	-	519	WP_002982682.1	NYN domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-104)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13154.89 Da
• Isoelectric Point: 5.6157

>T37679 WP_002994716.1 NZ_AP023390:1513264-1513599 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQHKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTRSDYIKLFK

Nucleotide

• Length: 336 bp

>T37679 NZ_AP023390:1513264-1513599 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCATAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCTGATGAAAAATATGGTTCAAAAATCAGCCATTATCACAGCACTAAAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCGAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10934.56 Da
• Isoelectric Point: 5.2318

>AT37679 WP_002988079.1 NZ_AP023390:1512987-1513274 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT37679 NZ_AP023390:1512987-1513274 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Structures

Antitoxin

• AlphaFold DB: A0A4U7GX94