Detailed information of TA system TA037678

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 1617462..1618074
• Replicon: chromosome
• Accession: NZ_AP023389
• Organism: Streptococcus pyogenes strain KUN-0012590

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: H7675_RS08190
• Protein ID: WP_002994716.1
• Coordinates: 1617739..1618074 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q5X9X9
• Locus tag: H7675_RS08185
• Protein ID: WP_002988079.1
• Coordinates: 1617462..1617749 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H7675_RS08160	1612641..1613624	-	984	WP_111711469.1	tagatose-bisphosphate aldolase	-
H7675_RS08165	1613628..1614557	-	930	WP_111711470.1	tagatose-6-phosphate kinase	-
H7675_RS08170	1614605..1615120	-	516	WP_002991700.1	galactose-6-phosphate isomerase subunit LacB	-
H7675_RS08175	1615155..1615583	-	429	WP_014635709.1	galactose-6-phosphate isomerase subunit LacA	-
H7675_RS08180	1616028..1616801	+	774	WP_002982738.1	DeoR/GlpR family DNA-binding transcription regulator	-
H7675_RS08185	1617462..1617749	+	288	WP_002988079.1	DNA-damage-inducible protein J	Antitoxin
H7675_RS08190	1617739..1618074	+	336	WP_002994716.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
H7675_RS08195	1618226..1618696	+	471	WP_021733374.1	site-specific integrase	-
H7675_RS08200	1618659..1619207	+	549	WP_180372715.1	site-specific integrase	-
H7675_RS08205	1619339..1619731	-	393	WP_002982716.1	30S ribosomal protein S9	-
H7675_RS08210	1619752..1620198	-	447	WP_002982710.1	50S ribosomal protein L13	-
H7675_RS08215	1620416..1620622	-	207	WP_002982695.1	helix-turn-helix transcriptional regulator	-
H7675_RS08220	1620619..1621125	-	507	WP_002988070.1	hypothetical protein	-
H7675_RS08225	1621261..1622121	-	861	WP_011529009.1	DegV family protein	-
H7675_RS08230	1622218..1622736	-	519	WP_002982682.1	NYN domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1593555..1621125	27570

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-104)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13154.89 Da
• Isoelectric Point: 5.6157

>T37678 WP_002994716.1 NZ_AP023389:1617739-1618074 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQHKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTRSDYIKLFK

Nucleotide

• Length: 336 bp

>T37678 NZ_AP023389:1617739-1618074 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCATAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCTGATGAAAAATATGGTTCAAAAATCAGCCATTATCACAGCACTAAAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCGAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10934.56 Da
• Isoelectric Point: 5.2318

>AT37678 WP_002988079.1 NZ_AP023389:1617462-1617749 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT37678 NZ_AP023389:1617462-1617749 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Structures

Antitoxin

• AlphaFold DB: A0A4U7GX94