Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1801647..1802133 Replicon chromosome
Accession NZ_AP023388
Organism Streptococcus pyogenes strain NIH35

Toxin (Protein)


Gene name relE Uniprot ID Q48QR0
Locus tag H7674_RS08810 Protein ID WP_014407961.1
Coordinates 1801647..1801916 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A660A1J7
Locus tag H7674_RS08815 Protein ID WP_014407962.1
Coordinates 1801906..1802133 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7674_RS08795 1797142..1798215 + 1074 WP_011285298.1 DUF4097 family beta strand repeat protein -
H7674_RS08800 1798332..1800605 - 2274 WP_021340697.1 YhgE/Pip domain-containing protein -
H7674_RS08805 1800740..1801273 + 534 WP_010922785.1 TetR/AcrR family transcriptional regulator -
H7674_RS08810 1801647..1801916 - 270 WP_014407961.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H7674_RS08815 1801906..1802133 - 228 WP_014407962.1 hypothetical protein Antitoxin
H7674_RS08820 1802286..1802657 - 372 WP_011285302.1 DUF1492 domain-containing protein -
H7674_RS08825 1802647..1802994 - 348 WP_011285303.1 DUF1492 domain-containing protein -
H7674_RS08830 1803275..1803520 - 246 WP_011285304.1 hypothetical protein -
H7674_RS08835 1803495..1803770 - 276 WP_014407964.1 hypothetical protein -
H7674_RS08840 1803760..1804098 - 339 WP_030126557.1 replication protein -
H7674_RS08845 1804140..1804406 - 267 WP_011285307.1 hypothetical protein -
H7674_RS08850 1804403..1805191 - 789 WP_011285308.1 hypothetical protein -
H7674_RS08855 1805282..1805440 - 159 WP_011285309.1 hypothetical protein -
H7674_RS08860 1805454..1805699 - 246 WP_011285310.1 hypothetical protein -
H7674_RS08865 1805695..1806021 - 327 Protein_1689 hypothetical protein -
H7674_RS08870 1806023..1806196 - 174 WP_011285312.1 hypothetical protein -
H7674_RS08875 1806202..1806375 - 174 WP_000694580.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10497.50 Da        Isoelectric Point: 10.5027

>T37677 WP_014407961.1 NZ_AP023388:c1801916-1801647 [Streptococcus pyogenes]
MTYKLVVSDEVKKQLKKMDKHVGLMLAKDMKKRLDGLNNPRQFGKALTGQYKGLWRYRVGNYRVICDIVDNEMIILALEV
GHRKEIYKR

Download         Length: 270 bp

>T37677 NZ_AP023388:c1801916-1801647 [Streptococcus pyogenes]
ATGACTTATAAGCTAGTGGTGAGTGATGAAGTCAAGAAGCAACTCAAAAAGATGGATAAACATGTAGGGCTTATGTTAGC
CAAAGACATGAAGAAACGACTTGACGGGTTAAATAATCCTAGACAATTTGGAAAAGCCCTCACAGGTCAATATAAAGGAC
TTTGGCGCTATCGTGTTGGTAATTATCGGGTGATTTGTGACATTGTGGATAATGAAATGATTATCCTTGCTTTGGAAGTT
GGACACAGGAAAGAGATATACAAGCGCTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8641.63 Da        Isoelectric Point: 3.9607

>AT37677 WP_014407962.1 NZ_AP023388:c1802133-1801906 [Streptococcus pyogenes]
MAMVSLRLNSAEEELFRSYATHTGKTLSELFKTALAQQIEDQLDYETGIQALKRFEENPITYSIDDLIEELENDL

Download         Length: 228 bp

>AT37677 NZ_AP023388:c1802133-1801906 [Streptococcus pyogenes]
ATGGCAATGGTATCATTAAGACTGAACAGCGCAGAGGAAGAACTTTTCAGAAGCTACGCTACACACACAGGCAAAACATT
ATCTGAATTATTCAAGACAGCACTAGCACAACAAATTGAAGATCAATTGGACTATGAAACAGGTATTCAAGCTTTAAAAC
GCTTTGAAGAAAATCCCATAACTTATTCTATCGATGATTTAATTGAGGAGTTGGAAAATGACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A660A202

Antitoxin

Source ID Structure
AlphaFold DB A0A660A1J7

References