Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 2624102..2624679 Replicon chromosome
Accession NZ_AP023366
Organism Effusibacillus sp. skT53

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag skT53_RS14120 Protein ID WP_200758117.1
Coordinates 2624102..2624452 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag skT53_RS14125 Protein ID WP_200758125.1
Coordinates 2624446..2624679 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
skT53_RS14095 2620088..2622421 + 2334 WP_200758109.1 O-antigen ligase family protein -
skT53_RS14100 2622485..2622754 - 270 WP_200760995.1 retropepsin-like domain-containing protein -
skT53_RS14105 2622854..2623108 - 255 WP_200758111.1 hypothetical protein -
skT53_RS14110 2623376..2623765 + 390 WP_200758113.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
skT53_RS14115 2623762..2624061 + 300 WP_200758115.1 type II toxin-antitoxin system RelE/ParE family toxin -
skT53_RS14120 2624102..2624452 - 351 WP_200758117.1 endoribonuclease MazF Toxin
skT53_RS14125 2624446..2624679 - 234 WP_200758125.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
skT53_RS14130 2624734..2625354 - 621 WP_200758131.1 phosphatase PAP2 family protein -
skT53_RS14135 2625360..2626670 - 1311 WP_200758139.1 VTT domain-containing protein -
skT53_RS14140 2626688..2627260 - 573 WP_200758141.1 methyltransferase -
skT53_RS14145 2627446..2627742 - 297 WP_200758143.1 hypothetical protein -
skT53_RS14150 2627903..2628985 - 1083 WP_200758145.1 YheC/YheD family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(12-111)

Antitoxin

Antitoxin PemI-like

(1-77)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12797.01 Da        Isoelectric Point: 9.1235

>T37675 WP_200758117.1 NZ_AP023366:c2624452-2624102 [Effusibacillus sp. skT53]
MVSSTPHAYIPERGDIIWLQFNPQAGHEQAGRRPALVVSPIGYNQKVGLAIVCPITNQIKGYPFEVILPTDLPVTGGILV
DQIKNLNWRVRQAQFVCKVPPETITDALLKLGTLLK

Download         Length: 351 bp

>T37675 NZ_AP023366:c2624452-2624102 [Effusibacillus sp. skT53]
ATGGTAAGCAGTACACCACATGCGTATATACCAGAGCGGGGAGATATCATTTGGCTTCAGTTTAACCCCCAAGCCGGGCA
TGAACAGGCTGGAAGGCGACCGGCTTTGGTGGTTTCCCCCATAGGATATAACCAAAAAGTCGGACTAGCCATTGTCTGCC
CAATAACGAATCAAATAAAAGGCTATCCTTTTGAAGTGATCCTACCCACTGACTTGCCAGTCACCGGTGGTATCCTTGTT
GACCAAATTAAAAATTTGAATTGGAGAGTAAGACAAGCACAATTTGTTTGTAAAGTACCTCCTGAAACGATTACCGATGC
ACTCCTCAAATTAGGTACACTCCTAAAATAG

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8805.95 Da        Isoelectric Point: 4.2096

>AT37675 WP_200758125.1 NZ_AP023366:c2624679-2624446 [Effusibacillus sp. skT53]
MQTYVTKWGNSLGIRIPASMAEQAHIENGTPIEIQIKDDMIIIRRQTYTLEELLAQITPENLHDEVNTSDPIGNEIW

Download         Length: 234 bp

>AT37675 NZ_AP023366:c2624679-2624446 [Effusibacillus sp. skT53]
ATGCAAACCTATGTAACAAAATGGGGTAATAGCTTAGGGATTCGCATCCCTGCATCGATGGCGGAACAGGCTCACATCGA
GAACGGGACACCCATAGAAATTCAAATCAAAGATGACATGATCATTATTCGTCGCCAAACCTATACGTTAGAAGAACTTT
TGGCGCAAATTACCCCTGAAAATTTGCATGACGAAGTAAATACATCAGATCCGATAGGTAACGAGATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References