Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemK-mazE/MazF(toxin)
Location 2111376..2112005 Replicon chromosome
Accession NZ_AP023366
Organism Effusibacillus sp. skT53

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag skT53_RS11335 Protein ID WP_200756972.1
Coordinates 2111376..2111726 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag skT53_RS11340 Protein ID WP_200756973.1
Coordinates 2111730..2112005 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
skT53_RS11315 2106515..2107906 + 1392 WP_200756967.1 hypothetical protein -
skT53_RS11320 2107966..2109225 - 1260 WP_200756968.1 L-lactate permease -
skT53_RS11325 2109499..2110053 + 555 WP_200756969.1 XRE family transcriptional regulator -
skT53_RS11330 2110060..2111274 - 1215 WP_200756970.1 MFS transporter -
skT53_RS11335 2111376..2111726 - 351 WP_200756972.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
skT53_RS11340 2111730..2112005 - 276 WP_200756973.1 ribbon-helix-helix domain-containing protein Antitoxin
skT53_RS11345 2112095..2113216 - 1122 WP_200756975.1 alanine racemase -
skT53_RS11350 2113377..2114384 - 1008 WP_200756977.1 DUF4367 domain-containing protein -
skT53_RS11355 2114531..2115307 + 777 WP_200760961.1 2,4-dienoyl-CoA reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(4-44)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12881.92 Da        Isoelectric Point: 5.1663

>T37674 WP_200756972.1 NZ_AP023366:c2111726-2111376 [Effusibacillus sp. skT53]
MSVKRGDVFFAELSPVVGSEQGGFRPVLILQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIKADKDGLERDSVILLEQI
RTIDKQRLTDKITHLDDELMSRVNDALLISLGLIEF

Download         Length: 351 bp

>T37674 NZ_AP023366:c2111726-2111376 [Effusibacillus sp. skT53]
TTGAGTGTCAAGCGTGGGGATGTTTTCTTTGCTGAATTATCACCCGTGGTCGGTTCCGAACAGGGTGGGTTCCGCCCCGT
GCTCATTCTCCAAAATGACATCGGCAATCGATTCAGTCCTACTGTAATTGTGGCTGCTATTACCGCCCAAATTCAAAAAG
CGAAACTCCCTACCCATGTAGAGATCAAAGCTGATAAAGACGGACTGGAAAGAGATTCGGTTATTCTTCTGGAACAGATT
CGCACTATTGACAAACAGCGGTTAACAGATAAAATTACGCATCTGGACGATGAATTGATGTCTCGTGTGAATGATGCATT
ATTGATTTCGCTTGGATTGATTGAATTTTAA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10700.45 Da        Isoelectric Point: 8.5544

>AT37674 WP_200756973.1 NZ_AP023366:c2112005-2111730 [Effusibacillus sp. skT53]
MLSNKKRIMVSIPNHLLQEMDGIVEQEKSNRSELIRQAMRLYLNERKKRFIRETMQRGYMEMAKINLNIASEAFLAEEEA
ETTLERLVSGV

Download         Length: 276 bp

>AT37674 NZ_AP023366:c2112005-2111730 [Effusibacillus sp. skT53]
ATGTTGTCAAATAAAAAAAGGATAATGGTCAGTATTCCGAATCATCTTCTGCAGGAAATGGACGGTATCGTGGAGCAGGA
GAAATCAAACCGCAGCGAACTGATTCGCCAAGCAATGCGTTTGTATTTAAATGAGCGGAAGAAACGATTCATCCGAGAAA
CCATGCAGCGCGGTTATATGGAAATGGCCAAAATCAATTTAAACATTGCCTCGGAGGCGTTCCTGGCGGAAGAAGAAGCG
GAGACAACACTAGAACGGCTTGTAAGCGGGGTGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References