Detailed information of TA system TA037673

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YoeB-YefM
• Location: 204617..205116
• Replicon: plasmid pTY81_01
• Accession: NZ_AP023363
• Organism: Mycolicibacterium sp. TY81

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A1S1LJN6
• Locus tag: KI240_RS30610
• Protein ID: WP_070947462.1
• Coordinates: 204862..205116 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: KI240_RS30605
• Protein ID: WP_212815057.1
• Coordinates: 204617..204865 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KI240_RS30580 (MTY81_62440)	200178..201362	+	1185	WP_212815052.1	hypothetical protein	-
KI240_RS30585	201396..201683	+	288	WP_212815053.1	hypothetical protein	-
KI240_RS30590 (MTY81_62450)	201680..203296	+	1617	WP_212815054.1	hypothetical protein	-
KI240_RS30595 (MTY81_62460)	203345..203500	+	156	WP_212815055.1	hypothetical protein	-
KI240_RS30600 (MTY81_62480)	204137..204526	-	390	WP_212815056.1	hypothetical protein	-
KI240_RS30605 (MTY81_62490)	204617..204865	+	249	WP_212815057.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
KI240_RS30610 (MTY81_62500)	204862..205116	+	255	WP_070947462.1	Txe/YoeB family addiction module toxin	Toxin
KI240_RS30615 (MTY81_62510)	205199..205669	-	471	WP_070947461.1	hypothetical protein	-
KI240_RS30620 (MTY81_62520)	205672..205950	-	279	WP_070947460.1	hypothetical protein	-
KI240_RS30625 (MTY81_62530)	205947..206822	-	876	WP_070947459.1	ParA family protein	-
KI240_RS30630 (MTY81_62540)	206966..208621	-	1656	WP_244873003.1	chromosome partitioning protein ParB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..277627	277627

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (1-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-71)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9561.92 Da
• Isoelectric Point: 8.9186

>T37673 WP_070947462.1 NZ_AP023363:204862-205116 [Mycolicibacterium sp. TY81]
MNIVFSPQAWEDYQYWRSAQAPLLGRINRLIVDACRSPGDGIGRPEPLKYGIAGAWSRRITAEHRLVYRVVGDDLQLVAI
GHHY

Nucleotide

• Length: 255 bp

>T37673 NZ_AP023363:204862-205116 [Mycolicibacterium sp. TY81]
ATGAACATCGTCTTTTCGCCCCAAGCGTGGGAGGACTACCAGTACTGGCGCTCCGCCCAGGCGCCTCTGCTGGGCCGGAT
CAATCGGCTCATTGTCGACGCGTGCCGGTCCCCCGGCGACGGGATCGGGAGGCCAGAGCCGCTCAAGTACGGCATCGCTG
GGGCGTGGTCGCGGCGGATAACTGCCGAGCACCGCTTGGTGTACCGAGTGGTGGGCGATGACCTTCAACTCGTTGCGATC
GGGCATCACTACTGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 8903.08 Da
• Isoelectric Point: 4.5203

>AT37673 WP_212815057.1 NZ_AP023363:204617-204865 [Mycolicibacterium sp. TY81]
MAITASEARKRLFPLIEQVNNDRMPVEITSKGGDAVLMAADEWAAWQETAYLFQSPENARRLLDAAAALDRGLGVRGGLS
EA

Nucleotide

• Length: 249 bp

>AT37673 NZ_AP023363:204617-204865 [Mycolicibacterium sp. TY81]
ATGGCCATTACGGCGAGCGAAGCGCGCAAGCGCCTGTTCCCGCTCATCGAGCAAGTCAACAACGATCGCATGCCCGTAGA
AATCACTTCCAAAGGTGGCGACGCGGTGCTGATGGCGGCCGACGAGTGGGCGGCGTGGCAGGAGACGGCGTACCTGTTTC
AGTCACCGGAGAACGCTCGGCGGCTCCTCGACGCGGCCGCTGCTCTTGATCGCGGTTTGGGCGTGCGGGGCGGACTTTCC
GAGGCATGA

Structures

Toxin

• AlphaFold DB: A0A1S1LJN6