Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 5872156..5872808 Replicon chromosome
Accession NZ_AP023362
Organism Mycolicibacterium sp. TY81

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag KI240_RS28030 Protein ID WP_212813148.1
Coordinates 5872371..5872808 (+) Length 146 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID -
Locus tag KI240_RS28025 Protein ID WP_212813150.1
Coordinates 5872156..5872368 (+) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KI240_RS28010 (MTY81_57240) 5867775..5868509 + 735 WP_020098935.1 enoyl-CoA hydratase -
KI240_RS28015 (MTY81_57250) 5868509..5869624 + 1116 WP_212813154.1 MBL fold metallo-hydrolase -
KI240_RS28020 (MTY81_57260) 5869698..5872106 + 2409 WP_212813152.1 HAD-IC family P-type ATPase -
KI240_RS28025 (MTY81_57270) 5872156..5872368 + 213 WP_212813150.1 antitoxin Antitoxin
KI240_RS28030 (MTY81_57280) 5872371..5872808 + 438 WP_212813148.1 SRPBCC family protein Toxin
KI240_RS28035 (MTY81_57290) 5872954..5873724 + 771 WP_212813140.1 VOC family protein -
KI240_RS28040 (MTY81_57300) 5873832..5874092 + 261 WP_212813138.1 hypothetical protein -
KI240_RS28045 (MTY81_57310) 5874100..5875779 - 1680 WP_212813136.1 NAD-binding protein -
KI240_RS28050 (MTY81_57320) 5875785..5876225 - 441 WP_212813126.1 cupin domain-containing protein -
KI240_RS28055 (MTY81_57330) 5876288..5876698 + 411 WP_212813124.1 hypothetical protein -
KI240_RS28060 (MTY81_57340) 5876695..5877285 + 591 WP_212813122.1 GNAT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-142)

Antitoxin

Antitoxin Rv0909/MT0933

(4-52)


Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15550.03 Da        Isoelectric Point: 9.5944

>T37672 WP_212813148.1 NZ_AP023362:5872371-5872808 [Mycolicibacterium sp. TY81]
MAKLASSIEVPLSPEKAWEAASDLSRYDDWLSIHRMWRSPLPETLGKGTQISSVVEVKGMLNRVDWTIVHYNPPGSLTLN
GVGKGGVRVKLMAKITPAGDGSNVAFDIHLGGPALFGPIGMVVAAALRSDIHQSLEKFKALFASV

Download         Length: 438 bp

>T37672 NZ_AP023362:5872371-5872808 [Mycolicibacterium sp. TY81]
ATGGCAAAACTCGCAAGTTCCATCGAAGTACCGCTGTCGCCCGAAAAGGCCTGGGAGGCAGCGTCGGACCTCTCCCGGTA
TGACGACTGGCTGTCCATCCACCGGATGTGGCGCAGCCCGTTGCCCGAGACCCTGGGGAAGGGCACGCAGATCTCGTCCG
TCGTCGAGGTCAAGGGCATGCTGAACCGGGTCGACTGGACCATCGTGCATTACAACCCGCCGGGATCGTTGACCCTCAAC
GGCGTCGGCAAGGGTGGGGTCCGGGTCAAGTTGATGGCCAAGATCACGCCGGCCGGCGACGGTTCGAACGTGGCGTTCGA
CATCCACCTCGGTGGCCCGGCCCTGTTCGGACCCATCGGTATGGTGGTGGCAGCTGCGCTGCGGTCCGACATCCACCAGT
CACTGGAGAAGTTCAAGGCGCTGTTCGCGTCGGTGTAG

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7258.01 Da        Isoelectric Point: 4.2092

>AT37672 WP_212813150.1 NZ_AP023362:5872156-5872368 [Mycolicibacterium sp. TY81]
MGFLDKVKDLAAQNADKVEAAIEKVGDIVDEKTEGKFKGAVDSAQEAAKKAVAGDQPAAEAPAEGTQEQQ

Download         Length: 213 bp

>AT37672 NZ_AP023362:5872156-5872368 [Mycolicibacterium sp. TY81]
ATGGGATTTCTGGACAAGGTGAAGGACCTGGCGGCGCAGAACGCCGACAAGGTCGAGGCCGCTATCGAGAAGGTCGGCGA
CATCGTCGACGAGAAGACCGAAGGCAAGTTCAAGGGCGCTGTCGACAGCGCCCAGGAAGCGGCGAAGAAGGCCGTCGCAG
GAGACCAGCCTGCTGCTGAGGCTCCTGCCGAGGGGACGCAAGAACAGCAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References