Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 4353776..4354439 Replicon chromosome
Accession NZ_AP023362
Organism Mycolicibacterium sp. TY81

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KI240_RS20985 Protein ID WP_212807252.1
Coordinates 4354011..4354439 (+) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag KI240_RS20980 Protein ID WP_212814558.1
Coordinates 4353776..4354024 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KI240_RS20960 (MTY81_42880) 4349131..4349937 + 807 WP_061006885.1 hypothetical protein -
KI240_RS20965 (MTY81_42890) 4349999..4350214 - 216 WP_212807250.1 hypothetical protein -
KI240_RS20970 (MTY81_42900) 4350689..4352116 + 1428 WP_083612599.1 IS1182 family transposase -
KI240_RS20975 (MTY81_42910) 4352277..4353668 - 1392 WP_212807251.1 MFS transporter -
KI240_RS20980 (MTY81_42920) 4353776..4354024 + 249 WP_212814558.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
KI240_RS20985 (MTY81_42930) 4354011..4354439 + 429 WP_212807252.1 type II toxin-antitoxin system VapC family toxin Toxin
KI240_RS20990 (MTY81_42940) 4354442..4355011 - 570 WP_064859702.1 flavin reductase family protein -
KI240_RS20995 (MTY81_42950) 4355023..4355925 - 903 WP_212807253.1 VOC family protein -
KI240_RS21000 (MTY81_42960) 4355941..4357131 - 1191 WP_212807254.1 flavin-dependent monooxygenase -
KI240_RS21005 (MTY81_42970) 4357287..4358357 + 1071 WP_212807255.1 ferredoxin--NADP reductase -
KI240_RS21010 (MTY81_42980) 4358380..4358955 + 576 WP_212807256.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-41)


Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15687.93 Da        Isoelectric Point: 7.3846

>T37671 WP_212807252.1 NZ_AP023362:4354011-4354439 [Mycolicibacterium sp. TY81]
MLLVDVNIWVYAIRSDSAQHGTYREWVEEALTGSEPVGVSELVLSGVMRLITNHRIFSQPSSTAEALDACRAIRSAPSAI
SLRPGPRHWSIFEKLCTTVGAKANVVPDAYHAALAIEHGATWVTTDRAFARFPGLKWRLPFE

Download         Length: 429 bp

>T37671 NZ_AP023362:4354011-4354439 [Mycolicibacterium sp. TY81]
ATGCTCCTCGTTGACGTCAACATCTGGGTCTATGCCATCCGCAGCGACAGTGCCCAGCACGGCACCTATCGAGAATGGGT
CGAAGAAGCGCTCACCGGCTCCGAACCAGTAGGCGTCAGCGAATTGGTGCTTTCCGGCGTCATGCGACTGATCACCAACC
ACCGGATTTTCTCGCAACCAAGCTCGACGGCAGAAGCTCTCGACGCATGCCGCGCGATCCGCTCAGCACCGTCGGCGATA
TCGCTACGGCCCGGACCCCGTCATTGGTCAATATTCGAAAAACTGTGCACGACCGTCGGCGCCAAGGCCAATGTCGTCCC
GGATGCCTACCACGCGGCGCTCGCGATCGAACACGGCGCCACATGGGTCACCACGGACCGGGCCTTCGCCCGCTTTCCAG
GTCTGAAGTGGCGCCTACCTTTTGAGTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8613.67 Da        Isoelectric Point: 5.0069

>AT37671 WP_212814558.1 NZ_AP023362:4353776-4354024 [Mycolicibacterium sp. TY81]
MRTTVNIDDHLLEEAKVLAARTSRSLGSVVEDGLRALLHRNNPGTSVGTFVLPTHGIGGLAPGVDLEDKDALAELTGDNA
PR

Download         Length: 249 bp

>AT37671 NZ_AP023362:4353776-4354024 [Mycolicibacterium sp. TY81]
ATGCGCACCACCGTCAACATCGACGATCACCTACTGGAAGAGGCCAAGGTGCTCGCGGCCAGGACATCCCGAAGCCTGGG
CTCGGTGGTCGAGGACGGACTTCGGGCATTGCTGCACCGAAACAACCCCGGCACGAGCGTCGGCACATTCGTGCTTCCAA
CCCATGGGATCGGCGGCCTTGCCCCCGGGGTCGATCTGGAAGACAAAGACGCCCTCGCCGAACTGACCGGCGACAATGCT
CCTCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References