37669

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 2281215..2282188 Replicon chromosome
Accession NZ_AP023362
Organism Mycolicibacterium sp. TY81

Toxin (Protein)


Gene name pezT Uniprot ID -
Locus tag KI240_RS10885 Protein ID WP_212811428.1
Coordinates 2281613..2282188 (+) Length 192 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID -
Locus tag KI240_RS10880 Protein ID WP_212811429.1
Coordinates 2281215..2281616 (+) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KI240_RS10850 (MTY81_22280) 2276484..2276774 - 291 WP_005148657.1 hypothetical protein -
KI240_RS10855 (MTY81_22290) 2276807..2277448 - 642 WP_005148656.1 organomercurial lyase MerB -
KI240_RS10860 (MTY81_22300) 2277475..2278878 - 1404 WP_005148655.1 mercury(II) reductase -
KI240_RS10865 (MTY81_22310) 2278935..2279324 + 390 WP_005148625.1 heavy metal-responsive transcriptional regulator -
KI240_RS10870 (MTY81_22320) 2279463..2280104 + 642 WP_079481877.1 cadmium resistance transporter -
KI240_RS10875 2280959..2281105 - 147 WP_212811430.1 hypothetical protein -
KI240_RS10880 (MTY81_22340) 2281215..2281616 + 402 WP_212811429.1 hypothetical protein Antitoxin
KI240_RS10885 (MTY81_22350) 2281613..2282188 + 576 WP_212811428.1 zeta toxin family protein Toxin
KI240_RS10890 (MTY81_22370) 2282700..2283251 + 552 WP_135356156.1 YaeQ family protein -
KI240_RS10895 (MTY81_22380) 2283365..2283916 + 552 WP_212811427.1 DapH/DapD/GlmU-related protein -
KI240_RS10900 (MTY81_22400) 2284660..2284971 + 312 WP_212811426.1 NIPSNAP family protein -
KI240_RS10905 (MTY81_22410) 2285007..2285585 + 579 WP_212811425.1 TetR/AcrR family transcriptional regulator -
KI240_RS10910 (MTY81_22420) 2285666..2286457 + 792 WP_061010194.1 SDR family NAD(P)-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(4-142)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(6-106)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 20950.93 Da        Isoelectric Point: 9.3920

>T37669 WP_212811428.1 NZ_AP023362:2281613-2282188 [Mycolicibacterium sp. TY81]
VKRLDLVVGSNGAGKSTFVELTLAPLLPSSVFVNADEIAKQRWPTDALGHAYEAARIAAATREALIEQGRSFIAETVFSH
PSKLELIDAARHAGYVVVLHIVLIPENLAVHRVRYRVAAGGHDVPEEKIRERYRRLWTLVAAAIVRVDSAAVYDNSAASG
PQIVAQMSGGLSVDTPRWPSWTPEQLRSRWP

Download         Length: 576 bp

>T37669 NZ_AP023362:2281613-2282188 [Mycolicibacterium sp. TY81]
GTGAAACGCCTGGACCTCGTCGTCGGCTCGAACGGTGCCGGAAAATCGACGTTCGTCGAACTCACGCTGGCTCCGCTGCT
ACCGAGCAGCGTGTTCGTCAACGCGGATGAGATCGCCAAACAGCGCTGGCCTACCGACGCTTTGGGCCACGCCTACGAGG
CCGCGCGGATCGCCGCGGCGACGCGGGAAGCGTTGATCGAGCAGGGGCGTTCATTCATCGCCGAGACCGTGTTCTCGCAC
CCCTCCAAGCTGGAGCTGATCGATGCGGCCCGTCATGCGGGGTACGTCGTGGTGTTGCACATTGTGCTGATCCCGGAGAA
CTTGGCCGTTCACCGCGTCCGCTACCGGGTTGCCGCCGGTGGCCACGATGTGCCCGAGGAGAAGATCCGGGAACGGTATC
GCCGGCTGTGGACATTGGTGGCTGCAGCGATCGTTCGCGTCGACAGCGCAGCGGTTTACGACAATTCCGCGGCCAGTGGA
CCGCAGATCGTGGCGCAGATGAGTGGCGGACTGAGCGTCGACACGCCCCGATGGCCGTCGTGGACTCCGGAACAGCTGCG
TAGTCGCTGGCCGTAG

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14192.69 Da        Isoelectric Point: 5.2297

>AT37669 WP_212811429.1 NZ_AP023362:2281215-2281616 [Mycolicibacterium sp. TY81]
MSEVADRVTRVSADLFEAAAAEGARQSRSAKQQLDHWARVGRAVSTQHTASRRRVEAALAGQIDIAVLNTEEGVVFNAEV
SAAIEESLARTDYGAVLASRGITTVALDEDGQIVEHRPDGTESVVGAVHSLRR

Download         Length: 402 bp

>AT37669 NZ_AP023362:2281215-2281616 [Mycolicibacterium sp. TY81]
ATGTCCGAAGTCGCCGATCGGGTCACCCGGGTGTCCGCTGACCTGTTCGAGGCCGCGGCCGCCGAGGGTGCCCGGCAGAG
TCGCTCCGCCAAGCAGCAACTCGACCATTGGGCGCGGGTGGGCCGCGCTGTATCGACCCAGCACACCGCTTCACGACGCA
GGGTGGAGGCTGCCCTCGCCGGTCAGATCGACATCGCCGTTCTCAACACCGAAGAAGGCGTGGTGTTCAATGCCGAGGTT
TCCGCGGCGATCGAGGAGAGTCTGGCCCGCACCGATTACGGTGCCGTGCTCGCCTCTCGTGGGATCACCACGGTGGCATT
GGATGAGGACGGCCAGATCGTCGAGCATCGCCCGGACGGCACCGAGTCCGTGGTTGGTGCGGTGCACTCGCTGCGTCGGT
GA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References