Detailed information of TA system TA037668

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 1450328..1450929
• Replicon: chromosome
• Accession: NZ_AP023362
• Organism: Mycolicibacterium sp. TY81

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: KI240_RS06965
• Protein ID: WP_212811942.1
• Coordinates: 1450328..1450729 (-)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: KI240_RS06970
• Protein ID: WP_133425925.1
• Coordinates: 1450726..1450929 (-)
• Length: 68 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KI240_RS06950 (MTY81_14340)	1445334..1445945	+	612	WP_234785328.1	DUF4194 domain-containing protein	-
KI240_RS06955 (MTY81_14350)	1445938..1449216	+	3279	WP_212811944.1	ATP-binding protein	-
KI240_RS06960 (MTY81_14360)	1449209..1450345	+	1137	WP_212811943.1	DUF3322 domain-containing protein	-
KI240_RS06965 (MTY81_14370)	1450328..1450729	-	402	WP_212811942.1	PIN domain nuclease	Toxin
KI240_RS06970 (MTY81_14380)	1450726..1450929	-	204	WP_133425925.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
KI240_RS06975 (MTY81_14390)	1451543..1454875	-	3333	WP_205848809.1	Swt1 family HEPN domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-120)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (3-41)

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14802.97 Da
• Isoelectric Point: 6.0803

>T37668 WP_212811942.1 NZ_AP023362:c1450729-1450328 [Mycolicibacterium sp. TY81]
MILVDTSAWIEFLRNTGSGVCVRVDELLAEPIAICAPVQMEILAGARNDRHLKDLRGLLARAQTLPTSPTDYEDAATIYR
VCRRRGETVRKVIDCLIAAHAIREQIPILHSDSDFDAIARHTSLQLDTSPRPD

Nucleotide

• Length: 402 bp

>T37668 NZ_AP023362:c1450729-1450328 [Mycolicibacterium sp. TY81]
ATGATCCTCGTTGACACGTCAGCCTGGATCGAGTTTCTAAGGAACACCGGGAGCGGTGTGTGCGTGCGAGTCGACGAGCT
ACTCGCCGAGCCGATCGCGATCTGCGCTCCCGTCCAGATGGAAATCCTCGCCGGGGCCCGAAACGACCGCCACCTCAAGG
ATCTTCGTGGCCTGTTGGCACGCGCACAAACTCTACCGACATCCCCCACTGACTATGAAGACGCCGCAACCATTTACCGC
GTCTGTCGGCGTCGCGGTGAAACCGTACGCAAAGTGATCGACTGCCTCATCGCCGCGCATGCCATACGCGAACAGATTCC
AATCCTGCACTCCGACAGCGACTTCGACGCGATCGCGCGGCATACATCGCTACAGCTGGATACCTCACCGCGGCCGGACT
GA

Antitoxin

Protein

• Length: 68 a.a.
• Molecular weight: 7754.72 Da
• Isoelectric Point: 6.4577

>AT37668 WP_133425925.1 NZ_AP023362:c1450929-1450726 [Mycolicibacterium sp. TY81]
MTRTNIDIDDHACEVVMRRFHLTSKRDAVNFALRNLAQEALDLKAARELRGSGWDADLDELRSDRVR

Nucleotide

• Length: 204 bp

>AT37668 NZ_AP023362:c1450929-1450726 [Mycolicibacterium sp. TY81]
ATGACCCGCACAAACATCGACATCGACGACCATGCGTGCGAGGTCGTCATGCGAAGGTTCCATTTGACCAGCAAGCGAGA
CGCGGTGAACTTCGCGTTGCGCAATCTCGCCCAGGAAGCATTGGACCTCAAAGCGGCCCGAGAACTCCGCGGGTCCGGAT
GGGACGCCGATCTCGATGAATTGCGCAGCGACCGCGTCCGATGA