Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 1443120..1443781 Replicon chromosome
Accession NZ_AP023362
Organism Mycolicibacterium sp. TY81

Toxin (Protein)


Gene name vapC Uniprot ID A0A4R5W8S0
Locus tag KI240_RS06935 Protein ID WP_061001017.1
Coordinates 1443120..1443545 (-) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A4R5W7M0
Locus tag KI240_RS06940 Protein ID WP_061001016.1
Coordinates 1443542..1443781 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KI240_RS06910 (MTY81_14250) 1438779..1439672 + 894 WP_234790304.1 class A beta-lactamase -
KI240_RS06915 (MTY81_14260) 1439682..1440956 + 1275 WP_133428395.1 hypothetical protein -
KI240_RS06920 (MTY81_14270) 1441035..1441661 + 627 WP_212811945.1 dihydrofolate reductase family protein -
KI240_RS06925 (MTY81_14290) 1441979..1442263 + 285 WP_061001018.1 hypothetical protein -
KI240_RS06930 (MTY81_14300) 1442382..1442858 + 477 WP_064860476.1 DIP1984 family protein -
KI240_RS06935 (MTY81_14310) 1443120..1443545 - 426 WP_061001017.1 type II toxin-antitoxin system VapC family toxin Toxin
KI240_RS06940 (MTY81_14320) 1443542..1443781 - 240 WP_061001016.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
KI240_RS06945 (MTY81_14330) 1443883..1445337 + 1455 WP_061001015.1 DUF3375 domain-containing protein -
KI240_RS06950 (MTY81_14340) 1445334..1445945 + 612 WP_234785328.1 DUF4194 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-126)

Antitoxin

SpoVT-AbrB domain

(4-40)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 14535.33 Da        Isoelectric Point: 5.8813

>T37667 WP_061001017.1 NZ_AP023362:c1443545-1443120 [Mycolicibacterium sp. TY81]
MTSQQVTAIDTSVAVPLLVSSHPQHVAVSQWAMGRRLGLSGHALAETYSVLTRLPGDARVDPADAVALIDDNFPEPLQLG
ADTGRGAHHEFARCGVAGGATYDGLVALAAREHGAVLVTRDARAKATYDALGVNAEVLAGA

Download         Length: 426 bp

>T37667 NZ_AP023362:c1443545-1443120 [Mycolicibacterium sp. TY81]
CTGACGTCGCAGCAGGTCACGGCAATCGATACCAGCGTCGCGGTGCCCTTGCTTGTGTCCTCGCATCCGCAGCACGTCGC
GGTCTCGCAATGGGCAATGGGCCGACGTCTTGGGCTCAGCGGGCATGCGCTGGCCGAGACATACTCGGTTCTGACGCGTC
TGCCCGGCGATGCTCGTGTCGACCCTGCCGACGCGGTGGCGTTGATCGACGACAACTTCCCGGAGCCCCTTCAACTGGGT
GCCGACACGGGACGCGGTGCCCATCACGAATTCGCCCGTTGTGGCGTCGCGGGCGGCGCCACCTATGACGGCTTGGTCGC
GTTGGCCGCTCGTGAGCACGGTGCAGTCCTGGTCACTCGCGATGCCAGAGCCAAGGCAACCTACGACGCCCTCGGGGTAA
ACGCGGAAGTGCTGGCCGGCGCCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8336.60 Da        Isoelectric Point: 8.7166

>AT37667 WP_061001016.1 NZ_AP023362:c1443781-1443542 [Mycolicibacterium sp. TY81]
MEAVIDSGGRILVPKQLRDALGLTPGSTVDISAYGPGLQIVPGGRSARLVRNKDGRLVANADTVVTDEMMFALIDSGRR

Download         Length: 240 bp

>AT37667 NZ_AP023362:c1443781-1443542 [Mycolicibacterium sp. TY81]
ATGGAAGCGGTAATCGACTCGGGCGGCCGCATCTTGGTGCCCAAGCAACTCCGCGACGCGTTGGGACTGACGCCCGGTTC
GACGGTCGATATTTCGGCATATGGCCCTGGACTGCAGATTGTCCCCGGCGGCCGCTCCGCGCGCCTCGTGCGAAACAAGG
ACGGACGCCTCGTCGCCAACGCAGACACAGTCGTCACCGATGAAATGATGTTCGCGCTCATCGATTCGGGGCGACGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4R5W8S0

Antitoxin

Source ID Structure
AlphaFold DB A0A4R5W7M0

References