37665

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2789000..2789564 Replicon chromosome
Accession NZ_AP023360
Organism Catellatospora sp. IY07-71

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag CS0771_RS12625 Protein ID WP_212841141.1
Coordinates 2789000..2789347 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag CS0771_RS12630 Protein ID WP_212841142.1
Coordinates 2789334..2789564 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CS0771_RS12600 (CS0771_25030) 2784292..2785284 - 993 WP_212841137.1 RNA polymerase sigma factor SigB -
CS0771_RS12605 (CS0771_25040) 2785397..2786182 + 786 WP_212841138.1 sporulation protein -
CS0771_RS12610 (CS0771_25050) 2786320..2786742 - 423 WP_203742319.1 D-aminoacyl-tRNA deacylase -
CS0771_RS12615 (CS0771_25060) 2786836..2788296 - 1461 WP_244870754.1 methyltransferase -
CS0771_RS12620 (CS0771_25070) 2788325..2788900 + 576 WP_212841140.1 VanZ family protein -
CS0771_RS12625 (CS0771_25080) 2789000..2789347 - 348 WP_212841141.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
CS0771_RS12630 (CS0771_25090) 2789334..2789564 - 231 WP_212841142.1 ribbon-helix-helix domain-containing protein Antitoxin
CS0771_RS12635 (CS0771_25100) 2789700..2790281 + 582 WP_212841143.1 HhH-GPD-type base excision DNA repair protein -
CS0771_RS12640 (CS0771_25110) 2790285..2790749 - 465 WP_212841144.1 GNAT family N-acetyltransferase -
CS0771_RS12645 (CS0771_25120) 2791010..2792653 - 1644 WP_212841145.1 MFS transporter -
CS0771_RS12650 (CS0771_25130) 2792643..2793341 - 699 WP_212841146.1 LppX_LprAFG lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-113)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-38)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12505.26 Da        Isoelectric Point: 11.5772

>T37665 WP_212841141.1 NZ_AP023360:c2789347-2789000 [Catellatospora sp. IY07-71]
MRRGDVYLVNLDPAQGTESNKVRPAVLVGNTAANRTAERNGRGVVTVVPVTSNTERIHPFQVLIPAGEGGLARASKAQAE
QVRSVDYGRLRQRLGTLRPDTLNKLDAALRIHLNL

Download         Length: 348 bp

>T37665 NZ_AP023360:c2789347-2789000 [Catellatospora sp. IY07-71]
ATGCGGCGCGGTGACGTCTACCTGGTCAACCTCGACCCCGCTCAGGGGACCGAGTCCAACAAGGTCCGGCCGGCCGTGCT
CGTGGGCAACACCGCGGCCAACCGCACCGCCGAGCGAAACGGCCGCGGCGTCGTCACCGTCGTCCCGGTGACCTCCAACA
CCGAGCGGATCCACCCGTTCCAGGTGCTGATCCCAGCCGGCGAGGGCGGGCTGGCCCGCGCCTCGAAGGCCCAGGCAGAA
CAGGTCAGATCCGTCGACTACGGCCGCCTCCGCCAACGGCTCGGCACCCTGCGCCCCGACACGCTCAACAAACTCGACGC
CGCACTACGCATACACCTGAACCTCTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8310.04 Da        Isoelectric Point: 3.9223

>AT37665 WP_212841142.1 NZ_AP023360:c2789564-2789334 [Catellatospora sp. IY07-71]
MKLSVSLPEEDIEFIDDYADRRGTASRSAVLQRAIDLLRASELEDAYAAAYDEWEAGEDGKLWSTTAGDGLADAAR

Download         Length: 231 bp

>AT37665 NZ_AP023360:c2789564-2789334 [Catellatospora sp. IY07-71]
ATGAAACTGAGCGTCAGCCTGCCGGAGGAGGACATCGAGTTCATCGATGACTACGCCGACCGGCGTGGCACCGCCTCCCG
GTCCGCGGTCCTTCAGCGTGCCATCGACCTGCTGCGCGCCAGCGAGCTCGAAGACGCCTACGCGGCGGCCTACGACGAGT
GGGAAGCCGGCGAGGACGGAAAGCTGTGGAGCACCACCGCGGGCGACGGGCTGGCGGATGCGGCGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References